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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 2
1978 4
1979 2
1980 2
1981 5
1982 2
1983 3
1984 2
1986 1
1987 2
1990 2
1991 1
1992 2
1993 4
1994 2
1995 4
1996 2
1998 6
1999 23
2000 67
2001 81
2002 79
2003 77
2004 80
2005 69
2006 84
2007 70
2008 81
2009 76
2010 60
2011 51
2012 58
2013 64
2014 55
2015 44
2016 38
2017 29
2018 23
2019 18
2020 0
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1,165 results
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Page 1
Brief and prolonged effects of Lissauer tract stimulation on dorsal horn cells.
Wall PD, et al. Pain 1999. PMID 10568867
Increased excitability of dorsal horn neurones may play a critical role in producing some pain states and there is evidence that the excitability of neurones lying throughout the dorsal horn is subject to regulation by cells in its most superficial laminae. ...Generally, this was accompanied by no excitation of deeper dorsal horn cells but commonly by a period of inhibition, often followed by facilitation. ...
Increased excitability of dorsal horn neurones may play a critical role in producing some pain states and there is evidence that the …
Enhancing KCC2 function counteracts morphine-induced hyperalgesia
Ferrini F, et al. Sci Rep 2017. PMID 28634406 Free PMC article.
Previous reports associated MIH with a decreased expression of the Cl(-) extruder KCC2 in the superficial dorsal horn (SDH) of the spinal cord, weakening spinal GABA(A)/glycine-mediated postsynaptic inhibition. Here, we tested whether the administration of small molecules enhancing KCC2, CLP257 and its pro-drug CLP290, may counteract MIH. ...
Previous reports associated MIH with a decreased expression of the Cl(-) extruder KCC2 in the superficial dorsal horn (SDH) of the sp …
Implication of Kv7 Channels in the Spinal Antinociceptive Actions of Celecoxib
Vicente-Baz J, et al. J Pharmacol Exp Ther 2019. PMID 31235533
Electrophysiological recordings of ventral roots and dorsal horn neurones were obtained, and the effects of celecoxib and K(v)7 modulators on responses to repetitive dorsal root stimulation at C-fiber intensity were assessed. Celecoxib applied at clinically relevant concentrations produced depressant effects on responses to dorsal root stimulation recorded from both ventral roots and individual dorsal horn neurones; by contrast, the non-nociceptive monosynaptic reflex was unaffected. ...
Electrophysiological recordings of ventral roots and dorsal horn neurones were obtained, and the effects of celecoxib and K(v) …
Pharmacological rescue of nociceptive hypersensitivity and oxytocin analgesia impairment in a rat model of neonatal maternal separation
Melchior M, et al. Pain 2018. PMID 30169420
Oxytocin (OT), known for its neurohormonal effects around birth, has recently been suggested for being a critical determinant in neurodevelopmental disorders. ...
Oxytocin (OT), known for its neurohormonal effects around birth, has recently been suggested for being a critical determinant in neur …
Regulation of Nociceptive Glutamatergic Signaling by Presynaptic Kv3.4 Channels in the Rat Spinal Dorsal Horn.
Muqeem T, et al. J Neurosci 2018. PMID 29540546 Free PMC article.
Presynaptic voltage-gated K(+) (Kv) channels in dorsal root ganglion (DRG) neurons are thought to regulate nociceptive synaptic transmission in the spinal dorsal horn. ...Here, we show that Kv3.4 channels have a significant impact on glutamatergic synaptic transmission in the dorsal horn, further illuminating its potential as a molecular pain therapeutic target....
Presynaptic voltage-gated K(+) (Kv) channels in dorsal root ganglion (DRG) neurons are thought to regulate nociceptive synaptic transmission …
Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain
Bannister K, et al. Pain 2017. PMID 28832395 Free PMC article.
Spinal GBP also significantly inhibited dorsal horn wide-dynamic-range neuronal responses to a range of evoked stimuli in SNL rats. By contrast, GBP microinjected bilaterally into the rostral anterior cingulate cortex (rACC), produced CPP, and elicited NAc DA release selectively in SNL rats but did not reverse tactile allodynia and had marginal effects on wide-dynamic-range neuronal activity. ...
Spinal GBP also significantly inhibited dorsal horn wide-dynamic-range neuronal responses to a range of evoked stimuli in SNL rats. B …
Characterization and pharmacological modulation of noci-responsive deep dorsal horn neurons across diverse rat models of pathological pain.
McGaraughty S, et al. J Neurophysiol 2018. PMID 30067136 Free article.
The diversity of incoming/modulating inputs to the deep dorsal horn positions this group of neurons as an important intersection within the pain system to validate novel therapeutics. ...Effects of diverse pharmacology on these neurons is also summarized from published and unpublished data all recorded under the same conditions to facilitate comparison. ...
The diversity of incoming/modulating inputs to the deep dorsal horn positions this group of neurons as an important intersection with …
Metformin attenuates increase of synaptic number in the rat spinal dorsal horn with painful diabetic neuropathy induced by type 2 diabetes: a stereological study.
Lin JY, et al. Neurochem Res 2018. PMID 30306321
Parameters of the whole length of spinal dorsal horn showed no significant changes (P > 0.05). Our results suggest that high fat diet/low dose streptozotocin diabetes related PDN is also associated with a numerical increase of synapses in the L5 segment of spinal dorsal horn but not in the whole length of spinal dorsal horn. Furthermore, the analgesic effect of metformin against PDN is related to its inhibition of numerical increase of synaptic number in the rat spinal dorsal horn....
Parameters of the whole length of spinal dorsal horn showed no significant changes (P > 0.05). Our results suggest that high fat d …
Mechanosensitive ion channels in articular nociceptors drive mechanical allodynia in osteoarthritis
He BH, et al. Osteoarthritis Cartilage 2017. PMID 28882752 Free article.
Dorsal horn neuronal activation was assessed by Fos immunoreactivity. RESULTS: In examining the gating properties of MSICs of naïve and OA mice, we discovered that their activation threshold is greatly reduced, causing their opening at significantly lower stimuli intensities. ...These channels are reversibly inhibited by the selective MSIC inhibitor GsMTx4, and the intra-articular injection of this peptide significantly reduced the activation of dorsal horn nociceptive circuits and primary mechanical allodynia in OA mice. ...
Dorsal horn neuronal activation was assessed by Fos immunoreactivity. RESULTS: In examining the gating properties of MSICs of naïve a …
Dendritic spine dysgenesis in superficial dorsal horn sensory neurons after spinal cord injury.
Cao XC, et al. Mol Pain 2017. PMID 28326929 Free PMC article.
To extend these findings, we performed a follow-up structural analysis to assess whether dendritic spine remodeling occurs on superficial dorsal horn neurons located in lamina II after spinal cord injury. ...
To extend these findings, we performed a follow-up structural analysis to assess whether dendritic spine remodeling occurs on superficial do …
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