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Quoted phrase not found in phrase index: "Reduced bone-marrow megakaryocyte size"
Page 1
Relation of platelet abnormalities to thrombosis and hemorrhage in chronic myeloproliferative disorders.
Wehmeier A, Südhoff T, Meierkord F. Wehmeier A, et al. Semin Thromb Hemost. 1997;23(4):391-402. doi: 10.1055/s-2007-996114. Semin Thromb Hemost. 1997. PMID: 9263357 Review.
Cytoreductive drugs may partly improve platelet dysfunction, and platelet inhibitory agents reduce symptoms of platelet activation. However, neither of these therapeutic principles is able to normalize platelet function in MPD. As an alternative to conventional treatment, …
Cytoreductive drugs may partly improve platelet dysfunction, and platelet inhibitory agents reduce symptoms of platelet activation. H …
Developmental differences between newborn and adult mice in response to romiplostim.
Sparger KA, Ramsey H, Lorenz V, Liu ZJ, Feldman HA, Li N, Laforest T, Sola-Visner MC. Sparger KA, et al. Platelets. 2018 Jun;29(4):365-372. doi: 10.1080/09537104.2017.1316481. Epub 2017 May 26. Platelets. 2018. PMID: 28548028 Free PMC article.
Both sets of mice responded with dose-dependent platelet and IPF increases, peaking on days 5-7 post-treatment, but neonates had a blunted response (2.1-fold compared to 4.2-fold maximal increase in platelet counts, respectively). On day 5 post-treatment with 300 ng/g ROM, MKs in …
Both sets of mice responded with dose-dependent platelet and IPF increases, peaking on days 5-7 post-treatment, but neonates had a blunted r …
Peripheral and intrasplenic platelet kinetics and bone marrow megakaryopoiesis in alpha-2b-interferon treated hairy cell leukemia.
Wadenvik H, Braide I, Ridell B, Kutti J, Jacobsson S, Revesz P. Wadenvik H, et al. Leuk Res. 1994 Aug;18(8):569-75. doi: 10.1016/0145-2126(94)90038-8. Leuk Res. 1994. PMID: 8065159
At the time when treatment was initiated, the patients were heterogeneous as regards the spleen size, platelet kinetics, and the bone marrow morphology. Three patients had values for P below the 95th percentile for a group of healthy control subjects; followi …
At the time when treatment was initiated, the patients were heterogeneous as regards the spleen size, platelet kinetics, and the b …
The role of alpha-interferon in essential thrombocythaemia, polycythaemia vera and myelofibrosis with myeloid metaplasia (MMM): a concise update.
Sacchi S. Sacchi S. Leuk Lymphoma. 1995 Sep;19(1-2):13-20. doi: 10.3109/10428199509059658. Leuk Lymphoma. 1995. PMID: 8574158 Review.
To date, there is no generally accepted treatment for these diseases which can reduce the risk of thromboembolism and/or haemorrhagic events, avoid any increase in the frequency of secondary myelofibrosis and terminal blast transformation and decrease the reticulin content …
To date, there is no generally accepted treatment for these diseases which can reduce the risk of thromboembolism and/or haemorrhagic …
Megakaryocyte features and bcr/abl translocation in chronic myeloid leukemia following imatinib mesylate (STI571) therapy--a fluorescence in-situ hybridization study.
Thiele J, Kvasnicka HM, Varus E, Ollig E, Schmitt-Graeff A, Staib P, Griesshammer M. Thiele J, et al. Leuk Lymphoma. 2004 Aug;45(8):1627-31. doi: 10.1080/10428190410001683732. Leuk Lymphoma. 2004. PMID: 15370216
Following therapy with imatinib (STI571) hematologic and cytogenetic response in chronic myeloid leukemia (CML) is associated with conspicuous alterations of bone marrow (BM) morphology. Besides reduction of cellularity and fibrosis, small megakaryocytes char …
Following therapy with imatinib (STI571) hematologic and cytogenetic response in chronic myeloid leukemia (CML) is associated with conspicuo …
Osteolytic Lesions in Primary Myelofibrosis and Effect of Ruxolitinib Therapy: Report of a Case and Literature Review.
