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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1911 2
1919 1
1920 1
1928 2
1937 1
1938 1
1945 1
1950 1
1953 1
1955 1
1960 1
1962 1
1963 4
1964 16
1965 4
1966 5
1967 4
1968 2
1969 11
1970 17
1971 18
1972 28
1973 20
1974 26
1975 107
1976 151
1977 150
1978 131
1979 153
1980 199
1981 264
1982 289
1983 350
1984 408
1985 448
1986 546
1987 637
1988 792
1989 894
1990 998
1991 1188
1992 1391
1993 1613
1994 1860
1995 2056
1996 2145
1997 2354
1998 2493
1999 2811
2000 2909
2001 3163
2002 3287
2003 3691
2004 4027
2005 4495
2006 4717
2007 5082
2008 5422
2009 6212
2010 7130
2011 8123
2012 8914
2013 9788
2014 11216
2015 12149
2016 10504
2017 10414
2018 12713
2019 13660
2020 15632
2021 18258
2022 17206
2023 16655
2024 6803
2025 1

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218,181 results

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Quoted phrase not found in phrase index: "Phases of clinical research"
Page 1
Pathophysiology of coronary artery disease.
Libby P, Theroux P. Libby P, et al. Circulation. 2005 Jun 28;111(25):3481-8. doi: 10.1161/CIRCULATIONAHA.105.537878. Circulation. 2005. PMID: 15983262 Review.
We review here how these advances have altered our concepts of and clinical approaches to both the chronic and acute phases of CAD. Previously considered a cholesterol storage disease, we currently view atherosclerosis as an inflammatory disorder. ...Alterations in …
We review here how these advances have altered our concepts of and clinical approaches to both the chronic and acute phases of …
Key cost drivers of pharmaceutical clinical trials in the United States.
Sertkaya A, Wong HH, Jessup A, Beleche T. Sertkaya A, et al. Clin Trials. 2016 Apr;13(2):117-26. doi: 10.1177/1740774515625964. Epub 2016 Feb 8. Clin Trials. 2016. PMID: 26908540
BACKGROUND: The increasing cost of clinical research has significant implications for public health, as it affects drug companies' willingness to undertake clinical trials, which in turn limits patient access to novel treatments. Thus, gaining a better unders …
BACKGROUND: The increasing cost of clinical research has significant implications for public health, as it affects drug compan …
Targeting CD47 for cancer immunotherapy.
Jiang Z, Sun H, Yu J, Tian W, Song Y. Jiang Z, et al. J Hematol Oncol. 2021 Oct 30;14(1):180. doi: 10.1186/s13045-021-01197-w. J Hematol Oncol. 2021. PMID: 34717705 Free PMC article. Review.
Much progress has been made in targeting CD47 for cancer immunotherapy in solid tumors (ST) and hematological malignancies. We summarized the CD47-related clinical research and analyzed the research trend both in the USA and in China. ...The ST include gastri …
Much progress has been made in targeting CD47 for cancer immunotherapy in solid tumors (ST) and hematological malignancies. We summarized th …
Ovarian hormones and obesity.
Leeners B, Geary N, Tobler PN, Asarian L. Leeners B, et al. Hum Reprod Update. 2017 May 1;23(3):300-321. doi: 10.1093/humupd/dmw045. Hum Reprod Update. 2017. PMID: 28333235 Free PMC article. Review.
Severe obesity is more prevalent in women than men worldwide, and obesity pathophysiology and the resultant obesity-related disease risks differ in women and men. The underlying mechanisms are largely unknown. Pre-clinical and clinical research indicate that …
Severe obesity is more prevalent in women than men worldwide, and obesity pathophysiology and the resultant obesity-related disease risks di …
Evaluating artificial intelligence in medicine: phases of clinical research.
Park Y, Jackson GP, Foreman MA, Gruen D, Hu J, Das AK. Park Y, et al. JAMIA Open. 2020 Sep 8;3(3):326-331. doi: 10.1093/jamiaopen/ooaa033. eCollection 2020 Oct. JAMIA Open. 2020. PMID: 33215066 Free PMC article.
