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Page 1
From purines to purinergic signalling: molecular functions and human diseases.
Huang Z, Xie N, Illes P, Di Virgilio F, Ulrich H, Semyanov A, Verkhratsky A, Sperlagh B, Yu SG, Huang C, Tang Y. Huang Z, et al. Signal Transduct Target Ther. 2021 Apr 28;6(1):162. doi: 10.1038/s41392-021-00553-z. Signal Transduct Target Ther. 2021. PMID: 33907179 Free PMC article. Review.
Purines act as endogenous ligands that bind to and activate plasmalemmal purinoceptors, which mediate extracellular communication referred to as "purinergic signalling". Purinergic signalling is cross-linked with other transmitter networks to coordinat …
Purines act as endogenous ligands that bind to and activate plasmalemmal purinoceptors, which mediate extracellular communication referred t …
Purinergic Signalling in the Cochlea.
Vlajkovic SM, Thorne PR. Vlajkovic SM, et al. Int J Mol Sci. 2022 Nov 28;23(23):14874. doi: 10.3390/ijms232314874. Int J Mol Sci. 2022. PMID: 36499200 Free PMC article. Review.
Purinergic signalling in cancer therapeutic resistance: From mechanisms to targeting strategies.
Jia W, Huang Z, Zhou L, Liou YC, Di Virgilio F, Ulrich H, Illes P, Zhang W, Huang C, Tang Y. Jia W, et al. Drug Resist Updat. 2023 Sep;70:100988. doi: 10.1016/j.drup.2023.100988. Epub 2023 Jun 28. Drug Resist Updat. 2023. PMID: 37413937 Free article. Review.
Purinergic signalling, consisting of extracellular purines and purinergic receptors, modulates cell proliferation, invasion and immunological reaction during cancer progression. ...Moreover, nano-based delivery technologies significantly improve the efficacy of agen …
Purinergic signalling, consisting of extracellular purines and purinergic receptors, modulates cell proliferation, invasion an …
Purinergic signalling in graft-versus-host disease.
Sluyter R, Cuthbertson P, Elhage A, Sligar C, Watson D. Sluyter R, et al. Curr Opin Pharmacol. 2023 Feb;68:102346. doi: 10.1016/j.coph.2022.102346. Epub 2023 Jan 10. Curr Opin Pharmacol. 2023. PMID: 36634595 Review.
GVHD is an inflammatory disorder mediated by donor leukocytes that damage host tissues. Purinergic signalling plays important roles in GVHD development in mice but studies of these pathways in human GVHD remain limited. ...In contrast, A(2A) receptor activation by a …
GVHD is an inflammatory disorder mediated by donor leukocytes that damage host tissues. Purinergic signalling plays important …
Purinergic signalling in spinal pain processing.
Tam TH, Salter MW. Tam TH, et al. Purinergic Signal. 2021 Mar;17(1):49-54. doi: 10.1007/s11302-020-09748-5. Epub 2020 Nov 10. Purinergic Signal. 2021. PMID: 33169292 Free PMC article. Review.
Purinergic signalling plays important roles in somatosensory and nociceptive transmission in the dorsal horn of the spinal cord under physiological and pathophysiological conditions. ...There is evidence that involvement of such P2X4 receptors is sexually dimorphic, …
Purinergic signalling plays important roles in somatosensory and nociceptive transmission in the dorsal horn of the spinal cor …
Purinergic Signalling: Therapeutic Developments.
Burnstock G. Burnstock G. Front Pharmacol. 2017 Sep 25;8:661. doi: 10.3389/fphar.2017.00661. eCollection 2017. Front Pharmacol. 2017. PMID: 28993732 Free PMC article. Review.
Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. ...Early studies were largely concerned with the physiology, pharmacology and biochemistry of purinergic signalling. More recently, the fo …
Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. ...Early stu …
Purinergic signalling and brain development.
Rodrigues RJ, Marques JM, Cunha RA. Rodrigues RJ, et al. Semin Cell Dev Biol. 2019 Nov;95:34-41. doi: 10.1016/j.semcdb.2018.12.001. Epub 2018 Dec 7. Semin Cell Dev Biol. 2019. PMID: 30529149 Review.
Accordingly, emerging evidence supports multiple roles for purinergic signalling in the control of different processes of brain development, such as embryonic neurogenesis, migration of principal neurons and interneurons, guidance for neuronal connectivity, synaptog …
Accordingly, emerging evidence supports multiple roles for purinergic signalling in the control of different processes of brai …
Interplay between purinergic signalling and extracellular vesicles in health and disease.
Carotti V, Rigalli JP, van Asbeck-van der Wijst J, Hoenderop JGJ. Carotti V, et al. Biochem Pharmacol. 2022 Sep;203:115192. doi: 10.1016/j.bcp.2022.115192. Epub 2022 Jul 26. Biochem Pharmacol. 2022. PMID: 35905971 Review.
Purinergic signalling has been related to the regulation of important physiological processes (e.g., renal electrolyte reabsorption; platelet aggregation; immune response). ...Within their cargo, EVs contain molecules with the potential to affect purinergic …
Purinergic signalling has been related to the regulation of important physiological processes (e.g., renal electrolyte reabsor …
1,524 results