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Quoted phrase not found in phrase index: "Rearrangement of 3q"
Page 1
Two effects of GATA2 enhancer repositioning by 3q chromosomal rearrangements.
Suzuki M, Katayama S, Yamamoto M. Suzuki M, et al. IUBMB Life. 2020 Jan;72(1):159-169. doi: 10.1002/iub.2191. Epub 2019 Dec 9. IUBMB Life. 2020. PMID: 31820561 Free article. Review.
Chromosomal inversion and translocation between 3q21 and 3q26 [inv (3)(q21.3q26.2) and t(3;3)(q21.3;q26.2), respectively] give rise to acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), which have poor prognoses. The chromosomal rearrangements repositi …
Chromosomal inversion and translocation between 3q21 and 3q26 [inv (3)(q21.3q26.2) and t(3;3)(q21.3;q26.2), respectively] give rise to acute …
The complex landscape of genetic alterations in mantle cell lymphoma.
Royo C, Salaverria I, Hartmann EM, Rosenwald A, Campo E, Beà S. Royo C, et al. Semin Cancer Biol. 2011 Nov;21(5):322-34. doi: 10.1016/j.semcancer.2011.09.007. Epub 2011 Sep 18. Semin Cancer Biol. 2011. PMID: 21945515 Review.
Small subsets of cases have been identified with variant CCND1 translocations with the immunoglobulin light chain genes or with alternative translocations involving CCND2 and CCND3. Additionally, double-hit MCL with MYC rearrangements with a highly aggressive clinical c …
Small subsets of cases have been identified with variant CCND1 translocations with the immunoglobulin light chain genes or with alternative …
Review: Aberrant EVI1 expression in acute myeloid leukaemia.
Hinai AA, Valk PJ. Hinai AA, et al. Br J Haematol. 2016 Mar;172(6):870-8. doi: 10.1111/bjh.13898. Epub 2016 Jan 5. Br J Haematol. 2016. PMID: 26729571 Free article. Review.
However, EVI1 overexpression has been revealed as an important independent adverse prognostic marker in adult AML and defines distinct risk categories in 11q23-rearranged AML. Recently, important progress has been made in the delineation of the mechanism by which EV …
However, EVI1 overexpression has been revealed as an important independent adverse prognostic marker in adult AML and defines distinc …
Acute leukemia with structural rearrangements of chromosome 3.
Horsman DE, Gascoyne RD, Barnett MJ. Horsman DE, et al. Leuk Lymphoma. 1995 Feb;16(5-6):369-77. doi: 10.3109/10428199509054422. Leuk Lymphoma. 1995. PMID: 7787746 Review.
Cytogenetic investigations have distinguished at least 3 distinct clinical-cytogenetic syndromes of hematopoietic malignancy with structural rearrangement of 3q. The majority of cases have breakpoints at both 3q21 and 3q26, frequently associated with monosomy 7, abnormal t …
Cytogenetic investigations have distinguished at least 3 distinct clinical-cytogenetic syndromes of hematopoietic malignancy with structural …
Rearrangements of chromosome band 3q21 in myeloid leukemia.
Wieser R. Wieser R. Leuk Lymphoma. 2002 Jan;43(1):59-65. doi: 10.1080/10428190210196. Leuk Lymphoma. 2002. PMID: 11908737 Review.
Chromosome rearrangements affecting band 3q21, namely, the inv(3)(q21q26), the t(3;3)(q21;q26), and the t(1;3)(p36;q21), are associated with a particularly poor prognosis in myeloid leukemia or myelodysplasia. ...Activation of the EVI-1 gene in 3q26 by regula …
Chromosome rearrangements affecting band 3q21, namely, the inv(3)(q21q26), the t(3;3)(q21;q26), and the t(1;3)(p36;q21), are associat …
Atypical 3q26/MECOM rearrangements genocopy inv(3)/t(3;3) in acute myeloid leukemia.
Ottema S, Mulet-Lazaro R, Beverloo HB, Erpelinck C, van Herk S, van der Helm R, Havermans M, Grob T, Valk PJM, Bindels E, Haferlach T, Haferlach C, Smeenk L, Delwel R. Ottema S, et al. Blood. 2020 Jul 9;136(2):224-234. doi: 10.1182/blood.2019003701. Blood. 2020. PMID: 32219447 Free article.
