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Quoted phrase not found in phrase index: "Reduced epidermal keratin protein expression"
Page 1
MicroRNA-485-5p targets keratin 17 to regulate oral cancer stemness and chemoresistance via the integrin/FAK/Src/ERK/beta-catenin pathway.
Jang TH, Huang WC, Tung SL, Lin SC, Chen PM, Cho CY, Yang YY, Yen TC, Lo GH, Chuang SE, Wang LH. Jang TH, et al. J Biomed Sci. 2022 Jun 15;29(1):42. doi: 10.1186/s12929-022-00824-z. J Biomed Sci. 2022. PMID: 35706019 Free PMC article.
Thus, unveiling of mechanisms regulating CSCs and potential targets for developing their inhibitors will be instrumental for improving OSCC therapy. METHODS: siRNA, shRNA and miRNA that specifically target keratin 17 (KRT17) were used for modulation of gene expre …
Thus, unveiling of mechanisms regulating CSCs and potential targets for developing their inhibitors will be instrumental for improving OSCC …
Effect of abrocitinib on skin biomarkers in patients with moderate-to-severe atopic dermatitis.
Guttman-Yassky E, Facheris P, Gomez-Arias PJ, Del Duca E, Da Rosa JC, Weidinger S, Bissonnette R, Armstrong AW, Seneschal J, Eyerich K, Estrada YD, Bose SN, Xu D, Chen A, Tatulych S, Güler E, Chan G, Page KM, Kerkmann U. Guttman-Yassky E, et al. Allergy. 2024 May;79(5):1258-1270. doi: 10.1111/all.15969. Epub 2023 Dec 18. Allergy. 2024. PMID: 38108208 Clinical Trial.
RESULTS: A total of 46 patients received abrocitinib 200 mg (n = 14), abrocitinib 100 mg (n = 16), or placebo (n = 16). Abrocitinib improved AD clinical signs and reduced itch. Gene expression of MMP-12, KRT16, S100A8, S100A9, and S100A12 was significantly de …
RESULTS: A total of 46 patients received abrocitinib 200 mg (n = 14), abrocitinib 100 mg (n = 16), or placebo (n = 16). Abrocitinib improved …
Tranexamic acid improves psoriasis-like skin inflammation: Evidence from in vivo and in vitro studies.
Hseu JH, Chan CI, Vadivalagan C, Chen SJ, Yen HR, Hseu YC, Yang HL, Wu PY. Hseu JH, et al. Biomed Pharmacother. 2023 Oct;166:115307. doi: 10.1016/j.biopha.2023.115307. Epub 2023 Aug 11. Biomed Pharmacother. 2023. PMID: 37573659 Free article.
Notably, TXA suppressed IL-17-induced Nrf2-mediated keratin 17 expression. N-acetylcysteine pretreatment reversed the effects of TXA on NFkappaB, NLRP3 inflammasomes, and the Nrf2-mediated keratin 17 pathway in IL-17-induced HaCaT cells. Results further confi …
Notably, TXA suppressed IL-17-induced Nrf2-mediated keratin 17 expression. N-acetylcysteine pretreatment reversed the effects …
Reduced Expression of KRT17 Predicts Poor Prognosis in HER2(high) Breast Cancer.
Tang S, Liu W, Yong L, Liu D, Lin X, Huang Y, Wang H, Cai F. Tang S, et al. Biomolecules. 2022 Aug 25;12(9):1183. doi: 10.3390/biom12091183. Biomolecules. 2022. PMID: 36139022 Free PMC article.
Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to explore the potential mechanisms by which KRT17 expression influences patient survival. We found that KRT17 expression was significantly lower in BC tissues than …
Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to explore the potential mechanisms by …
Regulation of skin pigmentation and thickness by Dickkopf 1 (DKK1).
Yamaguchi Y, Morita A, Maeda A, Hearing VJ. Yamaguchi Y, et al. J Investig Dermatol Symp Proc. 2009 Aug;14(1):73-5. doi: 10.1038/jidsymp.2009.4. J Investig Dermatol Symp Proc. 2009. PMID: 19675559 Free PMC article. Review.
We recently demonstrated that levels of DKK1 in palmoplantar dermal fibroblasts are physiologically higher than those observed in non-palmoplantar dermal fibroblasts. Thus, the DKK1-rich mesenchyme in palmoplantar dermis affects the overlying epithelium and induces a palmo …
We recently demonstrated that levels of DKK1 in palmoplantar dermal fibroblasts are physiologically higher than those observed in non …
TGFbeta/SMAD/microRNA-486-3p Signaling Axis Mediates Keratin 17 Expression and Keratinocyte Hyperproliferation in Psoriasis.
