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Quoted phrase not found in phrase index: "Prostate Carcinoma by Gene Expression Profile"
Page 1
FOXA2 drives lineage plasticity and KIT pathway activation in neuroendocrine prostate cancer.
Han M, Li F, Zhang Y, Dai P, He J, Li Y, Zhu Y, Zheng J, Huang H, Bai F, Gao D. Han M, et al. Cancer Cell. 2022 Nov 14;40(11):1306-1323.e8. doi: 10.1016/j.ccell.2022.10.011. Epub 2022 Nov 3. Cancer Cell. 2022. PMID: 36332622 Free article.
Here, using single-cell multiomics analyses, we investigate the dynamics of cellular heterogeneity, transcriptome regulation, and microenvironmental factors in 107,201 cells from genetically engineered mouse prostate cancer samples with complete time series of tumor …
Here, using single-cell multiomics analyses, we investigate the dynamics of cellular heterogeneity, transcriptome regulation, and mic …
B7-H3 as a Therapeutic Target in Advanced Prostate Cancer.
Guo C, Figueiredo I, Gurel B, Neeb A, Seed G, Crespo M, Carreira S, Rekowski J, Buroni L, Welti J, Bogdan D, Gallagher L, Sharp A, Fenor de la Maza MD, Rescigno P, Westaby D, Chandran K, Riisnaes R, Ferreira A, Miranda S, Calì B, Alimonti A, Bressan S, Nguyen AHT, Shen MM, Hawley JE, Obradovic A, Drake CG, Bertan C, Baker C, Tunariu N, Yuan W, de Bono JS. Guo C, et al. Eur Urol. 2023 Mar;83(3):224-238. doi: 10.1016/j.eururo.2022.09.004. Epub 2022 Sep 13. Eur Urol. 2023. PMID: 36114082 Free article.
BACKGROUND: B7-H3 is a cell surface immunomodulatory glycoprotein overexpressed in prostate cancers (PCs). Understanding its longitudinal expression at emergence of castration resistance and association with tumour genomics are critical to the development of and pat …
BACKGROUND: B7-H3 is a cell surface immunomodulatory glycoprotein overexpressed in prostate cancers (PCs). Understanding its longitud …
Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study.
Aggarwal R, Huang J, Alumkal JJ, Zhang L, Feng FY, Thomas GV, Weinstein AS, Friedl V, Zhang C, Witte ON, Lloyd P, Gleave M, Evans CP, Youngren J, Beer TM, Rettig M, Wong CK, True L, Foye A, Playdle D, Ryan CJ, Lara P, Chi KN, Uzunangelov V, Sokolov A, Newton Y, Beltran H, Demichelis F, Rubin MA, Stuart JM, Small EJ. Aggarwal R, et al. J Clin Oncol. 2018 Aug 20;36(24):2492-2503. doi: 10.1200/JCO.2017.77.6880. Epub 2018 Jul 9. J Clin Oncol. 2018. PMID: 29985747 Free PMC article. Clinical Trial.
We sought to characterize the clinical and genomic features of t-SCNC in a multi-institutional prospective study. Methods Patients with progressive, metastatic castration-resistant prostate cancer (mCRPC) underwent metastatic tumor biopsy and were followed for survi …
We sought to characterize the clinical and genomic features of t-SCNC in a multi-institutional prospective study. Methods Patients wi …
Prostate epithelial genes define therapy-relevant prostate cancer molecular subtype.
Han H, Lee HH, Choi K, Moon YJ, Heo JE, Ham WS, Jang WS, Rha KH, Cho NH, Giancotti FG, Choi YD. Han H, et al. Prostate Cancer Prostatic Dis. 2021 Dec;24(4):1080-1092. doi: 10.1038/s41391-021-00364-x. Epub 2021 Apr 26. Prostate Cancer Prostatic Dis. 2021. PMID: 33903734 Free PMC article.
However, unsupervised clustering analysis is hindered by potential confounding factors such as stromal contamination and stress-related material degradation. MATERIALS AND METHODS: To focus on prostate epithelial cell-relevant heterogeneity, we defined 1,629 genes expresse …
However, unsupervised clustering analysis is hindered by potential confounding factors such as stromal contamination and stress-related mate …
Androgen deprivation modulates gene expression profile along prostate cancer progression.
