Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1965 7
1966 19
1967 18
1968 11
1969 9
1970 6
1971 17
1972 6
1973 5
1974 10
1975 10
1976 6
1977 11
1978 7
1979 4
1980 3
1981 3
1982 3
1983 3
1984 2
1985 2
1986 1
1987 3
1988 3
1990 1
1991 4
1992 3
1993 2
1994 1
1995 1
1996 2
1997 1
1998 5
2000 2
2001 6
2004 1
2005 1
2006 1
2007 1
2008 2
2009 1
2010 3
2012 2
2013 2
2014 4
2015 5
2016 3
2017 3
2018 5
2019 4
2020 8
2021 6
2022 10
2023 8
2024 2

Text availability

Article attribute

Article type

Publication date

Search Results

258 results

Results by year

Filters applied: . Clear all
Page 1
Proscillaridin A Sensitizes Human Colon Cancer Cells to TRAIL-Induced Cell Death.
Semba M, Takamatsu S, Komazawa-Sakon S, Miyoshi E, Nishiyama C, Nakano H, Moriwaki K. Semba M, et al. Int J Mol Sci. 2022 Jun 23;23(13):6973. doi: 10.3390/ijms23136973. Int J Mol Sci. 2022. PMID: 35805980 Free PMC article.
Proscillaridin A synergistically enhanced TRAIL-induced cell death in TRAIL-sensitive and -resistant colon cancer cells. ...Furthermore, proscillaridin A enhanced TRAIL-induced cell death partly via O-glycosylation. ...
Proscillaridin A synergistically enhanced TRAIL-induced cell death in TRAIL-sensitive and -resistant colon cancer cells. ...Furthermo …
Repurposing proscillaridin A in combination with decitabine against embryonal rhabdomyosarcoma RD cells.
Huot M, Caron M, Richer C, Djibo R, Najmanovich R, St-Onge P, Sinnett D, Raynal NJM. Huot M, et al. Cancer Chemother Pharmacol. 2021 Nov;88(5):845-856. doi: 10.1007/s00280-021-04339-6. Epub 2021 Jul 31. Cancer Chemother Pharmacol. 2021. PMID: 34331108
We also reported that decitabine, a hypomethylating drug, synergizes with proscillaridin A in colon cancer cells. Here, we investigated whether proscillaridin A exhibits epigenetic and anticancer activity against eRMS RD cells, overexpressing MYC oncogene, and its c …
We also reported that decitabine, a hypomethylating drug, synergizes with proscillaridin A in colon cancer cells. Here, we investigat …
Proscillaridin A induces apoptosis and inhibits the metastasis of osteosarcoma in vitro and in vivo.
Fang S, Tao H, Xia K, Guo W. Fang S, et al. Biochem Biophys Res Commun. 2020 Jan 22;521(4):880-886. doi: 10.1016/j.bbrc.2019.11.012. Epub 2019 Nov 7. Biochem Biophys Res Commun. 2020. PMID: 31708095
In the present study, we assessed the effects of Proscillaridin A on osteosarcoma and investigated its underlying action mechanism. ...Also, flow cytometry and invasion assay revealed that Proscillaridin A induced apoptosis and reduced 143B cell motility. Western bl …
In the present study, we assessed the effects of Proscillaridin A on osteosarcoma and investigated its underlying action mechanism. . …
Proscillaridin A inhibits lung cancer cell growth and motility through downregulation of the EGFR-Src-associated pathway.
Tsai JY, Weng CW, Lai YH, Tsai MF, Chen HY, Chen JJ. Tsai JY, et al. Am J Cancer Res. 2023 Nov 15;13(11):5352-5367. eCollection 2023. Am J Cancer Res. 2023. PMID: 38058797 Free PMC article.
This study aimed to investigate the functional role and mechanism of proscillaridin A in NSCLC with or without EGFR mutations. Cellular function assays showed that proscillaridin A could inhibit cell proliferation, migration and invasion in vitro independent of EGFR …
This study aimed to investigate the functional role and mechanism of proscillaridin A in NSCLC with or without EGFR mutations. Cellul …
Proscillaridin A inhibits hepatocellular carcinoma progression through inducing mitochondrial damage and autophagy.
Luo M, Liu Y, Liu N, Shao W, Ming L, Liu J, Xie Y. Luo M, et al. Acta Biochim Biophys Sin (Shanghai). 2021 Jan 12;53(1):19-28. doi: 10.1093/abbs/gmaa139. Acta Biochim Biophys Sin (Shanghai). 2021. PMID: 33201987 Free article.
There is an urgent need to develop additional effective drugs for HCC treatment. In the present study, we found that proscillaridin A (ProA), a cardiac glycoside, exerted a strong anticancer effect on multiple HCC cell lines. ...
