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233 results

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Quoted phrase not found in phrase index: "Primary release disorder of platelets"
Page 1
AGA Clinical Practice Update: Coagulation in Cirrhosis.
O'Leary JG, Greenberg CS, Patton HM, Caldwell SH. O'Leary JG, et al. Gastroenterology. 2019 Jul;157(1):34-43.e1. doi: 10.1053/j.gastro.2019.03.070. Epub 2019 Apr 12. Gastroenterology. 2019. PMID: 30986390 Review.
BEST PRACTICE ADVICE 4: The following transfusion thresholds for management of active bleeding or high-risk procedures may optimize clot formation in advanced liver disease: hematocrit 25%, platelet count >50,000, and fibrinogen >120 mg/dL. ...Neither is belie …
BEST PRACTICE ADVICE 4: The following transfusion thresholds for management of active bleeding or high-risk procedures may optimize clot for …
Long-term clinical outcomes of tisagenlecleucel in patients with relapsed or refractory aggressive B-cell lymphomas (JULIET): a multicentre, open-label, single-arm, phase 2 study.
Schuster SJ, Tam CS, Borchmann P, Worel N, McGuirk JP, Holte H, Waller EK, Jaglowski S, Bishop MR, Damon LE, Foley SR, Westin JR, Fleury I, Ho PJ, Mielke S, Teshima T, Janakiram M, Hsu JM, Izutsu K, Kersten MJ, Ghosh M, Wagner-Johnston N, Kato K, Corradini P, Martinez-Prieto M, Han X, Tiwari R, Salles G, Maziarz RT. Schuster SJ, et al. Lancet Oncol. 2021 Oct;22(10):1403-1415. doi: 10.1016/S1470-2045(21)00375-2. Epub 2021 Sep 10. Lancet Oncol. 2021. PMID: 34516954 Clinical Trial.
BACKGROUND: In the primary analysis of the pivotal JULIET trial of tisagenlecleucel, an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, the best overall response rate was 52% and the complete response rate was 40% in 93 evaluable adult patients …
BACKGROUND: In the primary analysis of the pivotal JULIET trial of tisagenlecleucel, an autologous anti-CD19 chimeric antigen …
Cancer-associated venous thromboembolism: Burden, mechanisms, and management.
Ay C, Pabinger I, Cohen AT. Ay C, et al. Thromb Haemost. 2017 Jan 26;117(2):219-230. doi: 10.1160/TH16-08-0615. Epub 2016 Nov 24. Thromb Haemost. 2017. PMID: 27882374 Review.
In this review, we discuss the epidemiology and burden of the disease, the pathophysiology of cancer-associated VTE, and the clinical treatment options for both primary prevention and acute treatment. ...Furthermore, blood count parameters (e.g. pla …
In this review, we discuss the epidemiology and burden of the disease, the pathophysiology of cancer-associated VTE, and the clini …
Splinting for carpal tunnel syndrome.
Karjalainen TV, Lusa V, Page MJ, O'Connor D, Massy-Westropp N, Peters SE. Karjalainen TV, et al. Cochrane Database Syst Rev. 2023 Feb 27;2(2):CD010003. doi: 10.1002/14651858.CD010003.pub2. Cochrane Database Syst Rev. 2023. PMID: 36848651 Free PMC article. Review.
We excluded participants if they had previously undergone surgical release. DATA COLLECTION AND ANALYSIS: Review authors independently selected trials for inclusion, extracted data, assessed study risk of bias and the certainty in the body of evidence for primary ou …
We excluded participants if they had previously undergone surgical release. DATA COLLECTION AND ANALYSIS: Review authors independentl …
Local and Targeted Delivery of Immune Checkpoint Blockade Therapeutics.
Han X, Li H, Zhou D, Chen Z, Gu Z. Han X, et al. Acc Chem Res. 2020 Nov 17;53(11):2521-2533. doi: 10.1021/acs.accounts.0c00339. Epub 2020 Oct 19. Acc Chem Res. 2020. PMID: 33073988 Free PMC article.
