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Quoted phrase not found in phrase index: "RNF43 Protein Variant"
Page 1
RNF43 pathogenic Germline variant in a family with colorectal cancer.
Mikaeel RR, Young JP, Li Y, Poplawski NK, Smith E, Horsnell M, Uylaki W, Tomita Y, Townsend AR, Feng J, Zibat A, Kaulfuß S, Müller C, Yigit G, Wollnik B, Scott H, Rawlings L, Henry D, Vakulin C, Dubowsky A, Price TJ. Mikaeel RR, et al. Clin Genet. 2022 Jan;101(1):122-126. doi: 10.1111/cge.14064. Epub 2021 Sep 27. Clin Genet. 2022. PMID: 34541672
This report presents our findings of two individuals with CRC from a single family carrying a likely-pathogenic inherited germline variant in RNF43. The proband (III:1) and the proband's mother (II:2) were diagnosed with mismatch repair proficient CRCs at the age of …
This report presents our findings of two individuals with CRC from a single family carrying a likely-pathogenic inherited germline varian …
Treatment of BRAF-V600E mutant metastatic colorectal cancer: new insights and biomarkers.
Ros J, Rodríguez-Castells M, Saoudi N, Baraibar I, Salva F, Tabernero J, Élez E. Ros J, et al. Expert Rev Anticancer Ther. 2023 Jul-Dec;23(8):797-806. doi: 10.1080/14737140.2023.2236794. Epub 2023 Jul 23. Expert Rev Anticancer Ther. 2023. PMID: 37482749 Review.
AREAS COVERED: The development of targeted therapy for BRAF-V600E mCRC starting with BRAF inhibitors as monotherapy through novel combinations with anti-VEGF or anti-PD1 agents to enhance antitumor activity is reviewed, with a particular focus on the development of predictive …
AREAS COVERED: The development of targeted therapy for BRAF-V600E mCRC starting with BRAF inhibitors as monotherapy through novel combinatio …
Association of RNF43 Genetic Alterations With BRAF(V600E) and MSI(high) in Colorectal Cancer.
Vogel A, Murugesan K, Kendre G, Quintanilha JCF, Ross JS, Brummer T, Saborowski A. Vogel A, et al. JCO Precis Oncol. 2024 Feb;8:e2300411. doi: 10.1200/PO.23.00411. JCO Precis Oncol. 2024. PMID: 38394466
PURPOSE: Recent studies have provided evidence for a predictive value of RNF43 genetic alterations (GAs) as biomarkers for targeted therapies in microsatellite-stable (MSS) colorectal cancer (CRC). ...CONCLUSION: Ongoing phase III clinical trials, such as BREAKWATER …
PURPOSE: Recent studies have provided evidence for a predictive value of RNF43 genetic alterations (GAs) as biomarkers for tar …
eVIP2: Expression-based variant impact phenotyping to predict the function of gene variants.
Thornton AM, Fang L, Lo A, McSharry M, Haan D, O'Brien C, Berger AH, Giannakis M, Brooks AN. Thornton AM, et al. PLoS Comput Biol. 2021 Jul 2;17(7):e1009132. doi: 10.1371/journal.pcbi.1009132. eCollection 2021 Jul. PLoS Comput Biol. 2021. PMID: 34214079 Free PMC article.
RNF43 WT, RNF43 R117fs, RNF43 G659fs, or GFP control cDNA were overexpressed in HEK293T cells. ...Additional eVIP Pathways analysis of RNF43 G659fs predicted 10 pathways to be significantly altered, including TNF-alpha via NFkappaB signaling, KR …
RNF43 WT, RNF43 R117fs, RNF43 G659fs, or GFP control cDNA were overexpressed in HEK293T cells. ...Additional eVIP Pathw …
Multiomic Characterization Reveals a Distinct Molecular Landscape in Young-Onset Pancreatic Cancer.
Ogobuiro I, Baca Y, Ribeiro JR, Walker P, Wilson GC, Gulhati P, Marshall JL, Shroff RT, Spetzler D, Oberley MJ, Abbott DE, Kim HJ, Kooby DA, Maithel SK, Ahmad SA, Merchant NB, Xiu J, Hosein PJ, Datta J. Ogobuiro I, et al. JCO Precis Oncol. 2023 Sep;7:e2300152. doi: 10.1200/PO.23.00152. JCO Precis Oncol. 2023. PMID: 37944072 Free PMC article.
