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Quoted phrase not found in phrase index: "Prolonged G2 phase of cell cycle"
Page 1
Cells and polyamines do it cyclically.
Alm K, Oredsson S. Alm K, et al. Essays Biochem. 2009 Nov 4;46:63-76. doi: 10.1042/bse0460005. Essays Biochem. 2009. PMID: 20095970 Review.
One of the major events of the cell cycle is the duplication of DNA during S-phase. A group of molecules that are important for proper cell-cycle progression is the polyamines. ...When cells in G(0)/G(1) -phase are seeded in the presence …
One of the major events of the cell cycle is the duplication of DNA during S-phase. A group of molecules that are impor …
Effects of ethephon on serum levels of sex hormone, apoptosis, and cell cycle of ovaries in mice.
Huang H, Zhao X, Shi X, Tan Q, Zhang R, Yue M, Ma R, Chen Q, Zhao S, Yang L. Huang H, et al. Endokrynol Pol. 2022;73(2):346-352. doi: 10.5603/EP.a2022.0025. Endokrynol Pol. 2022. PMID: 35593683 Free article.
Enzyme-linked immunoassay was used to detect the serum levels of serum sex hormones. The cell cycle distribution and rate of apoptosis of mouse ovarian tissues were examined using flow cytometry. ...In addition, ethephon significantly inhibited the apoptosis rate in …
Enzyme-linked immunoassay was used to detect the serum levels of serum sex hormones. The cell cycle distribution and rate of a …
Development and structure-activity relationship of tacrine derivatives as highly potent CDK2/9 inhibitors for the treatment of cancer.
Wu L, Liu W, Huang Y, Zhu C, Ma Q, Wu Q, Tian L, Feng X, Liu M, Wang N, Xu X, Liu X, Xu C, Qiu J, Xu Z, Liu W, Zhao Q. Wu L, et al. Eur J Med Chem. 2022 Nov 15;242:114701. doi: 10.1016/j.ejmech.2022.114701. Epub 2022 Aug 28. Eur J Med Chem. 2022. PMID: 36054949
CDK2/9 are members of the CDKs family, which play key roles in the occurrence and development of many cancers by regulating cell cycle and transcriptional prolongation, respectively. To further optimize and discuss the structure-activity relationships (SARs), …
CDK2/9 are members of the CDKs family, which play key roles in the occurrence and development of many cancers by regulating cell c …
Lenalidomide for treatment of myelodysplastic syndromes: current status and future directions.
Komrokji RS, List AF. Komrokji RS, et al. Hematol Oncol Clin North Am. 2010 Apr;24(2):377-88. doi: 10.1016/j.hoc.2010.02.013. Hematol Oncol Clin North Am. 2010. PMID: 20359632 Review.
Lenalidomide was approved by the US Food and Drug Administration (FDA) for treatment of transfusion-dependent lower-risk myelodysplastic syndrome patients with deletion (del) (5q) alone or with additional karyotype abnormalities. The approval was based on high rates of prolong …
Lenalidomide was approved by the US Food and Drug Administration (FDA) for treatment of transfusion-dependent lower-risk myelodysplastic syn …
Synthesis of novel morpholine conjugated benzophenone analogues and evaluation of antagonistic role against neoplastic development.
Al-Ghorbani M, Thirusangu P, Gurupadaswamy HD, Vigneshwaran V, Mohammed YH, Prabhakar BT, Khanum SA. Al-Ghorbani M, et al. Bioorg Chem. 2017 Apr;71:55-66. doi: 10.1016/j.bioorg.2017.01.011. Epub 2017 Jan 18. Bioorg Chem. 2017. PMID: 28139247
From the cytotoxic studies and structural activity relationship of compounds 8a-j, it is clear that methyl group on the B ring of benzophenone is essential for antiproliferative activity and bromo at ortho position (compound 8b) and methyl at para position (compound 8f) on A ring …
From the cytotoxic studies and structural activity relationship of compounds 8a-j, it is clear that methyl group on the B ring of benzopheno …
Arecoline induced cell cycle arrest, apoptosis, and cytotoxicity to human endothelial cells.
