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Year Number of Results
1996 2
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2005 5
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84 results

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Quoted phrase not found in phrase index: "Polysomy 10"
Page 1
Genetic alterations and protein expression of HER2 and chromosome 17 polysomy in breast cancer.
Zhu X, Lu Y, Lu H, Yang W, Tu X, Cai X, Zhou X. Zhu X, et al. Hum Pathol. 2011 Oct;42(10):1499-504. doi: 10.1016/j.humpath.2010.04.023. Epub 2011 Jun 14. Hum Pathol. 2011. PMID: 21676436
Fluorescence in situ hybridization showed that 57.4% of cases exhibited HER2 amplification but 41.4% did not, and 1.2% exhibited an equivocal status. Immunohistochemistry showed that 10.4%, 16.8%, 38.3%, and 34.5% of cases had scores of 0, 1+, 2+, and 3+, respectively. ... …
Fluorescence in situ hybridization showed that 57.4% of cases exhibited HER2 amplification but 41.4% did not, and 1.2% exhibited an equivoca …
Breast cancer biomarkers and HER2 testing after 10 years of anti-HER2 therapy.
Ross JS. Ross JS. Drug News Perspect. 2009 Mar;22(2):93-106. doi: 10.1358/dnp.2009.22.2.1334452. Drug News Perspect. 2009. PMID: 19330168 Free article. Review.
A series of quality assurance recommendations for the marketed slide-based HER2 testing approaches including immunohistochemistry (IHC), fluorescence in situ hybridization (FISH) and chromogenic in situ hybridization (CISH/SISH) has recently been published by the American Society …
A series of quality assurance recommendations for the marketed slide-based HER2 testing approaches including immunohistochemistry (IHC), flu …
Evaluating the Significance of Pancreatobiliary Fluorescence In Situ Hybridization Polysomy on Prognosis in De Novo Cholangiocarcinoma.
Ji H, Barr Fritcher EG, Yin J, Bainter TM, Zemla TJ, Gores GJ, Halling KC, Kipp BR, Roberts LR. Ji H, et al. Clin Transl Gastroenterol. 2022 Oct 1;13(10):e00523. doi: 10.14309/ctg.0000000000000523. Clin Transl Gastroenterol. 2022. PMID: 36000989 Free PMC article.
For de novo CCA, both polysomy and nonpolysomy were associated with worse OS compared with disomy (polysomy: hazard ratio [HR] = 2.09, 95% confidence interval [CI] = 1.14-3.83; nonpolysomy: HR = 2.4, 95% CI = 0.54-2.46; P = 0.027). For PSC CCA, neither polysomy …
For de novo CCA, both polysomy and nonpolysomy were associated with worse OS compared with disomy (polysomy: hazard ratio [HR] …
The clinical and prognostic role of ALK in glioblastoma.
Franceschi E, De Biase D, Di Nunno V, Pession A, Tosoni A, Gatto L, Tallini G, Visani M, Lodi R, Bartolini S, Brandes AA. Franceschi E, et al. Pathol Res Pract. 2021 May;221:153447. doi: 10.1016/j.prp.2021.153447. Epub 2021 Apr 15. Pathol Res Pract. 2021. PMID: 33887544
Assuming an ALK overexpression in 20 % of patients we planned a sample of 44 patients to achieve a probability of 90 % to include from 10 % to 30 % of patients with ALK alterations. RESULTS: We evaluated 44 patients with IDH wt GBM, treated in our institution and dead due …
Assuming an ALK overexpression in 20 % of patients we planned a sample of 44 patients to achieve a probability of 90 % to include from 10 …
Clinical, radiological and genomic features and targeted therapy in BRAF V600E mutant adult glioblastoma.
Lim-Fat MJ, Song KW, Iorgulescu JB, Andersen BM, Forst DA, Jordan JT, Gerstner ER, Reardon DA, Wen PY, Arrillaga-Romany I. Lim-Fat MJ, et al. J Neurooncol. 2021 May;152(3):515-522. doi: 10.1007/s11060-021-03719-5. Epub 2021 Mar 1. J Neurooncol. 2021. PMID: 33646525 Free PMC article.
RESULTS: Nineteen glioblastoma patients were included, with median age at diagnosis of 41-years-old (range 22-69). Only 1/18 was IDH1/2-mutant; 10/17 had MGMT unmethylated tumors. The most common additional molecular alterations were CDKN2A/2B biallelic loss/loss-of-functi …
RESULTS: Nineteen glioblastoma patients were included, with median age at diagnosis of 41-years-old (range 22-69). Only 1/18 was IDH1/2-muta …
