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Quoted phrase not found in phrase index: "Reduced bone-marrow megakaryocyte size"
Page 1
The control of megakaryocyte ploidy and platelet production: biology and pathology.
Gladwin AM, Martin JF. Gladwin AM, et al. Int J Cell Cloning. 1990 Jul;8(4):291-8. doi: 10.1002/stem.5530080414. Int J Cell Cloning. 1990. PMID: 2205666 Free article. Review.
Following experimental platelet destruction in animals, large platelets, which are more hemostatically active, are produced before any change in bone marrow megakaryocyte DNA content. When platelet production is stimulated by administration of i.v. vincristin …
Following experimental platelet destruction in animals, large platelets, which are more hemostatically active, are produced before any chang …
Peripheral and intrasplenic platelet kinetics and bone marrow megakaryopoiesis in alpha-2b-interferon treated hairy cell leukemia.
Wadenvik H, Braide I, Ridell B, Kutti J, Jacobsson S, Revesz P. Wadenvik H, et al. Leuk Res. 1994 Aug;18(8):569-75. doi: 10.1016/0145-2126(94)90038-8. Leuk Res. 1994. PMID: 8065159
At the time when treatment was initiated, the patients were heterogeneous as regards the spleen size, platelet kinetics, and the bone marrow morphology. Three patients had values for P below the 95th percentile for a group of healthy control subjects; followi …
At the time when treatment was initiated, the patients were heterogeneous as regards the spleen size, platelet kinetics, and the b …
Deleterious mutation in the FYB gene is associated with congenital autosomal recessive small-platelet thrombocytopenia.
Levin C, Koren A, Pretorius E, Rosenberg N, Shenkman B, Hauschner H, Zalman L, Khayat M, Salama I, Elpeleg O, Shalev S. Levin C, et al. J Thromb Haemost. 2015 Jul;13(7):1285-92. doi: 10.1111/jth.12966. Epub 2015 May 25. J Thromb Haemost. 2015. PMID: 25876182 Free article.
Homozygosity mapping and exome sequencing were used to identify the genetic lesion causing the disease phenotype on chromosome 5. Bone-marrow morphology and platelet function were analyzed. Platelets were characterized by scanning electron microscopy. RESULTS: We id …
Homozygosity mapping and exome sequencing were used to identify the genetic lesion causing the disease phenotype on chromosome 5. Bone …
The role of alpha-interferon in essential thrombocythaemia, polycythaemia vera and myelofibrosis with myeloid metaplasia (MMM): a concise update.
Sacchi S. Sacchi S. Leuk Lymphoma. 1995 Sep;19(1-2):13-20. doi: 10.3109/10428199509059658. Leuk Lymphoma. 1995. PMID: 8574158 Review.
To date, there is no generally accepted treatment for these diseases which can reduce the risk of thromboembolism and/or haemorrhagic events, avoid any increase in the frequency of secondary myelofibrosis and terminal blast transformation and decrease the reticulin content …
To date, there is no generally accepted treatment for these diseases which can reduce the risk of thromboembolism and/or haemorrhagic …
Hypermucoviscous Klebsiella pneumoniae infections induce platelet aggregation and apoptosis and inhibit maturation of megakaryocytes.
Wang Z, Ren J, Liu Q, Li J, Wu X, Wang W, Wu J, Wang G, Li J. Wang Z, et al. Thromb Res. 2018 Nov;171:45-54. doi: 10.1016/j.thromres.2018.09.053. Epub 2018 Sep 20. Thromb Res. 2018. PMID: 30248660
Count, aggregation rate and apoptosis proportion of platelets within 12 h were examined. CD41 expression was measured in bone marrow cells to determine the maturation of megakaryocytes. ...All infections induced apoptosis of platelets, among which the highest …
Count, aggregation rate and apoptosis proportion of platelets within 12 h were examined. CD41 expression was measured in bone marr …
Distinct roles of the mTOR components Rictor and Raptor in MO7e megakaryocytic cells.
