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Year Number of Results
1984 5
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1987 2
1994 1
1995 1
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1999 3
2000 3
2003 2
2004 1
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2017 1
2024 0

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28 results

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Page 1
Targeting tumor cells based on Phosphodiesterase 3A expression.
Nazir M, Senkowski W, Nyberg F, Blom K, Edqvist PH, Jarvius M, Andersson C, Gustafsson MG, Nygren P, Larsson R, Fryknäs M. Nazir M, et al. Exp Cell Res. 2017 Dec 15;361(2):308-315. doi: 10.1016/j.yexcr.2017.10.032. Epub 2017 Oct 26. Exp Cell Res. 2017. PMID: 29107068
Cell lines with high PDE3A expression showed marked in vitro sensitivity to PDE inhibitors zardaverine and quazinone, when compared with those having low PDE3A expression. Immunofluorescence and immunohistochemical stainings were in agreement with PDE3A mRNA expression, pr …
Cell lines with high PDE3A expression showed marked in vitro sensitivity to PDE inhibitors zardaverine and quazinone, when compared w …
Modulation of neurotransmitter release by carbon monoxide at the frog neuro-muscular junction.
Sitdikova GF, Islamov RR, Mukhamedyarov MA, Permyakova VV, Zefirov AL, Palotás A. Sitdikova GF, et al. Curr Drug Metab. 2007 Feb;8(2):177-84. doi: 10.2174/138920007779815940. Curr Drug Metab. 2007. PMID: 17305496
Application of cGMP-activated phosphodiesterase-2 inhibitor EHNA did not prevent CO action, whereas inhibition of cGMP-inhibited phosphodiesterase-3 by quazinone has partially blocked the effect of CO. Utilizing immuno-histochemical methods CO-producing enzyme heme-oxygena …
Application of cGMP-activated phosphodiesterase-2 inhibitor EHNA did not prevent CO action, whereas inhibition of cGMP-inhibited phosphodies …
Mechanism of SNAP potentiating antiproliferative effect of calcitonin gene-related peptide in cultured vascular smooth muscle cells.
Wang X, Wang W, Li Y, Bai Y, Fiscus RR. Wang X, et al. J Mol Cell Cardiol. 1999 Sep;31(9):1599-606. doi: 10.1006/jmcc.1999.0991. J Mol Cell Cardiol. 1999. PMID: 10471344
SNAP (30 microm) and hCGRP (10-100 n m) or forskolin (10 microm), an activator of adenylate cyclase, caused more than additive cAMP elevations, but not cGMP elevations, in these cells. Quazinone, an inhibitor of cGMP-inhibited-phosphodiesterase (cGI-PDE, PDE3), or SNAP plu …
SNAP (30 microm) and hCGRP (10-100 n m) or forskolin (10 microm), an activator of adenylate cyclase, caused more than additive cAMP elevatio …
Effects of mitogen-activated protein kinase inhibitors or phosphodiesterase inhibitors on interleukin-1-induced cytokines production in synovium-derived cells.
Tsuji F, Oki K, Senda T, Horiuchi M, Mita S. Tsuji F, et al. Immunol Lett. 1999 Jun 1;68(2-3):275-9. doi: 10.1016/s0165-2478(99)00051-6. Immunol Lett. 1999. PMID: 10424432
However, many of its effects were weaker than those of SB202190 or SB203580. Quazinone, an inhibitor of cyclic GMP-inhibited PDE, scarcely affected cytokines production in both cells. ...
However, many of its effects were weaker than those of SB202190 or SB203580. Quazinone, an inhibitor of cyclic GMP-inhibited PDE, sca …
Phosphodiesterase 4-dependent regulation of cyclic AMP levels and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes.
Denis D, Riendeau D. Denis D, et al. Eur J Pharmacol. 1999 Feb 19;367(2-3):343-50. doi: 10.1016/s0014-2999(98)00987-x. Eur J Pharmacol. 1999. PMID: 10079010