The complexity of healthcare, compounded by the user- and context-dependent nature of AI applications, calls for a multifaceted approach beyond traditional in silico evaluation of AI. We propose an interdisciplinary, phased research framework for evaluation of AI implement …
The complexity of healthcare, compounded by the user- and context-dependent nature of AI applications, calls for a multifaceted approach bey …
Novel strategies for cancer immunotherapy: counter-immunoediting therapy.
Liu S, Sun Q, Ren X. Liu S, et al. J Hematol Oncol. 2023 Apr 13;16(1):38. doi: 10.1186/s13045-023-01430-8. J Hematol Oncol. 2023. PMID: 37055849 Free PMC article. Review.
The process of cancer immunoediting refers to the cooperative interaction between tumor cells and the immune system that involves three phases: elimination, equilibrium, and escape. During these phases, conflicting interactions between the immune system and tumor ce …
The process of cancer immunoediting refers to the cooperative interaction between tumor cells and the immune system that involves three p …
Status of clinical research in neurology in Germany-A national survey.
Lohmann L, Lammerskitten A, Korsen M, Dodel R, Gaul C, Hamer HM, Kleineberg NN, Ludolph AC, Mayer G, Poli S, Saur D, Steinhoff BJ, Timmermann L, Klotz L, Meuth SG. Lohmann L, et al. Eur J Neurol. 2021 May;28(5):1446-1452. doi: 10.1111/ene.14763. Epub 2021 Feb 26. Eur J Neurol. 2021. PMID: 33539600
BACKGROUND AND PURPOSE: To provide an overview on the status of clinical research in neurology in Germany. METHODS: German university hospitals, nonuniversity hospitals, and neurological medical practices were surveyed regarding their clinical research …
BACKGROUND AND PURPOSE: To provide an overview on the status of clinical research in neurology in Germany. METHODS: German uni …
Clinical research in the treatment of tuberculosis: current status and future prospects.
Chang KC, Yew WW, Sotgiu G. Chang KC, et al. Int J Tuberc Lung Dis. 2015 Dec;19(12):1417-27. doi: 10.5588/ijtld.15.0216. Int J Tuberc Lung Dis. 2015. PMID: 26614181 Review.
To supplement previous state-of-art reviews on anti-tuberculosis treatment and to pave the way forward with reference to the current status, we systematically reviewed published literature on clinical research on tuberculosis (TB) over the past decade in the treatme …
To supplement previous state-of-art reviews on anti-tuberculosis treatment and to pave the way forward with reference to the current status, …
Proposed clinical phases for the improvement of personalized treatment of checkpoint inhibitor-related pneumonitis.
Zhou C, Yang Y, Lin X, Fang N, Chen L, Jiang J, Deng H, Deng Y, Wan M, Qiu G, Sun N, Wu D, Long X, Zhong C, Xie X, Xie Z, Liu M, Ouyang M, Qin Y, Petrella F, Fiorelli A, Bravaccini S, Kataoka Y, Watanabe S, Goto T, Solli P, Igai H, Saito Y, Tsoukalas N, Nakada T, Li S, Chen R. Zhou C, et al. Front Immunol. 2022 Jul 20;13:935779. doi: 10.3389/fimmu.2022.935779. eCollection 2022. Front Immunol. 2022. PMID: 35967342 Free PMC article.
After a comprehensive analysis, we proposed acute, subacute, and chronic phases of CIP and summarized each phase's characteristics. RESULTS: There were 51 patients in the acute phase, 22 in the subacute phase, and 11 in the chronic phase. …
After a comprehensive analysis, we proposed acute, subacute, and chronic phases of CIP and summarized each phase's char …
[Application of MIDD in Clinical Research of Antitumor Drugs].
Yu M, Wang H. Yu M, et al. Zhongguo Fei Ai Za Zhi. 2022 Jul 20;25(7):487-492. doi: 10.3779/j.issn.1009-3419.2022.101.38. Zhongguo Fei Ai Za Zhi. 2022. PMID: 35899446 Free PMC article. Chinese.
The antitumor drug has become one of the focused areas in new drug research and development. Their clinical research generally consumes a long period of time, with high cost and high risk. Model-informed drug development (MIDD) integrates and quantitatively a …
The antitumor drug has become one of the focused areas in new drug research and development. Their clinical research ge …
218,181 results
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