RESULTS: Patients with YOPC had higher proportions of mismatch repair-deficient/microsatellite instability-high, BRCA2-mutant, and PALB2-mutant tumors compared with patients with AOPC, but fewer SMAD4-, RNF43-, CDKN2A-, and SF3B1-mutant tumors. ...Ther …
RESULTS: Patients with YOPC had higher proportions of mismatch repair-deficient/microsatellite instability-high, BRCA2-mutant, and PA …
The Functional Landscape of Patient-Derived RNF43 Mutations Predicts Sensitivity to Wnt Inhibition.
Yu J, Yusoff PAM, Woutersen DTJ, Goh P, Harmston N, Smits R, Epstein DM, Virshup DM, Madan B. Yu J, et al. Cancer Res. 2020 Dec 15;80(24):5619-5632. doi: 10.1158/0008-5472.CAN-20-0957. Epub 2020 Oct 16. Cancer Res. 2020. PMID: 33067269
However, it is not clear which of the clinically identified RNF43 mutations affect its function in vivo. We assayed 119 missense and 45 truncating RNF43 mutations found in human cancers using a combination of cell-based reporter assays, genome editing, flow cytometr …
However, it is not clear which of the clinically identified RNF43 mutations affect its function in vivo. We assayed 119 missense and …
Genomic landscape and its prognostic significance in stage III colorectal cancer: JCOG1506A1, an ancillary of JCOG0910.
Shida D, Kuchiba A, Shibata T, Hamaguchi T, Yamasaki S, Ito M, Kobatake T, Tonooka T, Masaki T, Shiozawa M, Takii Y, Uetake H, Okamura S, Ojima H, Kazama S, Takeyama H, Kanato K, Shimada Y, Murakami Y, Kanemitsu Y. Shida D, et al. Cancer Sci. 2023 Aug;114(8):3352-3363. doi: 10.1111/cas.15834. Epub 2023 May 15. Cancer Sci. 2023. PMID: 37189003 Free PMC article.
Differences by stage and ethnicity in the genomic landscape and their prognostic impact remain poorly understood. We investigated 534 Japanese stage III colorectal cancer samples from the Phase III trial, JCOG0910. ...Modest associations were observed: poorer relapse-free …
Differences by stage and ethnicity in the genomic landscape and their prognostic impact remain poorly understood. We investigated 534 …
BRAF V600E and RNF43 Co-mutations Predict Patient Outcomes With Targeted Therapies in Real-World Cases of Colorectal Cancer.
Quintanilha JCF, Graf RP, Oxnard GR. Quintanilha JCF, et al. Oncologist. 2023 Mar 17;28(3):e171-e174. doi: 10.1093/oncolo/oyac265. Oncologist. 2023. PMID: 36779536 Free PMC article.
No difference in outcomes was observed between patient groups with RNF43-mutant versus wild-type receiving standard-of-care chemotherapy. BRAFV600E/RNF43 co-mutations predict mCRC anti-BRAF/EGFR outcomes in diverse clinical settings....
No difference in outcomes was observed between patient groups with RNF43-mutant versus wild-type receiving standard-of-care ch …
Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma.
Jiang X, Hao HX, Growney JD, Woolfenden S, Bottiglio C, Ng N, Lu B, Hsieh MH, Bagdasarian L, Meyer R, Smith TR, Avello M, Charlat O, Xie Y, Porter JA, Pan S, Liu J, McLaughlin ME, Cong F. Jiang X, et al. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12649-54. doi: 10.1073/pnas.1307218110. Epub 2013 Jul 11. Proc Natl Acad Sci U S A. 2013. PMID: 23847203 Free PMC article.
Strikingly, all LGK974-sensitive lines carried inactivating mutations of RNF43. Inhibition of Wnt secretion, depletion of beta-catenin, or expression of wild-type RNF43 blocked proliferation of RNF43 mutant but not RNF43-wild-type pancreatic can …
Strikingly, all LGK974-sensitive lines carried inactivating mutations of RNF43. Inhibition of Wnt secretion, depletion of beta-cateni …
Wild-type APC Is Associated with Poor Survival in Metastatic Microsatellite Stable Colorectal Cancer.
Wang C, Ouyang C, Cho M, Ji J, Sandhu J, Goel A, Kahn M, Fakih M. Wang C, et al. Oncologist. 2021 Mar;26(3):208-214. doi: 10.1002/onco.13607. Epub 2020 Dec 7. Oncologist. 2021. PMID: 33230914 Free PMC article.
BACKGROUND: The prognostic implication of wild-type APC (APC-WT) in microsatellite stable (MSS) metastatic colorectal cancer (mCRC) is not well defined. ...Alternative WNT pathway alterations, RNF43 and CTNNB1, were over-represented in the APC-WT versus APC-MT popul …
BACKGROUND: The prognostic implication of wild-type APC (APC-WT) in microsatellite stable (MSS) metastatic colorectal cancer (mCRC) i …
11 results