Fuhler GM, Tyl MR, Olthof SG, Lyndsay Drayer A, Blom N, Vellenga E. Fuhler GM, et al. Eur J Haematol. 2009 Sep;83(3):235-45. doi: 10.1111/j.1600-0609.2009.01263.x. Epub 2009 Apr 1. Eur J Haematol. 2009. PMID: 19341427
OBJECTIVE: During megakaryopoiesis, hematopoietic progenitor cells in the bone marrow proliferate and ultimately differentiate in mature megakaryocytes (MK). ...Knocking down Raptor expression resulted in a reduced expansion and a reduced cell …
OBJECTIVE: During megakaryopoiesis, hematopoietic progenitor cells in the bone marrow proliferate and ultimately differentiate …
Role of immunocompetent cells in the regulation of human megakaryocytopoiesis in vitro.
Detrick RA, Schulman JC, Mamus SW, McEver RP, Zanjani ED. Detrick RA, et al. Adv Exp Med Biol. 1988;241:199-215. doi: 10.1007/978-1-4684-5571-7_23. Adv Exp Med Biol. 1988. PMID: 3146906
The removal of T cells from BM (BM-T) caused a significant decrease (71.3 +/- 3.2 colonies observed vs 231.2 +/- 38.5 colonies predicted) in both the number and size of CFU-Mk derived colonies, and no such changes were seen with Mo depletion (BM-Mo); co-cultu …
The removal of T cells from BM (BM-T) caused a significant decrease (71.3 +/- 3.2 colonies observed vs 231.2 +/- 38.5 colonies pre …
Autosomal dominant thrombocytopenia: incomplete megakaryocyte differentiation and linkage to human chromosome 10.
Drachman JG, Jarvik GP, Mehaffey MG. Drachman JG, et al. Blood. 2000 Jul 1;96(1):118-25. Blood. 2000. PMID: 10891439 Free article.
Affected family members are characterized by lifelong moderate thrombocytopenia (mean = 42.7 x 10(9)/L) with moderate propensity toward easy bruising and minor bleeding. Megakaryocytes are present in bone marrow with reduced frequency, and there are no …
Affected family members are characterized by lifelong moderate thrombocytopenia (mean = 42.7 x 10(9)/L) with moderate propensity toward easy …
The effects of hematopoietic stem cell transplant on splenic extramedullary hematopoiesis in patients with myeloproliferative neoplasm-associated myelofibrosis.
Pizzi M, Gergis U, Chaviano F, Orazi A. Pizzi M, et al. Hematol Oncol Stem Cell Ther. 2016 Sep;9(3):96-104. doi: 10.1016/j.hemonc.2016.07.002. Epub 2016 Aug 6. Hematol Oncol Stem Cell Ther. 2016. PMID: 27521149 Free article.
This study compares the findings seen in spleens following HSCT with those of nontransplanted patients, normal controls, and matched bone marrow (BM) samples. METHODS: This study included three transplanted MPN-MF spleens, three nontransplanted MPN-MF spleens, and t …
This study compares the findings seen in spleens following HSCT with those of nontransplanted patients, normal controls, and matched bone …
The assessment of the hematopoietic reservoir after immunosuppressive therapy or bone marrow transplantation in severe aplastic anemia.
Podesta M, Piaggio G, Frassoni F, Pitto A, Zikos P, Sessarego M, Abate M, Teresa Van Lint M, Berisso G, Bacigalupo A. Podesta M, et al. Blood. 1998 Mar 15;91(6):1959-65. Blood. 1998. PMID: 9490678 Free article.
We investigated the hematopoietic reservoir in 43 severe aplastic anemia (SAA) patients following immunosuppression (IS) (n = 15) or bone marrow transplantation (BMT) (n = 28), at a median interval of 5 years (range, 2-20) from treatment. ...Burst forming unit-eryth …
We investigated the hematopoietic reservoir in 43 severe aplastic anemia (SAA) patients following immunosuppression (IS) (n = 15) or bone …
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