Bucelli C, Cattaneo D, Valli VB, Levati GV, Lonati S, Gianelli U, Iurlo A. Bucelli C, et al. Chemotherapy. 2018;63(6):340-344. doi: 10.1159/000497246. Epub 2019 Apr 9. Chemotherapy. 2018. PMID: 30965327
By week 8, the patient had near resolution of constitutional symptoms and a reduction of > 50% of the spleen size that normalized by 6 months; in addition, a repeat bone marrow biopsy showed a decrease in reticulin fibrosis grade. ...In conclusion, with th …
By week 8, the patient had near resolution of constitutional symptoms and a reduction of > 50% of the spleen size that normalized …
Interferon therapy, but not busulfan restores normal-sized megakaryopoiesis in CML--a comparative histo- and immunomorphometric study.
Thiele J, Zirbes T, Kvasnicka HM, Niederle N, Dammasch J, Schmidt M, Windecker R, Leder LD, Diehl V, Fischer R. Thiele J, et al. Anal Cell Pathol. 1996 Jun;11(1):31-42. Anal Cell Pathol. 1996. PMID: 8844103
To assess possible alterations of megakaryocytes associated with interferon (IFN) and busulfan (BU) therapy of Ph(1+)-CML, an immunohistochemical and morphometric study was performed on trephine biopsies of the bone marrow taken before and at varying interval …
To assess possible alterations of megakaryocytes associated with interferon (IFN) and busulfan (BU) therapy of Ph(1+)-CML, an immunoh …
Prothrombotic megakaryocyte and platelet changes in hypertension are reversed following treatment: a pilot study.
Pathansali R, Smith NM, Bath PM. Pathansali R, et al. Platelets. 2001 May;12(3):144-9. doi: 10.1080/09537100120039000. Platelets. 2001. PMID: 11304415
Platelets are formed from, and their function determined by, bone marrow megakaryocytes (MK). Previous studies have found that hypertension is associated with accentuated platelet function and that some antihypertensive drug classes have antiplatelet activity …
Platelets are formed from, and their function determined by, bone marrow megakaryocytes (MK). Previous studies have fou …
Large granular lymphocyte leukemia with pure red cell aplasia in a renal transplant recipient.
Masuda M, Arai Y, Nishina H, Fuchinoue S, Mizoguchi H. Masuda M, et al. Am J Hematol. 1998 Jan;57(1):72-6. doi: 10.1002/(sici)1096-8652(199801)57:1<72::aid-ajh13>3.0.co;2-b. Am J Hematol. 1998. PMID: 9423821 Free article.
Laboratory findings were as follows: RBC 1.46 x 10(12)/L; hemoglobin 5.8 g/dl; hematocrit 17.8%; leucocytes 5.2 x 10(9)/L with 62.4% neutrophils, 34.1% lymphocytes, 2.6% monocytes; platelets 50.8 x 10(10)/L; reticulocytes 0.4%. Bone marrow aspirate smears and biopsy …
Laboratory findings were as follows: RBC 1.46 x 10(12)/L; hemoglobin 5.8 g/dl; hematocrit 17.8%; leucocytes 5.2 x 10(9)/L with 62.4% neutrop …
A case of pure red cell aplasia during nivolumab therapy for cardiac metastatic melanoma.
Yuki A, Takenouchi T, Takatsuka S, Ishiguro T. Yuki A, et al. Melanoma Res. 2017 Dec;27(6):635-637. doi: 10.1097/CMR.0000000000000392. Melanoma Res. 2017. PMID: 28872489
Blood test results indicated normocytic, normochromic anemia, and reticulocytopenia, but all other components were normal. Bone marrow aspiration showed increased megakaryocytes and decreased erythroblasts; these findings were consistent with PRCA. ...PRCA mi …
Blood test results indicated normocytic, normochromic anemia, and reticulocytopenia, but all other components were normal. Bone ma …