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Quoted phrase not found in phrase index: "Reduced T cell CD40 expression"
Page 1
Tim-4(+) cavity-resident macrophages impair anti-tumor CD8(+) T cell immunity.
Chow A, Schad S, Green MD, Hellmann MD, Allaj V, Ceglia N, Zago G, Shah NS, Sharma SK, Mattar M, Chan J, Rizvi H, Zhong H, Liu C, Bykov Y, Zamarin D, Shi H, Budhu S, Wohlhieter C, Uddin F, Gupta A, Khodos I, Waninger JJ, Qin A, Markowitz GJ, Mittal V, Balachandran V, Durham JN, Le DT, Zou W, Shah SP, McPherson A, Panageas K, Lewis JS, Perry JSA, de Stanchina E, Sen T, Poirier JT, Wolchok JD, Rudin CM, Merghoub T. Chow A, et al. Cancer Cell. 2021 Jul 12;39(7):973-988.e9. doi: 10.1016/j.ccell.2021.05.006. Epub 2021 Jun 10. Cancer Cell. 2021. PMID: 34115989 Free PMC article.
We show that metastatic disease in the pleural and peritoneal cavities is associated with poor clinical outcomes after ICB therapy. Cavity-resident macrophages express high levels of Tim-4, a receptor for phosphatidylserine (PS), and this is associated with reduced …
We show that metastatic disease in the pleural and peritoneal cavities is associated with poor clinical outcomes after ICB therapy. Cavity-r …
The expansion of human T-bet(high)CD21(low) B cells is T cell dependent.
Keller B, Strohmeier V, Harder I, Unger S, Payne KJ, Andrieux G, Boerries M, Felixberger PT, Landry JJM, Nieters A, Rensing-Ehl A, Salzer U, Frede N, Usadel S, Elling R, Speckmann C, Hainmann I, Ralph E, Gilmour K, Wentink MWJ, van der Burg M, Kuehn HS, Rosenzweig SD, Kölsch U, von Bernuth H, Kaiser-Labusch P, Gothe F, Hambleton S, Vlagea AD, Garcia Garcia A, Alsina L, Markelj G, Avcin T, Vasconcelos J, Guedes M, Ding JY, Ku CL, Shadur B, Avery DT, Venhoff N, Thiel J, Becker H, Erazo-Borrás L, Trujillo-Vargas CM, Franco JL, Fieschi C, Okada S, Gray PE, Uzel G, Casanova JL, Fliegauf M, Grimbacher B, Eibel H, Ehl S, Voll RE, Rizzi M, Stepensky P, Benes V, Ma CS, Bossen C, Tangye SG, Warnatz K. Keller B, et al. Sci Immunol. 2021 Oct 15;6(64):eabh0891. doi: 10.1126/sciimmunol.abh0891. Epub 2021 Oct 8. Sci Immunol. 2021. PMID: 34623902
Investigating essential signals for generating these cells in vitro established that B cell receptor (BCR)/interferon-gamma receptor (IFNgammaR) costimulation induced the highest levels of T-bet expression and enabled their differentiation during cell cultures with Toll-li …
Investigating essential signals for generating these cells in vitro established that B cell receptor (BCR)/interferon-gamma receptor (IFNgam …
Red blood cell storage lesion.
Kor DJ, Van Buskirk CM, Gajic O. Kor DJ, et al. Bosn J Basic Med Sci. 2009 Oct;9 Suppl 1(Suppl 1):S21-S27. doi: 10.17305/bjbms.2009.2750. Bosn J Basic Med Sci. 2009. PMID: 19912115 Free PMC article. Review.
Simultaneously, a variety of changes have been identified within the RBC and storage media during RBC preservation that are correlated with reduced tissue oxygenation and transfusion-associated adverse effects. ...The accumulation of biologic response modifiers such as sol …
Simultaneously, a variety of changes have been identified within the RBC and storage media during RBC preservation that are correlated with …
Lymphocyte Activation Gene-3 Regulates Dendritic Cell Metabolic Programing and T Cell Priming Function.
Garcia Cruz D, Giri RR, Gamiotea Turro D, Balsbaugh JL, Adler AJ, Rodriguez A. Garcia Cruz D, et al. J Immunol. 2021 Nov 1;207(9):2374-2384. doi: 10.4049/jimmunol.2001188. Epub 2021 Sep 29. J Immunol. 2021. PMID: 34588222 Free PMC article.
Results showed that Lag3 (-/-) BMDCs secreted more TNF-alpha, were more glycolytic, used fewer fatty acids for mitochondrial respiration, and glycolysis was significantly reduced by exogenous IL-10 treatment. Under basal conditions, RNA sequencing revealed increased exp …
Results showed that Lag3 (-/-) BMDCs secreted more TNF-alpha, were more glycolytic, used fewer fatty acids for mitochondrial respiration, an …
CD40- and CD95-specific antibody single chain-Baff fusion proteins display BaffR-, TACI- and BCMA-restricted agonism.
