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Quoted phrase not found in phrase index: "Reduced beta-hexosaminidase activity"
Page 1
Botulinum toxin blocks mast cells and prevents rosacea like inflammation.
Choi JE, Werbel T, Wang Z, Wu CC, Yaksh TL, Di Nardo A. Choi JE, et al. J Dermatol Sci. 2019 Jan;93(1):58-64. doi: 10.1016/j.jdermsci.2018.12.004. Epub 2018 Dec 28. J Dermatol Sci. 2019. PMID: 30658871 Free PMC article.
METHODS: Primary human and murine mast cells were pretreated with onabotulinum toxin A or B or control. Mast cell degranulation was evaluated by beta-hexosaminidase activity. Expression of botulinum toxin receptor Sv2 was measured by qPCR. ...CONCLUSIONS: The …
METHODS: Primary human and murine mast cells were pretreated with onabotulinum toxin A or B or control. Mast cell degranulation was evaluate …
Nano-silica particles synergistically IgE-mediated mast cell activation exacerbating allergic inflammation in mice.
Yang YS, Cao MD, Wang A, Liu QM, Zhu DX, Zou Y, Ma LL, Luo M, Shao Y, Xu DD, Wei JF, Sun JL. Yang YS, et al. Front Immunol. 2022 Jul 22;13:911300. doi: 10.3389/fimmu.2022.911300. eCollection 2022. Front Immunol. 2022. PMID: 35936002 Free PMC article.
RESULTS: Only 20 nm SiO(2) particles significantly increased beta-hexosaminidase release, based on dinitrophenol (DNP)-human serum albumin (HSA) stimulation, from IgE-sensitized mast cells, while other particles did not. ...The ERK inhibitors showed a significant in …
RESULTS: Only 20 nm SiO(2) particles significantly increased beta-hexosaminidase release, based on dinitrophenol (DNP)-human s …
Brain endothelial specific gene therapy improves experimental Sandhoff disease.
Dogbevia G, Grasshoff H, Othman A, Penno A, Schwaninger M. Dogbevia G, et al. J Cereb Blood Flow Metab. 2020 Jun;40(6):1338-1350. doi: 10.1177/0271678X19865917. Epub 2019 Jul 29. J Cereb Blood Flow Metab. 2020. PMID: 31357902 Free PMC article.
In Tay-Sachs and Sandhoff disease, a deficiency of the lysosomal enzyme beta-hexosaminidase causes GM2 and other gangliosides to accumulate in neurons and triggers neurodegeneration. ...Here, we tested in Hexb(-/-) mice, a model of Sandhoff disease, to determine whe …
In Tay-Sachs and Sandhoff disease, a deficiency of the lysosomal enzyme beta-hexosaminidase causes GM2 and other gangliosides …
Antiallergic activities of shallot (Allium ascalonicum L.) and its therapeutic effects in allergic rhinitis.
Arpornchayanon W, Klinprung S, Chansakaow S, Hanprasertpong N, Chaiyasate S, Tokuda M, Tamura H. Arpornchayanon W, et al. Asian Pac J Allergy Immunol. 2022 Dec;40(4):393-400. doi: 10.12932/AP-300319-0529. Asian Pac J Allergy Immunol. 2022. PMID: 31421664 Free article. Clinical Trial.
METHODS: In-vitro beta-hexosaminidase inhibitory activities of shallot was compared with onion on RBL-2H3 cells. In clinical study, a randomized, double-blind, placebo-controlled trial was performed. ...
METHODS: In-vitro beta-hexosaminidase inhibitory activities of shallot was compared with onion on RBL-2H3 cells. In …
O-linked beta-N-acetylglucosaminidase inhibitor attenuates beta-amyloid plaque and rescues memory impairment.
Kim C, Nam DW, Park SY, Song H, Hong HS, Boo JH, Jung ES, Kim Y, Baek JY, Kim KS, Cho JW, Mook-Jung I. Kim C, et al. Neurobiol Aging. 2013 Jan;34(1):275-85. doi: 10.1016/j.neurobiolaging.2012.03.001. Epub 2012 Apr 11. Neurobiol Aging. 2013. PMID: 22503002
Deposition of beta-amyloid (Abeta) as senile plaques and disrupted glucose metabolism are two main characteristics of Alzheimer's disease (AD). ...We found that 1,2-dideoxy-2'-propyl-alpha-d-glucopyranoso-[2,1-D]-delta2'-thiazoline (NButGT), a specific inhibitor of O-GlcNA …
Deposition of beta-amyloid (Abeta) as senile plaques and disrupted glucose metabolism are two main characteristics of Alzheimer's dis …
Integrative lipidomic features identify plasma lipid signatures in chronic urticaria.
Li J, Li L, Liu R, Zhu L, Zhou B, Xiao Y, Hou G, Lin L, Chen X, Peng C. Li J, et al. Front Immunol. 2022 Jul 28;13:933312. doi: 10.3389/fimmu.2022.933312. eCollection 2022. Front Immunol. 2022. PMID: 35967440 Free PMC article.
Functional validation studies were performed in vitro and in vivo including beta-hexosaminidase release examination from mast cells and passive cutaneous anaphylaxis (PCA) mouse model. ...Phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylglycer …
Functional validation studies were performed in vitro and in vivo including beta-hexosaminidase release examination from mast …
MP29-02 reduces nasal hyperreactivity and nasal mediators in patients with house dust mite-allergic rhinitis.
Kortekaas Krohn I, Callebaut I, Alpizar YA, Steelant B, Van Gerven L, Skov PS, Kasran A, Talavera K, Wouters MM, Ceuppens JL, Seys SF, Hellings PW. Kortekaas Krohn I, et al. Allergy. 2018 May;73(5):1084-1093. doi: 10.1111/all.13349. Epub 2018 Jan 17. Allergy. 2018. PMID: 29121401 Clinical Trial.

