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Quoted phrase not found in phrase index: "RARA Gene Translocation"
Page 1
Acute promyelocytic leukemia current treatment algorithms.
Yilmaz M, Kantarjian H, Ravandi F. Yilmaz M, et al. Blood Cancer J. 2021 Jun 30;11(6):123. doi: 10.1038/s41408-021-00514-3. Blood Cancer J. 2021. PMID: 34193815 Free PMC article. Review.
APL, accounting for 10-15% of the newly diagnosed AML cases, results from a balanced translocation, t(15;17) (q22;q12-21), which leads to the fusion of the promyelocytic leukemia (PML) gene with the retinoic acid receptor alpha (RARA) gene. The PML- …
APL, accounting for 10-15% of the newly diagnosed AML cases, results from a balanced translocation, t(15;17) (q22;q12-21), which lead …
How retinoic acid and arsenic transformed acute promyelocytic leukemia therapy.
Korsos V, Miller WH Jr. Korsos V, et al. J Mol Endocrinol. 2022 Oct 11;69(4):T69-T83. doi: 10.1530/JME-22-0141. Print 2022 Nov 1. J Mol Endocrinol. 2022. PMID: 36112505 Review.
The definitive diagnosis of APL is made by identifying a balanced reciprocal translocation between chromosomes 15 and 17. This t(15;17) results in a fusion transcript of promyelocytic leukemia (PML) and retinoic acid receptor alpha (RARA) genes and the expres …
The definitive diagnosis of APL is made by identifying a balanced reciprocal translocation between chromosomes 15 and 17. This t(15;1 …
Mutational profile of ZBTB16-RARA-positive acute myeloid leukemia.
Fabiani E, Cicconi L, Nardozza AM, Cristiano A, Rossi M, Ottone T, Falconi G, Divona M, Testi AM, Annibali O, Castelli R, Lazarevic V, Rego E, Montesinos P, Esteve J, Venditti A, Della Porta M, Arcese W, Lo-Coco F, Voso MT. Fabiani E, et al. Cancer Med. 2021 Jun;10(12):3839-3847. doi: 10.1002/cam4.3904. Epub 2021 May 27. Cancer Med. 2021. PMID: 34042280 Free PMC article.
BACKGROUND: The ZBTB16-RARA fusion gene, resulting from the reciprocal translocation between ZBTB16 on chromosome 11 and RARA genes on chromosome 17 [t(11;17)(q23;q21)], is rarely observed in acute myeloid leukemia (AML), and accounts for about …
BACKGROUND: The ZBTB16-RARA fusion gene, resulting from the reciprocal translocation between ZBTB16 on chromosome 11 an …
Fusion genes in malignant neoplastic disorders of haematopoietic system.
Saleem M, Yusoff NM. Saleem M, et al. Hematology. 2016 Oct;21(9):501-12. doi: 10.1080/10245332.2015.1106816. Epub 2016 Feb 24. Hematology. 2016. PMID: 26871368 Review.
RESULTS AND DISCUSSION: Multiple translocation partner genes are well known for leukaemia such as MYC, MLL, RARA, ALK, and RUNX1. With the advent of more sophisticated diagnostic tools and bioinformatics algorithms, an exponential growth in fusion genes …
RESULTS AND DISCUSSION: Multiple translocation partner genes are well known for leukaemia such as MYC, MLL, RARA, ALK, …
Incidence of preleukemic fusion genes in healthy subjects.
Kosik P, Skorvaga M, Belyaev I. Kosik P, et al. Neoplasma. 2016;63(5):659-72. doi: 10.4149/neo_2016_502. Neoplasma. 2016. PMID: 27468869 Review.
Childhood leukemia is often determined by the presence of specific chromosomal translocation that entails the generation of preleukemic fusion genes (PFG). ...This review aims to highlight the molecular genetic approaches used by various studies with regard t …
Childhood leukemia is often determined by the presence of specific chromosomal translocation that entails the generation of preleukem …
Molecular remission as a therapeutic objective in acute promyelocytic leukemia.
Cicconi L, Fenaux P, Kantarjian H, Tallman M, Sanz MA, Lo-Coco F. Cicconi L, et al. Leukemia. 2018 Aug;32(8):1671-1678. doi: 10.1038/s41375-018-0219-5. Epub 2018 Jul 19. Leukemia. 2018. PMID: 30026570 Review.
Acute promyelocytic leukemia (APL) is a subtype of acute leukemia characterized by a unique t(15;17) translocation generating the PML/RARA fusion gene and hybrid oncoprotein. ...The results consistently showed that molecular remission (defined as negativizati …
Acute promyelocytic leukemia (APL) is a subtype of acute leukemia characterized by a unique t(15;17) translocation generating the PML …
Acute promyelocytic leukaemia and the t(15;17) translocation.
Gillard EF, Solomon E. Gillard EF, et al. Semin Cancer Biol. 1993 Dec;4(6):359-67. Semin Cancer Biol. 1993. PMID: 8142621 Review.
Acute promyelocytic leukaemia (APL) is a rare acute myeloid leukaemia characterized by a distinctive coagulopathy, the differentiation of promyelocytes in response to all-trans retinoic acid and a reciprocal chromosomal translocation, t(15;17)(q22;q12-q21). Molecular analy …
Acute promyelocytic leukaemia (APL) is a rare acute myeloid leukaemia characterized by a distinctive coagulopathy, the differentiation of pr …
Acute Myeloid Leukemia: Diagnosis and Management Based on Current Molecular Genetics Approach.
Suguna E, Farhana R, Kanimozhi E, Kumar PS, Kumaramanickavel G, Kumar CS. Suguna E, et al. Cardiovasc Hematol Disord Drug Targets. 2018;18(3):199-207. doi: 10.2174/1871529X18666180515130136. Cardiovasc Hematol Disord Drug Targets. 2018. PMID: 29766829 Review.
For better clinical management, cytogenetic finding in AML is necessary and in patients with normal karyotypes - molecular, epigenetic and proteomic biomarkers are very important in choosing which drugs to prescribe. Mutations of certain genes like NPM1, FLT3, CEBPA, RUNX1 …
For better clinical management, cytogenetic finding in AML is necessary and in patients with normal karyotypes - molecular, epigenetic and p …
Pathogenesis, diagnosis and monitoring of residual disease in acute promyelocytic leukaemia.
Reiter A, Lengfelder E, Grimwade D. Reiter A, et al. Acta Haematol. 2004;112(1-2):55-67. doi: 10.1159/000077560. Acta Haematol. 2004. PMID: 15179005 Review.
APL is characterized by chromosomal rearrangements of 17q21 leading to the formation of fusion proteins involving retinoic acid receptor alpha (RARA). To date five different fusion partners of RARA have been identified, but the vast majority of cases are characteriz …
APL is characterized by chromosomal rearrangements of 17q21 leading to the formation of fusion proteins involving retinoic acid receptor alp …
Variant and masked translocations in acute promyelocytic leukemia.
Brunel V, Lafage-Pochitaloff M, Alcalay M, Pelicci PG, Birg F. Brunel V, et al. Leuk Lymphoma. 1996 Jul;22(3-4):221-8. doi: 10.3109/10428199609051752. Leuk Lymphoma. 1996. PMID: 8819070 Review.
Rearrangements of RARA and PML were documented in some of these variant translocations. In contrast, recent molecular analysis of APL cases with cytogenetically normal chromosomes 15 and 17 revealed the occurrence of submicroscopic translocations, leading to …
Rearrangements of RARA and PML were documented in some of these variant translocations. In contrast, recent molecular analysis …
138 results