Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 2
1994 1
1995 1
1996 1
1999 3
2001 2
2004 2
2005 1
2007 1
2009 3
2010 3
2011 2
2012 2
2013 2
2014 1
2015 2
2017 4
2018 4
2019 4
2021 2
2022 1
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

41 results

Results by year

Filters applied: . Clear all
Quoted phrase not found in phrase index: "Reduced circulating pyrimidine 5-prime-nucleotidase activity"
Page 1
ROS/PI3K/Akt and Wnt/beta-catenin signalings activate HIF-1alpha-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.
Dong S, Liang S, Cheng Z, Zhang X, Luo L, Li L, Zhang W, Li S, Xu Q, Zhong M, Zhu J, Zhang G, Hu S. Dong S, et al. J Exp Clin Cancer Res. 2022 Jan 8;41(1):15. doi: 10.1186/s13046-021-02229-6. J Exp Clin Cancer Res. 2022. PMID: 34998404 Free PMC article.
The protein levels of hypoxia inducible factor 1alpha (HIF-1alpha) in primary tumors and circulating tumor cells of CRC patients were detected by immunohistochemistry and immunofluorescence. ...Upregulation of HIF-1alpha in 5-FU-resistant CRC occurred through non-oxygen-de …
The protein levels of hypoxia inducible factor 1alpha (HIF-1alpha) in primary tumors and circulating tumor cells of CRC patients were …
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.
Hickson LJ, Langhi Prata LGP, Bobart SA, Evans TK, Giorgadze N, Hashmi SK, Herrmann SM, Jensen MD, Jia Q, Jordan KL, Kellogg TA, Khosla S, Koerber DM, Lagnado AB, Lawson DK, LeBrasseur NK, Lerman LO, McDonald KM, McKenzie TJ, Passos JF, Pignolo RJ, Pirtskhalava T, Saadiq IM, Schaefer KK, Textor SC, Victorelli SG, Volkman TL, Xue A, Wentworth MA, Wissler Gerdes EO, Zhu Y, Tchkonia T, Kirkland JL. Hickson LJ, et al. EBioMedicine. 2019 Sep;47:446-456. doi: 10.1016/j.ebiom.2019.08.069. Epub 2019 Sep 18. EBioMedicine. 2019. PMID: 31542391 Free PMC article.
Senescent cell and macrophage/Langerhans cell markers and circulating SASP factors were assayed. FINDINGS: D + Q reduced adipose tissue senescent cell burden within 11 days, with decreases in p16(INK4A)-and p21(CIP1)-expressing cells, cells with senescence-associate …
Senescent cell and macrophage/Langerhans cell markers and circulating SASP factors were assayed. FINDINGS: D + Q reduced adipo …
Targeting senescent cells alleviates obesity-induced metabolic dysfunction.
Palmer AK, Xu M, Zhu Y, Pirtskhalava T, Weivoda MM, Hachfeld CM, Prata LG, van Dijk TH, Verkade E, Casaclang-Verzosa G, Johnson KO, Cubro H, Doornebal EJ, Ogrodnik M, Jurk D, Jensen MD, Chini EN, Miller JD, Matveyenko A, Stout MB, Schafer MJ, White TA, Hickson LJ, Demaria M, Garovic V, Grande J, Arriaga EA, Kuipers F, von Zglinicki T, LeBrasseur NK, Campisi J, Tchkonia T, Kirkland JL. Palmer AK, et al. Aging Cell. 2019 Jun;18(3):e12950. doi: 10.1111/acel.12950. Epub 2019 Mar 25. Aging Cell. 2019. PMID: 30907060 Free PMC article.
Although senescent cells accumulate in adipose tissue of obese humans and rodents, a direct pathogenic role for these cells in the development of diabetes remains to be demonstrated. Here, we show that reducing senescent cell burden in obese mice, either by activating …
Although senescent cells accumulate in adipose tissue of obese humans and rodents, a direct pathogenic role for these cells in the developme …
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): a disease of two genomes.
Hirano M, Nishigaki Y, Martí R. Hirano M, et al. Neurologist. 2004 Jan;10(1):8-17. doi: 10.1097/01.nrl.0000106919.06469.04. Neurologist. 2004. PMID: 14720311 Review.
TP protein catalyzes phosphorolysis of thymidine to thymine and deoxyribose 1-phosphate. In MNGIE patients, TP enzyme activity is reduced drastically, and plasma thymidine and deoxyuridine are elevated dramatically. ...Reduction of circulating thymidine and d …
TP protein catalyzes phosphorolysis of thymidine to thymine and deoxyribose 1-phosphate. In MNGIE patients, TP enzyme activity is …
DNA damage response in workers exposed to low-dose ionising radiation.
Gaetani S, Monaco F, Bracci M, Ciarapica V, Impollonia G, Valentino M, Tomasetti M, Santarelli L, Amati M. Gaetani S, et al. Occup Environ Med. 2018 Oct;75(10):724-729. doi: 10.1136/oemed-2018-105094. Epub 2018 Aug 7. Occup Environ Med. 2018. PMID: 30087158
