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Transport Behavior of Commercial Anticancer Drug Protein-Bound Paclitaxel (Paclicad) in a Micron-Sized Channel.
Prasad NK, Shome R, Biswas G, Ghosh SS, Dalal A. Prasad NK, et al. Langmuir. 2022 Feb 15;38(6):2014-2025. doi: 10.1021/acs.langmuir.1c02782. Epub 2022 Jan 31. Langmuir. 2022. PMID: 35099972
Protein-bound paclitaxel has been developed clinically as one of the most successful chemotherapy drugs for the treatment of a wide variety of cancers. ...Considering the detrimental impact of this restriction, we investigated the transport of protein- …
Protein-bound paclitaxel has been developed clinically as one of the most successful chemotherapy drugs for the treatme …
Immunotherapy for Breast Cancer: First FDA Approved Regimen.
Soare GR, Soare CA. Soare GR, et al. Discoveries (Craiova). 2019 Mar 31;7(1):e91. doi: 10.15190/d.2019.4. Discoveries (Craiova). 2019. PMID: 32309609 Free PMC article.
In March 2019, the US Food and Drug Administration granted accelerated approval for the first immunotherapy-based regimen comprising atezolizumab in combination with protein-bound paclitaxel for patients with advanced metastatic TNBC, expressing programmed ce …
In March 2019, the US Food and Drug Administration granted accelerated approval for the first immunotherapy-based regimen comprising atezoli …
Cost of home vs clinic administration of paclitaxel in metastatic breast cancer.
Sharma D, Wojtynek J, Fox KM, Cooper C, Dokubo I. Sharma D, et al. Am J Manag Care. 2021 Feb;27(2 Spec. No.):SP46-SP50. doi: 10.37765/ajmc.2021.88563. Epub 2020 Dec 24. Am J Manag Care. 2021. PMID: 33395244 Free article.
OBJECTIVES: To estimate the costs associated with home administration of oral paclitaxel and encequidar (novel P-glycoprotein pump inhibitor allowing oral paclitaxel bioavailability) compared with clinic/office administration of intravenous (IV) paclitaxel (175 mg/m2) and prot …
OBJECTIVES: To estimate the costs associated with home administration of oral paclitaxel and encequidar (novel P-glycoprotein pump inhibitor …
Hyperprogressive NSCLC With Two Immune-Checkpoint Inhibitors.
Kasparian S, Gentille C, Burns E, Bernicker EH. Kasparian S, et al. JTO Clin Res Rep. 2020 Feb 22;1(2):100017. doi: 10.1016/j.jtocrr.2020.100017. eCollection 2020 Jun. JTO Clin Res Rep. 2020. PMID: 34589924 Free PMC article.
His disease progressed markedly after the first cycle of immunotherapy. He was switched to carboplatin and protein-bound paclitaxel. He continued to have steady disease progression. ...
His disease progressed markedly after the first cycle of immunotherapy. He was switched to carboplatin and protein-bound pa …
Finding the Needle in the Haystack: Characterization of Trace Crystallinity in a Commercial Formulation of Paclitaxel Protein-Bound Particles by Raman Spectroscopy Enabled by Second Harmonic Generation Microscopy.
Schmitt PD, Trasi NS, Taylor LS, Simpson GJ. Schmitt PD, et al. Mol Pharm. 2015 Jul 6;12(7):2378-83. doi: 10.1021/acs.molpharmaceut.5b00065. Epub 2015 Jun 24. Mol Pharm. 2015. PMID: 26066072
Second harmonic generation (SHG) microscopy was used to rapidly identify regions of interest for localized confocal Raman spectroscopy measurements in order to quantify crystallinity within lyophilized Abraxane powder (protein bound paclitaxel for injectable …
Second harmonic generation (SHG) microscopy was used to rapidly identify regions of interest for localized confocal Raman spectroscopy measu …
Pharmacologic sensitivity of paclitaxel to its delivery vehicles drives distinct clinical outcomes of paclitaxel formulations.
Li Y, Chen N, Palmisano M, Zhou S. Li Y, et al. Mol Pharm. 2015 Apr 6;12(4):1308-17. doi: 10.1021/acs.molpharmaceut.5b00026. Epub 2015 Mar 16. Mol Pharm. 2015. PMID: 25714793
The rapid decline of total paclitaxel concentration following intravenous administration of nab-paclitaxel and Cremophor EL-paclitaxel was attributed to rapid tissue distribution of the paclitaxel-carrier complexes, with minor contribution of free and protein-bound …
The rapid decline of total paclitaxel concentration following intravenous administration of nab-paclitaxel and Cremophor EL-paclitaxel was a …
Layer-by-layer assembly of hierarchical nanoarchitectures to enhance the systemic performance of nanoparticle albumin-bound paclitaxel.
Ruttala HB, Ramasamy T, Shin BS, Choi HG, Yong CS, Kim JO. Ruttala HB, et al. Int J Pharm. 2017 Mar 15;519(1-2):11-21. doi: 10.1016/j.ijpharm.2017.01.011. Epub 2017 Jan 6. Int J Pharm. 2017. PMID: 28069389
Although protein-bound paclitaxel (PTX, Abraxane()) has been established as a standard PTX-based therapy against multiple cancers, its clinical success is limited by unfavorable pharmacokinetics, suboptimal biodistribution, and acute toxicities. ...
Although protein-bound paclitaxel (PTX, Abraxane()) has been established as a standard PTX-based therapy against multip …
Perforation of gastric metastasis during chemotherapy with ramucirumab.
Kobashi M, Kanzaki H, Okada H. Kobashi M, et al. Curr Probl Cancer. 2021 Apr;45(2):100666. doi: 10.1016/j.currproblcancer.2020.100666. Epub 2020 Oct 22. Curr Probl Cancer. 2021. PMID: 33129565
A 59-year-old man received fifth line chemotherapy with ramucirumab and protein-bound paclitaxel for gastric metastasis from esophagogastric junction cancer. ...
A 59-year-old man received fifth line chemotherapy with ramucirumab and protein-bound paclitaxel for gastric metastasis …
Ultra-sensitive assay for paclitaxel in intracellular compartments of A549 cells using liquid chromatography-tandem mass spectrometry.
Wang T, Ma W, Sun Y, Yang Y, Zhang W, Fawcett JP, Du H, Gu J. Wang T, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jan 1;912:93-7. doi: 10.1016/j.jchromb.2012.10.033. Epub 2012 Nov 2. J Chromatogr B Analyt Technol Biomed Life Sci. 2013. PMID: 23262197
A549 cancer cells (10(6)) were incubated with paclitaxel (2ng/mL) for up to 4h and then subjected to sequential extraction of cytosolic, membrane/organelle, nuclear and cytoskeleton soluble protein. Fractions were ultrasonicated to release protein bound paclitaxe …
A549 cancer cells (10(6)) were incubated with paclitaxel (2ng/mL) for up to 4h and then subjected to sequential extraction of cytosolic, mem …
12 results