There is an urgent need to develop additional effective drugs for HCC treatment. In the present study, we found that proscillaridin A …
Proscillaridin A induces mitochondrial damage and autophagy in pancreatic cancer and reduces the stability of SMAD4 in Panc-1 cells.
Hou J, Kang N, Liu NN, Tan D, Zhang S, Liu J, Xie Y. Hou J, et al. Ann Transl Med. 2022 Aug;10(15):820. doi: 10.21037/atm-22-1085. Ann Transl Med. 2022. PMID: 36034984 Free PMC article.
Cardiac glycosides (CGs) have been traditionally used for their potent cardiovascular activities and have also recently been reported to exhibit anti-tumor effects. Proscillaridin A (Pro A), a natural CG, has been shown to display anti-tumor effects on multiple cancer type …
Cardiac glycosides (CGs) have been traditionally used for their potent cardiovascular activities and have also recently been reported to exh …
Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation.
Da Costa EM, Armaos G, McInnes G, Beaudry A, Moquin-Beaudry G, Bertrand-Lehouillier V, Caron M, Richer C, St-Onge P, Johnson JR, Krogan N, Sai Y, Downey M, Rafei M, Boileau M, Eppert K, Flores-Díaz E, Haman A, Hoang T, Sinnett D, Beauséjour C, McGraw S, Raynal NJ. Da Costa EM, et al. J Exp Clin Cancer Res. 2019 Jun 13;38(1):251. doi: 10.1186/s13046-019-1242-8. J Exp Clin Cancer Res. 2019. PMID: 31196146 Free PMC article.
METHODS: Proscillaridin A anticancer activity was investigated against a panel of human leukemia and solid tumor cell lines with different MYC expression levels, overexpression in vitro systems and leukemia stem cells. ...CONCLUSION: Overall, these results strongly support …
METHODS: Proscillaridin A anticancer activity was investigated against a panel of human leukemia and solid tumor cell lines with diff …
Proscillaridin A slows the prostate cancer progression through triggering the activation of endoplasmic reticulum stress.
Wang F, Liu L, Tong Y, Li L, Liu Y, Gao WQ. Wang F, et al. Cell Cycle. 2020 Mar;19(5):541-550. doi: 10.1080/15384101.2020.1716484. Epub 2020 Feb 2. Cell Cycle. 2020. PMID: 32009541 Free PMC article.
Although androgen deprivation therapy for advanced PCa patients has significantly improved their survival, the majority of these patients eventually develop castration-resistant prostate cancer (CRPC). Proscillaridin A (Pro A), a cardiac glycoside that is clinically used t …
Although androgen deprivation therapy for advanced PCa patients has significantly improved their survival, the majority of these patients ev …
Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo.
Denicolaï E, Baeza-Kallee N, Tchoghandjian A, Carré M, Colin C, Jiglaire CJ, Mercurio S, Beclin C, Figarella-Branger D. Denicolaï E, et al. Oncotarget. 2014 Nov 15;5(21):10934-48. doi: 10.18632/oncotarget.2541. Oncotarget. 2014. PMID: 25400117 Free PMC article.
In vitro effects of proscillaridin A were evaluated on GBM6 and GBM9 stem-like cell lines and on U87-MG and U251-MG cell lines. ...Altogether, results suggest that proscillaridin A is a promising candidate as cancer therapies in glioblastoma. ...
In vitro effects of proscillaridin A were evaluated on GBM6 and GBM9 stem-like cell lines and on U87-MG and U251-MG cell lines. ...Al …
Proscillaridin A exerts anti-tumor effects through GSK3beta activation and alteration of microtubule dynamics in glioblastoma.
Berges R, Denicolai E, Tchoghandjian A, Baeza-Kallee N, Honore S, Figarella-Branger D, Braguer D. Berges R, et al. Cell Death Dis. 2018 Sep 24;9(10):984. doi: 10.1038/s41419-018-1018-7. Cell Death Dis. 2018. PMID: 30250248 Free PMC article.
Due to the highly lethal nature of GBM, new therapies are urgently needed and repositioning of existing drugs is a promising approach. We have previously shown the activity of Proscillaridin A (ProA), a cardiac glycoside inhibitor of the Na(+)/K(+) ATPase (NKA) pump, again …
Due to the highly lethal nature of GBM, new therapies are urgently needed and repositioning of existing drugs is a promising approach. We ha …
258 results