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Rutaecarpine derivative Cpd-6c alleviates acute kidney injury by targeting PDE4B, a key enzyme mediating inflammation in cisplatin nephropathy.
Liu XQ, Jin J, Li Z, Jiang L, Dong YH, Cai YT, Wu MF, Wang JN, Ma TT, Wen JG, Liu MM, Li J, Wu YG, Meng XM. Liu XQ, et al. Biochem Pharmacol. 2020 Oct;180:114132. doi: 10.1016/j.bcp.2020.114132. Epub 2020 Jul 3. Biochem Pharmacol. 2020. PMID: 32622666
Our results showed that Cpd-6c restored renal function more effectively than Ru, as evidenced by reduced blood urea nitrogen and serum creatinine levels in mice. Cpd-6c alleviated tubular injury, as shown by PAS staining and molecular analysis of kidne …
Our results showed that Cpd-6c restored renal function more effectively than Ru, as evidenced by reduced blood urea …
Cardiac resynchronization therapy improves renal function in human heart failure with reduced glomerular filtration rate.
Boerrigter G, Costello-Boerrigter LC, Abraham WT, Sutton MG, Heublein DM, Kruger KM, Hill MR, McCullough PA, Burnett JC Jr. Boerrigter G, et al. J Card Fail. 2008 Sep;14(7):539-46. doi: 10.1016/j.cardfail.2008.03.009. Epub 2008 May 27. J Card Fail. 2008. PMID: 18722318 Free PMC article. Clinical Trial.
Compared with control, CRT increased eGFR (-2.4 +/- 1.2 vs. +2.7 +/- 1.2 mL/min per 1.73 m(2); P = .003) and reduced blood urea nitrogen (+6.4 +/- 2.4 vs. -1.1 +/- 1.5 mg/mL; P = .008) in category C, whereas no differences were observed in categ …
Compared with control, CRT increased eGFR (-2.4 +/- 1.2 vs. +2.7 +/- 1.2 mL/min per 1.73 m(2); P = .003) and reduced blood …
Expression and function of transforming growth factor β in melioidosis.
Weehuizen TA, Wieland CW, van der Windt GJ, Duitman JW, Boon L, Day NP, Peacock SJ, van der Poll T, Wiersinga WJ. Weehuizen TA, et al. Infect Immun. 2012 May;80(5):1853-7. doi: 10.1128/IAI.05534-11. Epub 2012 Feb 13. Infect Immun. 2012. PMID: 22331429 Free PMC article.
TGF-beta blockade appeared to be protective: mice treated with anti-TGF-beta antibody and subsequently infected with B. pseudomallei showed diminished bacterial loads. Moreover, less distant organ injury was observed in anti-TGF-beta treated mice as shown by reduced …
TGF-beta blockade appeared to be protective: mice treated with anti-TGF-beta antibody and subsequently infected with B. pseudomallei showed …
Conditional VHL gene deletion activates a local NO-VEGF axis in a balanced manner reinforcing resistance to endothelium-targeted glomerulonephropathy.
Morita T, Kakinuma Y, Kurabayashi A, Fujieda M, Sato T, Shuin T, Furihata M, Wakiguchi H. Morita T, et al. Nephrol Dial Transplant. 2011 Dec;26(12):4023-31. doi: 10.1093/ndt/gfr176. Epub 2011 Apr 14. Nephrol Dial Transplant. 2011. PMID: 21493813
METHODS AND RESULTS: VHL-KO mice with HV glomerulonephropathy (HV GN) had fewer injured glomeruli, a lower mesangiolysis score and reduced blood urea nitrogen levels. Immunoreactivity of vascular endothelial growth factor (VEGF) in the glomerula …
METHODS AND RESULTS: VHL-KO mice with HV glomerulonephropathy (HV GN) had fewer injured glomeruli, a lower mesangiolysis score and …