DNA damage (single-strand breaks, oxidised purine and pyrimidine bases) and DNA repair (t(1/2), half time to repair DNA damage, amount of repaired DNA and DNA repair activity) were measured in lymphocytes using the comet assay. ...A significant increase in DNA damag …
DNA damage (single-strand breaks, oxidised purine and pyrimidine bases) and DNA repair (t(1/2), half time to repair DNA damage, amoun …
CPX-351: a nanoscale liposomal co-formulation of daunorubicin and cytarabine with unique biodistribution and tumor cell uptake properties.
Mayer LD, Tardi P, Louie AC. Mayer LD, et al. Int J Nanomedicine. 2019 May 23;14:3819-3830. doi: 10.2147/IJN.S139450. eCollection 2019. Int J Nanomedicine. 2019. PMID: 31213803 Free PMC article. Review.
The CPX-351 liposome, which is formulated to contain bilayers of distearoylphosphatidylcholine, distearoylphosphatidylglycerol, and cholesterol at a 7:2:1 molar ratio and remains in a gel phase at body temperature, provides stability without polyethylene glycol, controlled releas …
The CPX-351 liposome, which is formulated to contain bilayers of distearoylphosphatidylcholine, distearoylphosphatidylglycerol, and choleste …
Primaquine for reducing Plasmodium falciparum transmission.
Graves PM, Gelband H, Garner P. Graves PM, et al. Cochrane Database Syst Rev. 2012 Sep 12;(9):CD008152. doi: 10.1002/14651858.CD008152.pub2. Cochrane Database Syst Rev. 2012. Update in: Cochrane Database Syst Rev. 2014 Jun 30;(6):CD008152. doi: 10.1002/14651858.CD008152.pub3. PMID: 22972117 Updated. Review.
We used GRADE guidelines to assess evidence quality, and this is reflected in the wording of the results: high quality ("PQ reduces ...."); moderate quality ("PQ probably reduces ..."); low quality ("PQ may reduce...."); and very low quality ("we don't know i …
We used GRADE guidelines to assess evidence quality, and this is reflected in the wording of the results: high quality ("PQ reduces . …
Effect of rosuvastatin on risk markers for venous thromboembolism in cancer.
Ades S, Douce D, Holmes CE, Cory S, Prior S, Butenas S, Callas P, Cushman M. Ades S, et al. J Thromb Haemost. 2018 Jun;16(6):1099-1106. doi: 10.1111/jth.14004. Epub 2018 Apr 29. J Thromb Haemost. 2018. PMID: 29575637 Free article. Clinical Trial.
Objectives We determined if statin administration in this high-risk population reduces the risk of VTE, based on established and emerging biomarkers. ...D-dimer, C-reactive protein (CRP), soluble (s)P-selectin, factor VIII (FVIII), thrombin generation and exploratory bioma …
Objectives We determined if statin administration in this high-risk population reduces the risk of VTE, based on established and emer …
Attenuated purinergic receptor function in patients with type 2 diabetes.
Thaning P, Bune LT, Hellsten Y, Pilegaard H, Saltin B, Rosenmeier JB. Thaning P, et al. Diabetes. 2010 Jan;59(1):182-9. doi: 10.2337/db09-1068. Epub 2009 Oct 6. Diabetes. 2010. PMID: 19808895 Free PMC article.
RESEARCH DESIGN AND METHODS: In 10 diabetic patients and 10 age-matched control subjects, leg blood flow (LBF) was measured during intrafemoral artery infusion of ATP, UTP, and ADO, eliciting a blood flow equal to knee-extensor exercise at 12 W (approximately 2.6 l/ …
RESEARCH DESIGN AND METHODS: In 10 diabetic patients and 10 age-matched control subjects, leg blood flow (LBF) was measured during in …
Combination of reduced folates with methotrexate or 5-fluorouracil. Comparison between 5-formyltetrahydrofolate (folinic acid) and 5-methyltetrahydrofolate in vitro activities.
Etienne MC, Fischel JL, Formento P, Schneider M, Guillot T, Bardon M, Milano G. Etienne MC, et al. Biochem Pharmacol. 1993 Nov 17;46(10):1767-74. doi: 10.1016/0006-2952(93)90581-g. Biochem Pharmacol. 1993. PMID: 8250962
Folinic acid (dlFA) is increasingly used in clinical oncology. The active isomer lFA is intensively metabolized into l5-methyltetrahydrofolate (l5MTHF), the relative proportions of lFA, dFA and l5MTHF in blood varying considerably between oral and i.v. ...This study …
Folinic acid (dlFA) is increasingly used in clinical oncology. The active isomer lFA is intensively metabolized into l5-methyltetrahy …
41 results