The full-length MECOM transcript, MDS1-EVI1, is not expressed as the result of the 3q26 rearrangement. Besides the classical inv(3)/t(3;3), a number of other 3q26/MECOM rearrangements with poor treatment response have been reported in AML. ...Therefore, we conclude …
The full-length MECOM transcript, MDS1-EVI1, is not expressed as the result of the 3q26 rearrangement. Besides the classical inv(3)/t …
Genomic imbalances in human leukemia and lymphoma detected by comparative genomic hybridization (Review).
Gebhart E. Gebhart E. Int J Oncol. 2005 Sep;27(3):593-606. Int J Oncol. 2005. PMID: 16077907 Review.
The obtained data shed light on genomic alterations beyond the basic rearrangements known as 'causative aberrations' in many of these diseases. ...With respect to their clinical significance, the presence of genomic imbalances is associated with disease progression and, th …
The obtained data shed light on genomic alterations beyond the basic rearrangements known as 'causative aberrations' in many of these …
The value of molecular genetic analysis in the diagnosis and prognosis of renal cell tumours.
Kovacs G. Kovacs G. World J Urol. 1994;12(2):64-8. doi: 10.1007/BF00184238. World J Urol. 1994. PMID: 8087142 Review.
Chromophobe renal cell carcinomas are marked by a highly specific combination of loss of chromosomes 1, 2, 6, 10, 13, 17 and 21 and gross rearrangement of mitochondrial DNA. Subsets of renal oncocytomas show minimal karyotype alterations or translocation 11q13;? ...There a …
Chromophobe renal cell carcinomas are marked by a highly specific combination of loss of chromosomes 1, 2, 6, 10, 13, 17 and 21 and gross …
Incidence and prognostic impact of secondary cytogenetic aberrations in a series of 145 patients with mantle cell lymphoma.
Espinet B, Salaverria I, Beà S, Ruiz-Xivillé N, Balagué O, Salido M, Costa D, Carreras J, Rodríguez-Vicente AE, Luís García J, Hernández-Rivas JM, Calasanz MJ, Siebert R, Ferrer A, Salar A, Carrió A, Polo N, García-Marco JA, Domingo A, González-Barca E, Romagosa V, Marugán I, López-Guillermo A, Millá F, Luís Mate J, Luño E, Sanzo C, Collado R, Oliver I, Monzó S, Palacín A, González T, Sant F, Salinas R, Ardanaz MT, Font L, Escoda L, Florensa L, Serrano S, Campo E, Solé F. Espinet B, et al. Genes Chromosomes Cancer. 2010 May;49(5):439-51. doi: 10.1002/gcc.20754. Genes Chromosomes Cancer. 2010. PMID: 20143418
Gains of 3q and 13q and 17p13 losses were associated with reduced survival times. Interestingly, gains of 3q and 17p losses added prognostic significance to the morphology in a multivariate analysis. Our findings confirm previous observations indicating that proliferation …
Gains of 3q and 13q and 17p13 losses were associated with reduced survival times. Interestingly, gains of 3q and 17p losses added prognos …
Retrospective evaluation of the clinical and laboratory data from 300 patients of various hematological malignancies with chromosome 3 abnormalities.
Liu D, Zhang Y, Chen S, Pan J, He X, Liang J, Chen Z. Liu D, et al. Cancer Genet. 2015 Jun;208(6):333-40. doi: 10.1016/j.cancergen.2015.03.013. Epub 2015 Apr 9. Cancer Genet. 2015. PMID: 26032184
In this series, genomic losses were the most frequent genetic abnormalities in AML, ALL, and hybrid acute leukemia (HAL) patients, whereas structural rearrangements were frequently seen in chronic myeloid leukemia (CML) and MDS patients, and genomic gains in MM, lymphoma a …
In this series, genomic losses were the most frequent genetic abnormalities in AML, ALL, and hybrid acute leukemia (HAL) patients, whereas s …
45 results