Tseng SK, Chang MC, Su CY, Chi LY, Chang JZ, Tseng WY, Yeung SY, Hsu ML, Jeng JH. Tseng SK, et al. Clin Oral Investig. 2012 Aug;16(4):1267-73. doi: 10.1007/s00784-011-0604-1. Epub 2011 Aug 17. Clin Oral Investig. 2012. PMID: 21847594
Cytotoxicity was estimated by 3-(4, 5- dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide assay. The cell cycle distribution of EAHY cells residing in sub-G0/G1, G0/G1, S-, and G2/M phases was analyzed by propidium iodide staining of cellular DNA content …
Cytotoxicity was estimated by 3-(4, 5- dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide assay. The cell cycle distribut …
Exploiting epigenetic targets to overcome taxane resistance in prostate cancer.
Cevatemre B, Bulut I, Dedeoglu B, Isiklar A, Syed H, Bayram OY, Bagci-Onder T, Acilan C. Cevatemre B, et al. Cell Death Dis. 2024 Feb 12;15(2):132. doi: 10.1038/s41419-024-06422-1. Cell Death Dis. 2024. PMID: 38346967 Free PMC article.
The development of taxane resistance remains a major challenge for castration resistant prostate cancer (CR-PCa), despite the effectiveness of taxanes in prolonging patient survival. To uncover novel targets, we performed an epigenetic drug screen on taxane (docetaxel and …
The development of taxane resistance remains a major challenge for castration resistant prostate cancer (CR-PCa), despite the effectiveness …
Downregulation of Survivin by shRNA Inhibits Invasion and Enhances the Radiosensitivity of Laryngeal Squamous Cell Carcinoma.
Hu J, Pan J, Luo Z, Tao Z. Hu J, et al. Cell Biochem Biophys. 2015 May;72(1):251-7. doi: 10.1007/s12013-014-0445-z. Cell Biochem Biophys. 2015. PMID: 25701406
In addition, shRNA-targeting survivin abrogated radiation-induced G2 phase arrest and amplified radiation-induced apoptosis. In vivo, shRNA transfection also sensitized tumor xenograft to radiotherapy. Radioresistance of laryngeal squamous cell carcinoma may …
In addition, shRNA-targeting survivin abrogated radiation-induced G2 phase arrest and amplified radiation-induced apoptosis. I …
Influence of flavonoids on cell cycle phase as analyzed by flow-cytometry.
Koide T, Kamei H, Hashimoto Y, Kojima T, Terabe K, Umeda T. Koide T, et al. Cancer Biother Radiopharm. 1997 Apr;12(2):111-5. doi: 10.1089/cbr.1997.12.111. Cancer Biother Radiopharm. 1997. PMID: 10851454
Flavonoids were previously reported to have cytostatic activity in vitro and in vivo. In the present study each phase of the cell cycle was observed by flow-cytometry after HCT-15 cells had been cultured with flavonoids for 2 days. ...Delphinidin gave a high …
Flavonoids were previously reported to have cytostatic activity in vitro and in vivo. In the present study each phase of the cell …
Pragmatic recruitment of memantine as the capping group for the design of HDAC inhibitors: A preliminary attempt to unravel the enigma of glioblastoma.
Nepali K, Hsu TI, Hsieh CM, Lo WL, Lai MJ, Hsu KC, Lin TE, Chuang JY, Liou JP. Nepali K, et al. Eur J Med Chem. 2021 May 5;217:113338. doi: 10.1016/j.ejmech.2021.113338. Epub 2021 Mar 12. Eur J Med Chem. 2021. PMID: 33744690
Furthermore, 16 exerted cell cycle arrest at G2 phase, induced apoptosis in GBM cells at high concentration and exhibited high BBB permeability. To add on, in-vivo study revealed that the administration of compound 16 prolonged the survival of T …
Furthermore, 16 exerted cell cycle arrest at G2 phase, induced apoptosis in GBM cells at high concentration and …
59 results