Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 2
1993 4
1994 5
1995 3
1996 2
1997 4
1998 2
1999 2
2000 4
2001 3
2002 2
2003 1
2005 4
2006 1
2007 2
2008 5
2009 5
2010 7
2011 6
2012 2
2013 4
2014 3
2015 3
2017 2
2018 2
2019 3
2020 1
2021 5
2022 6
2023 2
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

91 results

Results by year

Filters applied: . Clear all
Quoted phrase not found in phrase index: "RARA Gene Translocation"
Page 1
Acute promyelocytic leukemia current treatment algorithms.
Yilmaz M, Kantarjian H, Ravandi F. Yilmaz M, et al. Blood Cancer J. 2021 Jun 30;11(6):123. doi: 10.1038/s41408-021-00514-3. Blood Cancer J. 2021. PMID: 34193815 Free PMC article. Review.
APL, accounting for 10-15% of the newly diagnosed AML cases, results from a balanced translocation, t(15;17) (q22;q12-21), which leads to the fusion of the promyelocytic leukemia (PML) gene with the retinoic acid receptor alpha (RARA) gene. The PML- …
APL, accounting for 10-15% of the newly diagnosed AML cases, results from a balanced translocation, t(15;17) (q22;q12-21), which lead …
How retinoic acid and arsenic transformed acute promyelocytic leukemia therapy.
Korsos V, Miller WH Jr. Korsos V, et al. J Mol Endocrinol. 2022 Oct 11;69(4):T69-T83. doi: 10.1530/JME-22-0141. Print 2022 Nov 1. J Mol Endocrinol. 2022. PMID: 36112505 Review.
The definitive diagnosis of APL is made by identifying a balanced reciprocal translocation between chromosomes 15 and 17. This t(15;17) results in a fusion transcript of promyelocytic leukemia (PML) and retinoic acid receptor alpha (RARA) genes and the expres …
The definitive diagnosis of APL is made by identifying a balanced reciprocal translocation between chromosomes 15 and 17. This t(15;1 …
Mutational profile of ZBTB16-RARA-positive acute myeloid leukemia.
Fabiani E, Cicconi L, Nardozza AM, Cristiano A, Rossi M, Ottone T, Falconi G, Divona M, Testi AM, Annibali O, Castelli R, Lazarevic V, Rego E, Montesinos P, Esteve J, Venditti A, Della Porta M, Arcese W, Lo-Coco F, Voso MT. Fabiani E, et al. Cancer Med. 2021 Jun;10(12):3839-3847. doi: 10.1002/cam4.3904. Epub 2021 May 27. Cancer Med. 2021. PMID: 34042280 Free PMC article.
BACKGROUND: The ZBTB16-RARA fusion gene, resulting from the reciprocal translocation between ZBTB16 on chromosome 11 and RARA genes on chromosome 17 [t(11;17)(q23;q21)], is rarely observed in acute myeloid leukemia (AML), and accounts for about …
BACKGROUND: The ZBTB16-RARA fusion gene, resulting from the reciprocal translocation between ZBTB16 on chromosome 11 an …
Retinoids as Chemo-Preventive and Molecular-Targeted Anti-Cancer Therapies.
Hunsu VO, Facey COB, Fields JZ, Boman BM. Hunsu VO, et al. Int J Mol Sci. 2021 Jul 20;22(14):7731. doi: 10.3390/ijms22147731. Int J Mol Sci. 2021. PMID: 34299349 Free PMC article. Review.
For example, chromosomal translocation involving RARA occurs in acute promyelocytic leukemia (APL), and all-trans retinoic acid (ATRA) is a highly effective and even curative therapeutic for APL patients. ...We also deliberate on why retinoid agents have not shown …
For example, chromosomal translocation involving RARA occurs in acute promyelocytic leukemia (APL), and all-trans retinoic aci …
Molecular remission as a therapeutic objective in acute promyelocytic leukemia.
Cicconi L, Fenaux P, Kantarjian H, Tallman M, Sanz MA, Lo-Coco F. Cicconi L, et al. Leukemia. 2018 Aug;32(8):1671-1678. doi: 10.1038/s41375-018-0219-5. Epub 2018 Jul 19. Leukemia. 2018. PMID: 30026570 Review.
