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112 results

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Quoted phrase not found in phrase index: "Primary release disorder of platelets"
Page 1
Cancer-associated venous thromboembolism: Burden, mechanisms, and management.
Ay C, Pabinger I, Cohen AT. Ay C, et al. Thromb Haemost. 2017 Jan 26;117(2):219-230. doi: 10.1160/TH16-08-0615. Epub 2016 Nov 24. Thromb Haemost. 2017. PMID: 27882374 Review.
In this review, we discuss the epidemiology and burden of the disease, the pathophysiology of cancer-associated VTE, and the clinical treatment options for both primary prevention and acute treatment. ...Furthermore, blood count parameters (e.g. platelets …
In this review, we discuss the epidemiology and burden of the disease, the pathophysiology of cancer-associated VTE, and the clinical …
Platelets in the NETworks interweaving inflammation and thrombosis.
Wienkamp AK, Erpenbeck L, Rossaint J. Wienkamp AK, et al. Front Immunol. 2022 Aug 1;13:953129. doi: 10.3389/fimmu.2022.953129. eCollection 2022. Front Immunol. 2022. PMID: 35979369 Free PMC article. Review.
Platelets are well characterized for their indispensable role in primary hemostasis to control hemorrhage. ...In this review, we will discuss the interplay between platelets and NETs and the potential of this alliance to influence the course of inflamm …
Platelets are well characterized for their indispensable role in primary hemostasis to control hemorrhage. ...In this review, …
Vascular endothelium - Gatekeeper of vessel health.
Cahill PA, Redmond EM. Cahill PA, et al. Atherosclerosis. 2016 May;248:97-109. doi: 10.1016/j.atherosclerosis.2016.03.007. Epub 2016 Mar 9. Atherosclerosis. 2016. PMID: 26994427 Free PMC article. Review.
The vascular endothelium is an interface between the blood stream and the vessel wall. Changes in this single cell layer of the artery wall are believed of primary importance in the pathogenesis of vascular disease/atherosclerosis. ...Compromised endothelial …
The vascular endothelium is an interface between the blood stream and the vessel wall. Changes in this single cell layer of the arter …
The Pathophysiology and Management of Acute Traumatic Coagulopathy.
Duan K, Yu W, Li N. Duan K, et al. Clin Appl Thromb Hemost. 2015 Oct;21(7):645-52. doi: 10.1177/1076029613516190. Epub 2013 Dec 19. Clin Appl Thromb Hemost. 2015. PMID: 24363215 Free article. Review.
To date, the possible mechanisms include activation of protein C, shedding of endothelial glycocalyx, catecholamine release, platelet dysfunction, primary, and secondary fibrinolysis, with tissue injury and hypoperfusion as the triggers. Classic factors such …
To date, the possible mechanisms include activation of protein C, shedding of endothelial glycocalyx, catecholamine release, plate …
How can platelet proteomics best be used to interrogate disease?
Zellner M. Zellner M. Platelets. 2023 Dec;34(1):2220046. doi: 10.1080/09537104.2023.2220046. Platelets. 2023. PMID: 37272536 Free article.
Hence, recording these dynamic protein changes under physiological and pathophysiological conditions is paramount in platelet proteomics. To effectively study diseases through platelet proteomics, it is crucial to consider platelets' primary regulatory …
Hence, recording these dynamic protein changes under physiological and pathophysiological conditions is paramount in platelet proteom …
Statins for acute ischemic stroke.
Squizzato A, Romualdi E, Dentali F, Ageno W. Squizzato A, et al. Cochrane Database Syst Rev. 2011 Aug 10;(8):CD007551. doi: 10.1002/14651858.CD007551.pub2. Cochrane Database Syst Rev. 2011. PMID: 21833959 Review.
We based quantitative analysis of outcome on the intention-to-treat principle. The primary outcomes were mortality from ischemic stroke and mortality from adverse drug effects, bleedings and infections. ...No cases of rhabdomyolysis (the breakdown of muscle fibres resultin …
We based quantitative analysis of outcome on the intention-to-treat principle. The primary outcomes were mortality from ischemic stro …
Myelofibrosis with myeloid metaplasia.
Barosi G. Barosi G. Hematol Oncol Clin North Am. 2003 Oct;17(5):1211-26. doi: 10.1016/s0889-8588(03)00080-7. Hematol Oncol Clin North Am. 2003. PMID: 14560783 Review.
MMM is a chronic myeloproliferative disorder characterized by bone marrow fibrosis and neoangiogenesis, constitutive release ofa high number of CD34+ stem cells from the bone marrow, and extramedullary hematopoiesis. ...Animal models suggest that chronic exposure to …
MMM is a chronic myeloproliferative disorder characterized by bone marrow fibrosis and neoangiogenesis, constitutive release o …
Changes in the Proteome of Platelets from Patients with Critical Progression of COVID-19.
Wolny M, Rozanova S, Knabbe C, Pfeiffer K, Barkovits K, Marcus K, Birschmann I. Wolny M, et al. Cells. 2023 Sep 1;12(17):2191. doi: 10.3390/cells12172191. Cells. 2023. PMID: 37681923 Free PMC article.
Platelets, the smallest cells in human blood, known for their role in primary hemostasis, are also able to interact with pathogens and play a crucial role in the immune response. ...This study aims to further elucidate the role of platelets in COVID-19 …
Platelets, the smallest cells in human blood, known for their role in primary hemostasis, are also able to interact wit …
Proteomics and enriched biological processes in Antiphospholipid syndrome: A systematic review.
Anunciación-Llunell A, Miró-Mur F, Esteve-Valverde E, Marques-Soares J, Pardos-Gea J, Alijotas-Reig J. Anunciación-Llunell A, et al. Autoimmun Rev. 2021 Dec;20(12):102982. doi: 10.1016/j.autrev.2021.102982. Epub 2021 Oct 27. Autoimmun Rev. 2021. PMID: 34718168 Review.
Advances in technologies of mass spectrometry brings improvements in proteomics and results in assessment of soluble or cellular proteins which could be candidates for clinical biomarkers of primary APS. The use of blood as a source of proteins ease the acquisition …
Advances in technologies of mass spectrometry brings improvements in proteomics and results in assessment of soluble or cellular proteins wh …
A phase I oncolytic virus trial with vesicular stomatitis virus expressing human interferon beta and tyrosinase related protein 1 administered intratumorally and intravenously in uveal melanoma: safety, efficacy, and T cell responses.
Smith KER, Peng KW, Pulido JS, Weisbrod AJ, Strand CA, Allred JB, Newsom AN, Zhang L, Packiriswamy N, Kottke T, Tonne JM, Moore M, Montane HN, Kottschade LA, McWilliams RR, Dudek AZ, Yan Y, Dimou A, Markovic SN, Federspiel MJ, Vile RG, Dronca RS, Block MS. Smith KER, et al. Front Immunol. 2023 Oct 31;14:1279387. doi: 10.3389/fimmu.2023.1279387. eCollection 2023. Front Immunol. 2023. PMID: 38022659 Free PMC article. Clinical Trial.
INTRODUCTION: Metastatic uveal melanoma (MUM) has a poor prognosis and treatment options are limited. These patients do not typically experience durable responses to immune checkpoint inhibitors (ICIs). ...Median follow up was 19.1 months. 4 dose levels (DLs) were evaluate …
INTRODUCTION: Metastatic uveal melanoma (MUM) has a poor prognosis and treatment options are limited. These patients do not typically …
112 results