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Year Number of Results
1976 1
1982 1
1984 1
1986 3
1987 1
1989 2
1991 1
1992 2
1993 3
1994 3
1995 2
1996 1
1997 7
1998 8
1999 2
2000 3
2001 8
2002 8
2003 9
2004 6
2005 2
2006 6
2007 4
2008 15
2009 22
2010 19
2011 19
2012 18
2013 23
2014 24
2015 19
2016 23
2017 20
2018 30
2019 24
2020 29
2021 14
2022 19
2023 12
2024 6

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361 results

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Page 1
Pilocytic Astrocytoma: A Review of General, Clinical, and Molecular Characteristics.
Salles D, Laviola G, Malinverni ACM, Stávale JN. Salles D, et al. J Child Neurol. 2020 Oct;35(12):852-858. doi: 10.1177/0883073820937225. Epub 2020 Jul 20. J Child Neurol. 2020. PMID: 32691644 Review.
The present study aimed to list the main characteristics about this tumor, to better understand the diagnosis and treatment of these patients, and was conducted on search of the published studies available in NCBI, PubMed, MEDLINE, Scielo, and Google Scholar. It was possible to d …
The present study aimed to list the main characteristics about this tumor, to better understand the diagnosis and treatment of these patient …
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.
Jones DT, Hutter B, Jäger N, Korshunov A, Kool M, Warnatz HJ, Zichner T, Lambert SR, Ryzhova M, Quang DA, Fontebasso AM, Stütz AM, Hutter S, Zuckermann M, Sturm D, Gronych J, Lasitschka B, Schmidt S, Seker-Cin H, Witt H, Sultan M, Ralser M, Northcott PA, Hovestadt V, Bender S, Pfaff E, Stark S, Faury D, Schwartzentruber J, Majewski J, Weber UD, Zapatka M, Raeder B, Schlesner M, Worth CL, Bartholomae CC, von Kalle C, Imbusch CD, Radomski S, Lawerenz C, van Sluis P, Koster J, Volckmann R, Versteeg R, Lehrach H, Monoranu C, Winkler B, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, Ebinger M, Schuhmann MU, Cho YJ, Pomeroy SL, von Deimling A, Witt O, Taylor MD, Wolf S, Karajannis MA, Eberhart CG, Scheurlen W, Hasselblatt M, Ligon KL, Kieran MW, Korbel JO, Yaspo ML, Brors B, Felsberg J, Reifenberger G, Collins VP, Jabado N, Eils R, Lichter P, Pfister SM; International Cancer Genome Consortium PedBrain Tumor Project. Jones DT, et al. Nat Genet. 2013 Aug;45(8):927-32. doi: 10.1038/ng.2682. Epub 2013 Jun 30. Nat Genet. 2013. PMID: 23817572 Free PMC article.
Pilocytic astrocytoma, the most common childhood brain tumor, is typically associated with mitogen-activated protein kinase (MAPK) pathway alterations. ...Our findings thus identify new potential therapeutic targets in distinct subsets of pilocytic astrocy …
Pilocytic astrocytoma, the most common childhood brain tumor, is typically associated with mitogen-activated protein kinase (M …
Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M. Fangusaro J, et al. Lancet Oncol. 2019 Jul;20(7):1011-1022. doi: 10.1016/S1470-2045(19)30277-3. Epub 2019 May 28. Lancet Oncol. 2019. PMID: 31151904 Free PMC article. Clinical Trial.
Patients were assigned to six unique strata according to histology, tumour location, NF1 status, and BRAF aberration status; herein, we report the results of strata 1 and 3. Stratum 1 comprised patients with WHO grade I pilocytic astrocytoma harbouring either one of …
Patients were assigned to six unique strata according to histology, tumour location, NF1 status, and BRAF aberration status; herein, we repo …
The distribution of BRAF gene fusions in solid tumors and response to targeted therapy.
Ross JS, Wang K, Chmielecki J, Gay L, Johnson A, Chudnovsky J, Yelensky R, Lipson D, Ali SM, Elvin JA, Vergilio JA, Roels S, Miller VA, Nakamura BN, Gray A, Wong MK, Stephens PJ. Ross JS, et al. Int J Cancer. 2016 Feb 15;138(4):881-90. doi: 10.1002/ijc.29825. Epub 2015 Sep 8. Int J Cancer. 2016. PMID: 26314551 Free PMC article.