Microneedles provided microchannels to facilitate the transdermal transport of CAP and further induce immunogenic tumor cell death, which could be synergized by the local release of aPD-L1. In addition, in situ formed injectable or sprayable hydrogels were tailored to deli …
Microneedles provided microchannels to facilitate the transdermal transport of CAP and further induce immunogenic tumor cell death, which co …
The key contribution of platelet and vascular arachidonic acid metabolism to the pathophysiology of atherothrombosis.
Badimon L, Vilahur G, Rocca B, Patrono C. Badimon L, et al. Cardiovasc Res. 2021 Jul 27;117(9):2001-2015. doi: 10.1093/cvr/cvab003. Cardiovasc Res. 2021. PMID: 33484117 Review.
Arachidonic acid is one of the most abundant and ubiquitous omega-6 polyunsaturated fatty acid, present in esterified form in the membrane phospholipids of all mammalian cells and released from phospholipids by several phospholipases in response to various activating or in …
Arachidonic acid is one of the most abundant and ubiquitous omega-6 polyunsaturated fatty acid, present in esterified form in the membrane p …
Current applications of platelet gels in wound healing-A review.
Wang S, Yang J, Zhao G, Liu R, Du Y, Cai Z, Luan J, Shen Y, Chen B. Wang S, et al. Wound Repair Regen. 2021 May;29(3):370-379. doi: 10.1111/wrr.12896. Epub 2021 Mar 22. Wound Repair Regen. 2021. PMID: 33749992 Review.
Platelet concentrates are activated with thrombin or calcium, resulting in a viscous coagulum (platelet gel [PG]), composed of 95% platelets at least. ...This review addresses a variety of aspects relevant to the functions of well-known platelet growth …
Platelet concentrates are activated with thrombin or calcium, resulting in a viscous coagulum (platelet gel [PG]), composed of …
Vascular endothelium - Gatekeeper of vessel health.
Cahill PA, Redmond EM. Cahill PA, et al. Atherosclerosis. 2016 May;248:97-109. doi: 10.1016/j.atherosclerosis.2016.03.007. Epub 2016 Mar 9. Atherosclerosis. 2016. PMID: 26994427 Free PMC article. Review.
The vascular endothelium is an interface between the blood stream and the vessel wall. Changes in this single cell layer of the artery wall are believed of primary importance in the pathogenesis of vascular disease/atherosclerosis. The endothelium responds to …
The vascular endothelium is an interface between the blood stream and the vessel wall. Changes in this single cell layer of the arter …
Serotonin and Raynaud's phenomenon.
Seibold JR. Seibold JR. J Cardiovasc Pharmacol. 1985;7 Suppl 7:S95-8. J Cardiovasc Pharmacol. 1985. PMID: 2412070 Review.
No single pathophysiologic mechanism explains adequately cold-induced vasospasm in all forms of Raynaud's phenomenon. Local serotonin release from activated platelets is a contributory element in those disorders typified by structural arterial change, e.g., s …
No single pathophysiologic mechanism explains adequately cold-induced vasospasm in all forms of Raynaud's phenomenon. Local serotonin rel …
Yosprala: A Fixed Dose Combination of Aspirin and Omeprazole.
Veltri KT. Veltri KT. Cardiol Rev. 2018 Jan/Feb;26(1):50-53. doi: 10.1097/CRD.0000000000000174. Cardiol Rev. 2018. PMID: 29045287 Review.
Cardiovascular disease is the leading cause of morbidity and mortality in the United States. ...The US Food and Drug Administration approved Yosprala (Aralez Pharmaceuticals), a fixed-dose combination of delayed-release aspirin and immediate-release omeprazol …
Cardiovascular disease is the leading cause of morbidity and mortality in the United States. ...The US Food and Drug Administration a …
233 results