Acute promyelocytic leukemia (APL) is a subtype of acute leukemia characterized by a unique t(15;17) translocation generating the PML/RARA fusion gene and hybrid oncoprotein. ...Large clinical studies including two randomized trials conducted in …
Acute promyelocytic leukemia (APL) is a subtype of acute leukemia characterized by a unique t(15;17) translocation generating the PML …
RARA and PML genes in acute promyelocytic leukemia.
Chen Z, Chen SJ. Chen Z, et al. Leuk Lymphoma. 1992 Nov;8(4-5):253-60. doi: 10.3109/10428199209051004. Leuk Lymphoma. 1992. PMID: 1337847 Review.
The chromosome 17 breaks were mapped consistently within the second intron of the RARA gene while the chromosome 15 breaks were clustered in two limited regions within the PML gene. ...The RT/PCR procedure has been established to characterize the expression p …
The chromosome 17 breaks were mapped consistently within the second intron of the RARA gene while the chromosome 15 breaks wer …
Acute promyelocytic leukaemia and the t(15;17) translocation.
Gillard EF, Solomon E. Gillard EF, et al. Semin Cancer Biol. 1993 Dec;4(6):359-67. Semin Cancer Biol. 1993. PMID: 8142621 Review.
Acute promyelocytic leukaemia (APL) is a rare acute myeloid leukaemia characterized by a distinctive coagulopathy, the differentiation of promyelocytes in response to all-trans retinoic acid and a reciprocal chromosomal translocation, t(15;17)(q22;q12-q21). Molecular analy …
Acute promyelocytic leukaemia (APL) is a rare acute myeloid leukaemia characterized by a distinctive coagulopathy, the differentiation of pr …
Acute promyelocytic leukemia in childhood.
Gregory J, Feusner J. Gregory J, et al. Curr Oncol Rep. 2009 Nov;11(6):439-45. doi: 10.1007/s11912-009-0060-0. Curr Oncol Rep. 2009. PMID: 19840521 Review.
In the United States, APL in children constitutes only 5% to 10% of AML. Molecularly, the disease is characterized by a fusion protein, promyelocytic leukemia (PML)-retinoic acid receptor (RAR)-alpha that results from a balanced reciprocal translocation between the …
In the United States, APL in children constitutes only 5% to 10% of AML. Molecularly, the disease is characterized by a fusion protein …
Clinical and genomic characterization of an ATRA-insensitive acute promyelocytic leukemia variant with a FNDC3B::RARB fusion.
Kirkham JK, Liu YC, Foy SG, Ma J, Gheorghe G, Furtado LV, Popescu MI, Klco JM, Karol SE, Blackburn PR. Kirkham JK, et al. Genes Chromosomes Cancer. 2023 Oct;62(10):617-623. doi: 10.1002/gcc.23180. Epub 2023 Jun 7. Genes Chromosomes Cancer. 2023. PMID: 37283355
RARA and homologous receptors RARB and RARG are occasionally fused to other gene partners, which differentially affect sensitivity to targeted therapies. ...We present a 13-year-old male diagnosed with variant APL with a novel FNDC3B::RARB in-frame fusion that showe …
RARA and homologous receptors RARB and RARG are occasionally fused to other gene partners, which differentially affect sensiti …
Novel treatment of acute promyelocytic leukemia: As₂O₃, retinoic acid and retinoid pharmacology.
Zhu G. Zhu G. Curr Pharm Biotechnol. 2013;14(9):849-58. doi: 10.2174/1389201015666140113095812. Curr Pharm Biotechnol. 2013. PMID: 24433507 Review.
PML protein relocalizes into the wild-type nuclear body (PML-NB) configuration or/and wild-type RARa upregulated. ...Here, like v-erbA, PML/RARa is a (strong) transcriptional repressor of the RA receptor (RAR) complex, and PML/RARa fusion receptor g …
PML protein relocalizes into the wild-type nuclear body (PML-NB) configuration or/and wild-type RARa upregulated. ...Here, lik …
91 results