RESULTS: MP29-02 but not placebo reduced NHR (P < .0001 vs P = .21), levels of substance P (P = .026 vs P = .941), and beta-hexosaminidase (P = .036 vs P = .632) in human nasal secretions. In wild-type C57BL6 mice, the reduction in beta-hexosamin

…

RESULTS: MP29-02 but not placebo reduced NHR (P < .0001 vs P = .21), levels of substance P (P = .026 vs P = .941), and beta

…
Effect of chemical modifications on allergenic potency of peanut proteins.
Bencharitiwong R, van der Kleij HP, Koppelman SJ, Nowak-Węgrzyn A. Bencharitiwong R, et al. Allergy Asthma Proc. 2015 May-Jun;36(3):185-91. doi: 10.2500/aap.2015.36.3840. Allergy Asthma Proc. 2015. PMID: 25976435 Free PMC article.
METHODS: Native Ara h 2/6 was reduced and alkylated (RA), with or without additional glutaraldehyde treatment (RAGA). ...Nineteen subjects were responders, NHR 10% in the mediator release assay. Responders had reduced NHR by RA and RAGA compared with the native Ara …
METHODS: Native Ara h 2/6 was reduced and alkylated (RA), with or without additional glutaraldehyde treatment (RAGA). ...Nineteen sub …
Evidence that small molecule enhancement of beta-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Abeta.
Knight EM, Williams HN, Stevens AC, Kim SH, Kottwitz JC, Morant AD, Steele JW, Klein WL, Yanagisawa K, Boyd RE, Lockhart DJ, Sjoberg ER, Ehrlich ME, Wustman BA, Gandy S. Knight EM, et al. Mol Psychiatry. 2015 Feb;20(1):109-17. doi: 10.1038/mp.2014.135. Epub 2014 Oct 28. Mol Psychiatry. 2015. PMID: 25349165 Free PMC article.
These mutant Abeta peptides may also undergo accelerated aggregation and accumulation upon exposure to GM2 and GM3. We hypothesized that increasing beta-hexosaminidase (beta-hex) activity would lead to a reduction in GM2 levels, which in turn, would ca …
These mutant Abeta peptides may also undergo accelerated aggregation and accumulation upon exposure to GM2 and GM3. We hypothesized that inc …
Genistein Activates Transcription Factor EB and Corrects Niemann-Pick C Phenotype.
Argüello G, Balboa E, Tapia PJ, Castro J, Yañez MJ, Mattar P, Pulgar R, Zanlungo S. Argüello G, et al. Int J Mol Sci. 2021 Apr 19;22(8):4220. doi: 10.3390/ijms22084220. Int J Mol Sci. 2021. PMID: 33921734 Free PMC article.
Genistein can pass the blood-brain barrier and activate TFEB. Hence, we investigated the effect of TFEB activation by genistein toward correcting the NPC phenotype. ...Genistein treatment improved lysosomal protein expression and autophagic flux, decreasing p62 leve …
Genistein can pass the blood-brain barrier and activate TFEB. Hence, we investigated the effect of TFEB activation by genistei …
62 results