MYC and human telomerase gene (TERC) copy number gain in early-stage non-small cell lung cancer.
Flacco A, Ludovini V, Bianconi F, Ragusa M, Bellezza G, Tofanetti FR, Pistola L, Siggillino A, Vannucci J, Cagini L, Sidoni A, Puma F, Varella-Garcia M, Crinò L. Flacco A, et al. Am J Clin Oncol. 2015 Apr;38(2):152-8. doi: 10.1097/COC.0000000000000012. Am J Clin Oncol. 2015. PMID: 25806711 Free PMC article.
MYC and TERC concurrent FISH-positive was observed in 12 cases (11%): 2 (17%) cases with gene amplification and 10 (83%) with high polysomy. By using the ROC analysis, high MYC (mean 2.83 copies/cell) and TERC (mean 2.65 copies/cell) GCNs were observed in 60 (53.1%) …
MYC and TERC concurrent FISH-positive was observed in 12 cases (11%): 2 (17%) cases with gene amplification and 10 (83%) with high …
Erlotinib efficacy in NSCLC patients with high polysomy of chromosome 7 and EGFR/KRas wild-type tumors.
Toffalorio F, de Marinis F, Conforti F, Spitaleri G, Catania C, Noberasco C, Lazzari C, Vecchio F, Stufano V, Barberis M, De Pas T. Toffalorio F, et al. J Thorac Oncol. 2015 Feb;10(2):392-6. doi: 10.1097/JTO.0000000000000355. J Thorac Oncol. 2015. PMID: 25611230 Free article.
EGFR wild-type patients represent a large and heterogeneous group of patients. In this setting, the role played by high polysomy of chromosome 7 still remains controversial. Indeed, previous reports did not discriminate between chromosome 7 high polysomy and EGFR am …
EGFR wild-type patients represent a large and heterogeneous group of patients. In this setting, the role played by high polysomy of c …
The influence of polysomy 17 on HER2 gene and protein expression in adenocarcinoma of the breast: a fluorescent in situ hybridization, immunohistochemical, and isotopic mRNA in situ hybridization study.
Downs-Kelly E, Yoder BJ, Stoler M, Tubbs RR, Skacel M, Grogan T, Roche P, Hicks DG. Downs-Kelly E, et al. Am J Surg Pathol. 2005 Sep;29(9):1221-7. doi: 10.1097/01.pas.0000165528.78945.95. Am J Surg Pathol. 2005. PMID: 16096413
Breast carcinomas with amplification of HER2 on chromosome 17 are associated with HER2 protein overexpression, adversely affecting prognosis and predicting response to Herceptin therapy. Chromosome 17 polysomy is encountered in assessing HER2 gene status, and its impact on …
Breast carcinomas with amplification of HER2 on chromosome 17 are associated with HER2 protein overexpression, adversely affecting prognosis …
Cytogenetics and prognosis for uveal melanoma in Korean patients.
Lee CS, Lee J, Choi JJ, Yang WI, Yoon JS, Lee SY, Lee SC. Lee CS, et al. Acta Ophthalmol. 2011 Jun;89(4):e310-4. doi: 10.1111/j.1755-3768.2010.02099.x. Epub 2011 Feb 11. Acta Ophthalmol. 2011. PMID: 21310015 Free article.

Of the 20 tissue blocks with available cytogenetic data, there was monosomy 3 in seven (35%) and polysomy 8 in four (20%). The presence of monosomy 3 (p < 0.001), polysomy 8 (p < 0.001), ciliary body involvement (p < 0.001), a mitotic rate 5/40 high-power f

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Of the 20 tissue blocks with available cytogenetic data, there was monosomy 3 in seven (35%) and polysomy 8 in four (20%). The presen …
The gene copy number of c-MET has a significant impact on progression-free survival in Korean patients with ovarian carcinoma.
Kim WY, Shim SH, Jung HY, Dong M, Kim SN, Lee SJ. Kim WY, et al. Hum Pathol. 2017 Jun;64:98-105. doi: 10.1016/j.humpath.2017.04.002. Epub 2017 Apr 17. Hum Pathol. 2017. PMID: 28428108
MET protein expression and GCN status were determined using immunohistochemistry (IHC) and silver in situ hybridization, respectively, in 105 ovarian carcinomas comprising 63 serous, 12 mucinous, 20 clear cell, and 10 endometrioid carcinomas. All cases had been treated and …
MET protein expression and GCN status were determined using immunohistochemistry (IHC) and silver in situ hybridization, respectively, in 10 …
84 results