Inhibitors of the phosphodiesterase 1 (8-methoxymethyl-1-methyl-3-(2-methylpropyl)xanthine (8-MeOMe-IBMX)), phosphodiesterase 2 (erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA)), phosphodiesterase 3 (quazinone and milrinone) and phosphodiesterase 5 (zaprinast and dipyridamole) …
Inhibitors of the phosphodiesterase 1 (8-methoxymethyl-1-methyl-3-(2-methylpropyl)xanthine (8-MeOMe-IBMX)), phosphodiesterase 2 (erythro-9-( …
Phosphodiesterase isoenzymes in human ureteral smooth muscle: identification, characterization, and functional effects of various phosphodiesterase inhibitors in vitro.
Stief CG, Taher A, Truss M, Becker AJ, Schulz-Knappe P, Meyer M, Uckert S, Forssmann WG, Jonas U. Stief CG, et al. Urol Int. 1995;55(4):183-9. doi: 10.1159/000282783. Urol Int. 1995. PMID: 8588263
All PDE inhibitors relaxed the strips dose-dependently with an EC50 of 30 microM for papaverine, 40 microM for zaprinast, 25 microM for quazinone, and 0.1 microM for rolipram. The existence of three different PDE isoenzymes was shown in this study. ...
All PDE inhibitors relaxed the strips dose-dependently with an EC50 of 30 microM for papaverine, 40 microM for zaprinast, 25 microM for q …
Differential effects of phosphodiesterase inhibitors on platelet activating factor (PAF)- and adenosine diphosphate (ADP)-induced equine platelet aggregation.
Rickards KJ, Andrews MJ, Waterworth TH, Alexander GB, Cunningham FM. Rickards KJ, et al. J Vet Pharmacol Ther. 2003 Aug;26(4):277-82. doi: 10.1046/j.1365-2885.2003.00486.x. J Vet Pharmacol Ther. 2003. PMID: 12887610
Cyclic AMP is broken down by phosphodiesterase (PDE) and, in the present study, the effects of theophylline, a nonselective PDE inhibitor, and selective inhibitors of PDE isoenzymes PDE3, PDE4 and PDE5, on equine platelet aggregation in response to platelet activating factor (PAF …
Cyclic AMP is broken down by phosphodiesterase (PDE) and, in the present study, the effects of theophylline, a nonselective PDE inhibitor, a …
Adrenomedullin induces direct (endothelium-independent) vasorelaxations and cyclic adenosine monophosphate elevations that are synergistically enhanced by brain natriuretic peptide in isolated rings of rat thoracic aorta.
Fung E, Fiscus RR. Fung E, et al. J Cardiovasc Pharmacol. 2003 Jun;41(6):849-55. doi: 10.1097/00005344-200306000-00004. J Cardiovasc Pharmacol. 2003. PMID: 12775961

ADM (100 nM) significantly (P < 0.05) increased cyclic adenosine monophosphate (cAMP) levels in denuded aortic rings pretreated with BNP (1 nM), but not in denuded rings without BNP. Quazinone (20 microM), a PDE3 inhibitor, caused similar enhancement of direct cAMP elev

…

ADM (100 nM) significantly (P < 0.05) increased cyclic adenosine monophosphate (cAMP) levels in denuded aortic rings pretreated with BNP

…
Allergen challenge alters lymphocyte phosphodiesterase activity in horses with heaves.
Rickards KJ, Page CP, Cunningham FM. Rickards KJ, et al. Pulm Pharmacol Ther. 2004;17(3):163-72. doi: 10.1016/j.pupt.2004.02.001. Pulm Pharmacol Ther. 2004. PMID: 15123226
Allergen challenge had no effect on either total cAMP PDE activity or its inhibition by the PDE4 selective inhibitor, rolipram, and the non-selective PDE inhibitor, theophylline. In contrast, the PDE3 selective inhibitor, quazinone, caused significantly greater inhibition …
Allergen challenge had no effect on either total cAMP PDE activity or its inhibition by the PDE4 selective inhibitor, rolipram, and the non- …
28 results