Jiang M, Sun Z, Dang E, Li B, Fang H, Li J, Gao L, Zhang K, Wang G. Jiang M, et al. J Invest Dermatol. 2017 Oct;137(10):2177-2186. doi: 10.1016/j.jid.2017.06.005. Epub 2017 Jun 20. J Invest Dermatol. 2017. PMID: 28642156 Free article.
The mechanism of aberrant K17 expression in psoriasis has not been fully elucidated. MicroRNAs are short, single-stranded, noncoding RNAs that play important roles in regulating gene expression. Psoriasis exhibits a specific microRNA expression profile …
The mechanism of aberrant K17 expression in psoriasis has not been fully elucidated. MicroRNAs are short, single-stranded, noncoding …
Pharmacological effects of retinoids on skin cells.
Gendimenico GJ, Mezick JA. Gendimenico GJ, et al. Skin Pharmacol. 1993;6 Suppl 1:24-34. doi: 10.1159/000211161. Skin Pharmacol. 1993. PMID: 8142108 Review.
In keratinocytes, retinoids induce proliferation, resulting in epidermal hyperplasia. Retinoids also modulate epidermal differentiation, however, many of the suppressive effects of retinoids observed in vitro do not occur in vivo. ...Retinoids inhibit prolife …
In keratinocytes, retinoids induce proliferation, resulting in epidermal hyperplasia. Retinoids also modulate epidermal differ …
The transmembrane protein LRIG1 triggers melanocytic tumor development following chemically induced skin carcinogenesis.
Hoesl C, Fröhlich T, Posch C, Kneitz H, Goebeler M, Schneider MR, Dahlhoff M. Hoesl C, et al. Mol Oncol. 2021 Aug;15(8):2140-2155. doi: 10.1002/1878-0261.12945. Epub 2021 Mar 31. Mol Oncol. 2021. PMID: 33786987 Free PMC article.
Here, we analyzed the function of LRIG1 during chemically induced skin carcinogenesis in transgenic mice expressing LRIG1 in the skin under the control of the keratin 5 promoter (LRIG1-TG mice). ...In conclusion, our study demonstrated that LRIG1-TG mice develop mel …
Here, we analyzed the function of LRIG1 during chemically induced skin carcinogenesis in transgenic mice expressing LRIG1 in the skin …
CLDN1 knock out keratinocytes as a model to investigate multiple skin disorders.
Arnold KA, Moran MC, Shi H, van Vlijmen-Willems IMJJ, Rodijk-Olthuis D, Smits JPH, Brewer MG. Arnold KA, et al. Exp Dermatol. 2024 May;33(5):e15084. doi: 10.1111/exd.15084. Exp Dermatol. 2024. PMID: 38711223
CLDN1 KO cells demonstrated decreases in gene transcripts encoding the barrier protein filaggrin and the differentiation marker cytokeratin-10. ...We also detected increased proliferative KC in the basale layer of CLDN1 KO organotypic cultures. These results further …
CLDN1 KO cells demonstrated decreases in gene transcripts encoding the barrier protein filaggrin and the differentiation marke …
Biomolecular index of therapeutic efficacy in psoriasis treated with anti-TNF-α agents.
Bianchi L, Costanza G, Campione E, Ruzzetti M, Di Stefani A, Diluvio L, Giardina E, Cascella R, Cordiali-Fei P, Bonifati C, Chiricozzi A, Novelli G, Ensoli F, Orlandi A. Bianchi L, et al. G Ital Dermatol Venereol. 2018 Jun;153(3):316-325. doi: 10.23736/S0392-0488.16.05427-4. Epub 2016 Sep 14. G Ital Dermatol Venereol. 2018. PMID: 27627098 Free article. Clinical Trial.
A susceptibility gene analysis on cellular retinoic acid binding protein-II (CRABP-II), acting on keratinocyte differentiation, was also performed. ...A 0-12 MITE score was correlated with Psoriasis Area and Severity Index (PASI) and Psoriasis Disability Inde …
A susceptibility gene analysis on cellular retinoic acid binding protein-II (CRABP-II), acting on keratinocyte differentiation …
84 results