BRAF fusions involving the intact in-frame BRAF kinase domain were observed in 55 (0.3%) of 20,573 tumors, across 12 distinct tumor types, including 20 novel BRAF fusions. ...
BRAF fusions involving the intact in-frame BRAF kinase domain were observed in 55 (0.3%) of 20,573 tumors, across 12 distinct tumor t …
Evidence-Based Practice: Temozolomide Beyond Glioblastoma.
Chua J, Nafziger E, Leung D. Chua J, et al. Curr Oncol Rep. 2019 Mar 5;21(4):30. doi: 10.1007/s11912-019-0783-5. Curr Oncol Rep. 2019. PMID: 30835007 Review.
In this review, we will examine the use of temozolomide in other contexts for treating gliomas, including recurrent glioblastoma, glioblastoma in the elderly, diffuse low- and high-grade gliomas, non-diffuse gliomas, diffuse intrinsic pontine glioma (DIPG), ependymoma, pilocyt …
In this review, we will examine the use of temozolomide in other contexts for treating gliomas, including recurrent glioblastoma, glioblasto …
Low-grade gliomas.
Stieber VW. Stieber VW. Curr Treat Options Oncol. 2001 Dec;2(6):495-506. doi: 10.1007/s11864-001-0071-z. Curr Treat Options Oncol. 2001. PMID: 12057095 Review.
The most common variants are pilocytic and low-grade astrocytomas, oligodendrogliomas, and mixed oligo-astrocytomas located in the cerebral hemispheres. Prognostic factors that predict progression-free and overall survival include young age, pilocytic histology, good Karno …
The most common variants are pilocytic and low-grade astrocytomas, oligodendrogliomas, and mixed oligo-astrocytomas located in the cerebral …
Posterior fossa tumors in children: current insights.
Formentin C, Joaquim AF, Ghizoni E. Formentin C, et al. Eur J Pediatr. 2023 Nov;182(11):4833-4850. doi: 10.1007/s00431-023-05189-5. Epub 2023 Sep 8. Eur J Pediatr. 2023. PMID: 37679511 Review.
Molecular biomarkers play an important role in the diagnosis, prognosis, and treatment of childhood posterior fossa tumors and can be used to predict patient outcomes and response to treatment and monitor its effectiveness. ...
Molecular biomarkers play an important role in the diagnosis, prognosis, and treatment of childhood posterior fossa tumors and can be used t …
Molecular genetics of gliomas.
Appin CL, Brat DJ. Appin CL, et al. Cancer J. 2014 Jan-Feb;20(1):66-72. doi: 10.1097/PPO.0000000000000020. Cancer J. 2014. PMID: 24445767 Review.
Histologic classification is increasingly aided by molecular genetic studies, which assist in the diagnosis and provide prognostic and predictive value. Mutations in IDH1 are frequent in grades II and III astrocytomas, oligodendrogliomas, and oligoastrocytomas, as well as …
Histologic classification is increasingly aided by molecular genetic studies, which assist in the diagnosis and provide prognostic and pr …
Pediatric gliomas.
Pfister S, Witt O. Pfister S, et al. Recent Results Cancer Res. 2009;171:67-81. doi: 10.1007/978-3-540-31206-2_4. Recent Results Cancer Res. 2009. PMID: 19322538 Review.
In addition, these tumors are largely different from their counterparts occurring in adults, although they are histologically indistinguishable and uniformly classified by the current WHO classification for CNS tumors. Pilocytic astrocytoma (WHO grade I), mainly ari …
In addition, these tumors are largely different from their counterparts occurring in adults, although they are histologically indistinguisha …
Pilocytic astrocytoma in adults: Histopathological, immunohistochemical and molecular study with clinical association.
Salles D, Santino SF, Diana P, Malinverni ACM, Stávale JN. Salles D, et al. Pathol Res Pract. 2023 Dec;252:154942. doi: 10.1016/j.prp.2023.154942. Epub 2023 Nov 14. Pathol Res Pract. 2023. PMID: 37984046
Pilocytic astrocytoma is the most common primary CNS neoplasm in children and adolescents, rare after the first two decades of life. While some authors report a favorable prognosis in the adult age group with the tumor, others have associated it with higher mortalit …
Pilocytic astrocytoma is the most common primary CNS neoplasm in children and adolescents, rare after the first two decades of …
361 results