Nelke J, Medler J, Weisenberger D, Beilhack A, Wajant H. Nelke J, et al. MAbs. 2020 Jan-Dec;12(1):1807721. doi: 10.1080/19420862.2020.1807721. MAbs. 2020. PMID: 32840410 Free PMC article.
Cellular binding studies showed that the binding properties of the different domains within the fusion proteins remained fully intact in the antibody-scBaff fusion proteins. In co-culture assays of CD40- and CD95-responsive cells with BaffR, BCMA or TACI expressing …
Cellular binding studies showed that the binding properties of the different domains within the fusion proteins remained fully intact in the …
B-cell capacity for differentiation changes with age.
Xie X, Shrimpton J, Doody GM, Conaghan PG, Ponchel F. Xie X, et al. Aging Cell. 2021 Apr;20(4):e13341. doi: 10.1111/acel.13341. Epub 2021 Mar 12. Aging Cell. 2021. PMID: 33711204 Free PMC article.
Antibody secretion was measured by ELISA and gene expression using qPCR. RESULTS: TI and TD differentiation resulted in effective proliferation of B cells followed by their differentiation into PC. ...In contrast, in TI differentiation age significantly affected pro …
Antibody secretion was measured by ELISA and gene expression using qPCR. RESULTS: TI and TD differentiation resulted in effect …
ASPN Is a Potential Biomarker and Associated with Immune Infiltration in Endometriosis.
Wang L, Sun J. Wang L, et al. Genes (Basel). 2022 Jul 28;13(8):1352. doi: 10.3390/genes13081352. Genes (Basel). 2022. PMID: 36011263 Free PMC article.
Methods: We obtained the GSE141549 and GSE7305 datasets containing endometriosis and normal endometrial samples from the Gene Expression Omnibus database (GEO). In the GSE141549 dataset, differentially expressed genes (DEGs) were found. ...Immune checkpoint …
Methods: We obtained the GSE141549 and GSE7305 datasets containing endometriosis and normal endometrial samples from the Gene Expr …
Abnormal Function of Circulating Follicular Helper T Cells Leads to Different Manifestations of B Cell Maturation and Differentiation in Patients with Osteosarcoma.
Zhao G, Liang J, Cao J, Jiang S, Lu J, Jiang B. Zhao G, et al. J Healthc Eng. 2022 Apr 19;2022:3724033. doi: 10.1155/2022/3724033. eCollection 2022. J Healthc Eng. 2022. PMID: 35494526 Free PMC article.
Flow cytometry was employed to identify proportions of CD4+CXCR5+Tfh cells and Tfh cell subtypes Tfh17, Tfh1, and Tfh2 in the patient's peripheral blood. CD40 L and IFNgamma levels were detected after stimulating Tfh cells with an influenza antigen; the positive rates of C …
Flow cytometry was employed to identify proportions of CD4+CXCR5+Tfh cells and Tfh cell subtypes Tfh17, Tfh1, and Tfh2 in the patient's peri …
Dimethyl fumarate influences innate and adaptive immunity in multiple sclerosis.
Diebold M, Sievers C, Bantug G, Sanderson N, Kappos L, Kuhle J, Lindberg RLP, Derfuss T. Diebold M, et al. J Autoimmun. 2018 Jan;86:39-50. doi: 10.1016/j.jaut.2017.09.009. Epub 2017 Sep 27. J Autoimmun. 2018. PMID: 28958667
Interestingly, this anti-proliferative effect decreased under treatment. In-vivo DMF treatment led to decreased T cell glycolysis and higher turn-over of antioxidants. In line with these results a significant increase of cytosolic ROS levels after 3 months treatment …
Interestingly, this anti-proliferative effect decreased under treatment. In-vivo DMF treatment led to decreased T cell glycoly …
CD22L Conjugation to Insulin Attenuates Insulin-Specific B Cell Activation.
Apley KD, Griffith AS, Downes GM, Ross P, Farrell MP, Kendall P, Berkland CJ. Apley KD, et al. Bioconjug Chem. 2023 Nov 15;34(11):2077-2088. doi: 10.1021/acs.bioconjchem.3c00391. Epub 2023 Oct 26. Bioconjug Chem. 2023. PMID: 37883211
Duplicate wells with anti-CD40 simulated T cell help. A 2-insulin 4-arm PEG control caused robust proliferation and activation-induced CD86 upregulation. ...Thus, multivalent antigen constructs tend to activate anti-insulin B cells, while monomeric antigen-CD …
Duplicate wells with anti-CD40 simulated T cell help. A 2-insulin 4-arm PEG control caused robust proliferation and act …
67 results