Complement activation in sickle cell disease: Dependence on cell density, hemolysis and modulation by hydroxyurea therapy.
Roumenina LT, Chadebech P, Bodivit G, Vieira-Martins P, Grunenwald A, Boudhabhay I, Poillerat V, Pakdaman S, Kiger L, Jouard A, Audureau E, Pirenne F, Galactéros F, Frémeaux-Bacchi V, Bartolucci P.
Roumenina LT, et al.
Am J Hematol. 2020 May;95(5):456-464. doi: 10.1002/ajh.25742. Epub 2020 Feb 19.
Am J Hematol. 2020.
PMID: 31990387
Free article.
We show that greater complement activation in vitro is promoted by SCD erythrocytes compared to normal ones, although no significant differences were observed in the regulatory proteins CD35, CD55, and CD59 in whole blood. Complement activation is positively correla …
We show that greater complement activation in vitro is promoted by SCD erythrocytes compared to normal ones, although no significant differe …