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Year Number of Results
2005 2
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2008 1
2009 1
2011 4
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Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome.
Sun L, Ma W, Gao W, Xing Y, Chen L, Xia Z, Zhang Z, Dai Z. Sun L, et al. Cell Death Dis. 2019 Jul 17;10(8):542. doi: 10.1038/s41419-019-1761-4. Cell Death Dis. 2019. PMID: 31316052 Free PMC article.
Propofol infusion syndrome (PRIS) is an uncommon life-threatening complication observed most often in patients receiving high-dose propofol. ...However, the associated molecular mechanisms remain unclear. An increasing number of clinical and experiment …
Propofol infusion syndrome (PRIS) is an uncommon life-threatening complication observed most often in patients r …
The incidence of propofol infusion syndrome in critically-ill patients.
Li WK, Chen XJC, Altshuler D, Islam S, Spiegler P, Emerson L, Bender M. Li WK, et al. J Crit Care. 2022 Oct;71:154098. doi: 10.1016/j.jcrc.2022.154098. Epub 2022 Jun 17. J Crit Care. 2022. PMID: 35724444
In PRIS patients, propofol was administered at a median dose of 36.4 mug/kg/min and over a median duration of 147.0 h. The development of PRIS was observed at a median of 125.0 h post-propofol initiation and a cumulative dose of 276.5 mg/kg. The development of metabolic ac …
In PRIS patients, propofol was administered at a median dose of 36.4 mug/kg/min and over a median duration of 147.0 h. The development of PR …
Suspected propofol infusion syndrome during normal targeted propofol concentration.
Ichikawa T, Okuyama K, Kamata K, Masui K, Ozaki M. Ichikawa T, et al. J Anesth. 2020 Aug;34(4):619-623. doi: 10.1007/s00540-020-02773-z. Epub 2020 Mar 28. J Anesth. 2020. PMID: 32222909
To this day, the pathophysiology and risk factors of propofol infusion syndrome (PRIS) remain unknown. Moreover, there is no widely accepted definition of PRIS, even though it is a potentially fatal condition. ...In this clinical report, we described the firs …
To this day, the pathophysiology and risk factors of propofol infusion syndrome (PRIS) remain unknown. Moreover, there …
Modeling propofol-induced cardiotoxicity in the isolated-perfused newborn mouse heart.
Barajas MB, Wang A, Griffiths KK, Sun L, Yang G, Levy RJ. Barajas MB, et al. Physiol Rep. 2022 Aug;10(15):e15402. doi: 10.14814/phy2.15402. Physiol Rep. 2022. PMID: 35923108 Free PMC article.
Infants and children are vulnerable to developing propofol infusion syndrome (PRIS) and young age is a risk factor. Cardiac involvement is often prominent and associated with death. ...We hypothesized that the model would recapitulate the key cardiac features …
Infants and children are vulnerable to developing propofol infusion syndrome (PRIS) and young age is a risk factor. Car …
Cardiovascular manifestations of sedatives and analgesics in the critical care unit.
Darrouj J, Karma L, Arora R. Darrouj J, et al. Am J Ther. 2009 Jul-Aug;16(4):339-53. doi: 10.1097/01.pap.0000249925.76324.47. Am J Ther. 2009. PMID: 19092649 Review.
Morphine provides analgesia and cardioprotective activity after ischemia, although the large observational study CRUSADE showed increased mortality rate in those patients with non-ST segment elevation myocardial infarction who received morphine. Propofol is the most easily …
Morphine provides analgesia and cardioprotective activity after ischemia, although the large observational study CRUSADE showed incre …
Propofol for Anesthesia in Pediatric Patients With Epilepsy on the Ketogenic Diet: A Single-Center Experience.
Bui PH, Handoko M, Diaz-Medina G, Ng AS, Katyayan A. Bui PH, et al. Pediatr Neurol. 2023 Dec;149:63-68. doi: 10.1016/j.pediatrneurol.2023.08.031. Epub 2023 Aug 25. Pediatr Neurol. 2023. PMID: 37806040
BACKGROUND: Propofol use is contraindicated in patients on ketogenic diet (KD) due to higher risk of propofol infusion syndrome (PIS). This study is intended to provide a descriptive analysis of our experience with propofol bolus and short infusions for anest …
BACKGROUND: Propofol use is contraindicated in patients on ketogenic diet (KD) due to higher risk of propofol infusion synd …
Treatment strategies for refractory status epilepticus.
Holtkamp M. Holtkamp M. Curr Opin Crit Care. 2011 Apr;17(2):94-100. doi: 10.1097/MCC.0b013e328342fab5. Curr Opin Crit Care. 2011. PMID: 21178612 Review.
The latter are associated with prolonged ventilation times due to redistribution kinetics, whereas the former bears the risk of propofol infusion syndrome if administered continuously. Even after prolonged treatment with anesthetics over weeks, survival with …
The latter are associated with prolonged ventilation times due to redistribution kinetics, whereas the former bears the risk of propofol …
Effects of Propofol on Cellular Bioenergetics in Human Skeletal Muscle Cells.
Krajčová A, Løvsletten NG, Waldauf P, Frič V, Elkalaf M, Urban T, Anděl M, Trnka J, Thoresen GH, Duška F. Krajčová A, et al. Crit Care Med. 2018 Mar;46(3):e206-e212. doi: 10.1097/CCM.0000000000002875. Crit Care Med. 2018. PMID: 29240609
OBJECTIVES: Propofol may adversely affect the function of mitochondria and the clinical features of propofol infusion syndrome suggest that this may be linked to propofol-related bioenergetic failure. ...Addition of extra fatty acids into the media counteract …
OBJECTIVES: Propofol may adversely affect the function of mitochondria and the clinical features of propofol infusion syndr …
Fospropofol disodium versus propofol for long-term sedation during invasive mechanical ventilation: A pilot randomized clinical trial.
Gao X, Yang X, Tang Y, Fang X, Yuan Y, Qi H, Li R, Shu H, Zou X, Shang Y. Gao X, et al. J Clin Anesth. 2024 Aug;95:111442. doi: 10.1016/j.jclinane.2024.111442. Epub 2024 Mar 16. J Clin Anesth. 2024. PMID: 38493706 Clinical Trial.
INTERVENTIONS: The fospropofol group received continuous fospropofol disodium infusions and the propofol group received continuous propofol infusions. The sedation goal was a score of -3 to 0 on the Richmond Agitation and Sedation Scale (RASS). ...The most common adverse e …
INTERVENTIONS: The fospropofol group received continuous fospropofol disodium infusions and the propofol group received continuous propofol …
Inhalational anaesthetics in the ICU: theory and practice of inhalational sedation in the ICU, economics, risk-benefit.
Meiser A, Laubenthal H. Meiser A, et al. Best Pract Res Clin Anaesthesiol. 2005 Sep;19(3):523-38. doi: 10.1016/j.bpa.2005.02.006. Best Pract Res Clin Anaesthesiol. 2005. PMID: 16013698 Review.
The incidence of post-traumatic stress disorder after long-term sedation is high. The recent focus on propofol infusion syndrome entails restrictions in the use of this drug. ...Respiration and intestinal motility are not depressed, facilitating modern therap …
The incidence of post-traumatic stress disorder after long-term sedation is high. The recent focus on propofol infusion syn …
22 results