Volante M, Tota D, Giorcelli J, Bollito E, Napoli F, Vatrano S, Buttigliero C, Molinaro L, Gontero P, Porpiglia F, Tucci M, Papotti M, Berruti A, Rapa I. Volante M, et al. Hum Pathol. 2016 Oct;56:81-8. doi: 10.1016/j.humpath.2016.06.004. Epub 2016 Jun 21. Hum Pathol. 2016. PMID: 27342909
The correlation between biopsy and surgical samples was poor for most of the tested genes. Gene expression analysis of separate tumor areas from the same patient showed an extremely heterogeneous profile in the 6 tested cases (all untreated). ...However, intr …
The correlation between biopsy and surgical samples was poor for most of the tested genes. Gene expression analysis of separat …
New insights into molecular and cellular mechanisms of zoledronate in human osteosarcoma.
Lu KH, Lu EW, Lin CW, Yang JS, Yang SF. Lu KH, et al. Pharmacol Ther. 2020 Oct;214:107611. doi: 10.1016/j.pharmthera.2020.107611. Epub 2020 Jun 18. Pharmacol Ther. 2020. PMID: 32565177 Review.
The nitrogen-containing zoledronate, the third generation bisphosphonate (BP), effectively inhibits osteoclastic bone resorption and is widely utilized in the treatment of metabolic and metastatic bone diseases nowadays. Owing to an acceptable safety profile and tolerabili …
The nitrogen-containing zoledronate, the third generation bisphosphonate (BP), effectively inhibits osteoclastic bone resorption and is wide …
Anticancer properties and mechanism of action of the quassinoid ailanthone.
Bailly C. Bailly C. Phytother Res. 2020 Sep;34(9):2203-2213. doi: 10.1002/ptr.6681. Epub 2020 Apr 1. Phytother Res. 2020. PMID: 32239572 Review.
Potent in vivo activities have been evidenced in mice bearing hepatocellular carcinoma, nonsmall cell lung cancer and castration-resistant prostate cancer. This review focusses on the mechanism of action of AIT, notably to highlight the capacity of the drug to activ …
Potent in vivo activities have been evidenced in mice bearing hepatocellular carcinoma, nonsmall cell lung cancer and castration-resi …
Current and Future Applications of Novel Immunotherapies in Urological Oncology: A Critical Review of the Literature.
Özdemir BC, Siefker-Radtke AO, Campbell MT, Subudhi SK. Özdemir BC, et al. Eur Urol Focus. 2018 Apr;4(3):442-454. doi: 10.1016/j.euf.2017.10.001. Epub 2017 Oct 19. Eur Urol Focus. 2018. PMID: 29056275 Review.
EVIDENCE ACQUISITION: We reviewed related literature, with a focus on recent studies about immunotherapies, predictors of response, and ongoing clinical trials. EVIDENCE SYNTHESIS: Immunotherapies based on immune checkpoint blockade are approved as first- and second-line t …
EVIDENCE ACQUISITION: We reviewed related literature, with a focus on recent studies about immunotherapies, predictors of response, and ongo …
High-fat diet-induced hyperinsulinemia promotes the development of prostate adenocarcinoma in prostate-specific Pten-/- mice.
Wang H, Yan W, Sun Y, Yang CS. Wang H, et al. Carcinogenesis. 2022 Jun 4;43(5):504-516. doi: 10.1093/carcin/bgac013. Carcinogenesis. 2022. PMID: 35104315
However, it is unclear how they are associated with increased risk of prostate cancer. To elucidate the mechanistic link between MetS and prostate carcinogenesis, we characterized the development of MetS and prostate adenocarcinoma in prostate-specific …
However, it is unclear how they are associated with increased risk of prostate cancer. To elucidate the mechanistic link between MetS …
Peripheral gene signatures reveal distinct cancer patient immunotypes with therapeutic implications for autologous DC-based vaccines.
Hensler M, Rakova J, Kasikova L, Lanickova T, Pasulka J, Holicek P, Hraska M, Hrnciarova T, Kadlecova P, Schoenenberger A, Sochorova K, Rozkova D, Sojka L, Drozenova J, Laco J, Horvath R, Podrazil M, Hongyan G, Brtnicky T, Halaska MJ, Rob L, Ryska A, Coosemans A, Vergote I, Garg AD, Cibula D, Bartunkova J, Spisek R, Fucikova J. Hensler M, et al. Oncoimmunology. 2022 Jul 22;11(1):2101596. doi: 10.1080/2162402X.2022.2101596. eCollection 2022. Oncoimmunology. 2022. PMID: 35898703 Free PMC article.
An autologous DC-based vaccine (DCVAC) has recently been shown to improve progression-free survival and overall survival in randomized clinical trials enrolling patients with lung cancer (SLU01, NCT02470468) or ovarian carcinoma (SOV01, NCT02107937), but not …
An autologous DC-based vaccine (DCVAC) has recently been shown to improve progression-free survival and overall survival in randomized …
37 results