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Quoted phrase not found in phrase index: "Reduced erythrocyte 2,3-diphosphoglycerate concentration"
Page 1
Mitapivat for sickle cell disease and thalassemia.
Pilo F, Angelucci E. Pilo F, et al. Drugs Today (Barc). 2023 Mar;59(3):125-134. doi: 10.1358/dot.2023.59.3.3521880. Drugs Today (Barc). 2023. PMID: 36847623 Clinical Trial.
Mitapivat, an oral first-in-class activator of erythrocyte pyruvate kinase (PKR), was first investigated in patients with pyruvate kinase deficiency (PKD), where it was found to improve hemoglobin (Hb) concentrations in patients who did not regularly receive transfu …
Mitapivat, an oral first-in-class activator of erythrocyte pyruvate kinase (PKR), was first investigated in patients with pyruvate ki …
Measures of stored red blood cell quality.
Hess JR. Hess JR. Vox Sang. 2014 Jul;107(1):1-9. doi: 10.1111/vox.12130. Epub 2014 Jan 22. Vox Sang. 2014. PMID: 24446817 Review.
These chemical activities lead to a complex RBC storage lesion that includes haemolysis, reduced in vivo recovery, energy and membrane loss, altered oxygen release, reduced adenosine tri-phosphate and nitric oxide secretion, and shedding of toxic products. ...Specif …
These chemical activities lead to a complex RBC storage lesion that includes haemolysis, reduced in vivo recovery, energy and membran …
Dynamics of Metabolic and Oxidative Parameters of Erythrocytes during Treatment of Chronic Heart Failure with Molecular Hydrogen.
Deryugina AV, Danilova DA, Skokova AA, Brichkin YD, Pichugin VV, Medvedev AP, Ryazanov MV, Fedorov SA. Deryugina AV, et al. Bull Exp Biol Med. 2022 Sep;173(5):602-605. doi: 10.1007/s10517-022-05595-z. Epub 2022 Oct 10. Bull Exp Biol Med. 2022. PMID: 36210415
Inhalation of H(2) caused an increase in ATP concentration in both research groups, but was more pronounced after repeated inhalation. ...The increase in metabolic activity under the effect of H(2) was accompanied by a decrease in malondialdehyde concentration and a …
Inhalation of H(2) caused an increase in ATP concentration in both research groups, but was more pronounced after repeated inhalation …
Antisickling effects of 2,3-diphosphoglycerate depletion.
Poillon WN, Kim BC, Labotka RJ, Hicks CU, Kark JA. Poillon WN, et al. Blood. 1995 Jun 1;85(11):3289-96. Blood. 1995. PMID: 7756662 Free article.
The modest effect on solubility per se of removing intraerythrocytic 2,3-DPG (delta Csat = 1.6 g/dL) was amplified into a much larger antisickling effect by interaction with three other cellular variables affecting solubility and polymer content (intracellular pH, O2 saturation, …
The modest effect on solubility per se of removing intraerythrocytic 2,3-DPG (delta Csat = 1.6 g/dL) was amplified into a much larger antisi …
Impact of autotransfusion after coronary artery bypass grafting on oxygen transport.
Schmidt H, Følsgaard S, Mortensen PE, Jensen E. Schmidt H, et al. Acta Anaesthesiol Scand. 1997 Sep;41(8):995-1001. doi: 10.1111/j.1399-6576.1997.tb04826.x. Acta Anaesthesiol Scand. 1997. PMID: 9311397 Clinical Trial.
BACKGROUND: Autotransfusion of shed mediastinal blood after coronary artery bypass grafting (CABG) has been shown to reduce the requirement for allogeneic blood. We have previously demonstrated in non-randomized studies that the oxygen capacity of shed mediastinal b …
BACKGROUND: Autotransfusion of shed mediastinal blood after coronary artery bypass grafting (CABG) has been shown to reduce the requi …
Increased red cell 2,3-diphosphoglycerate levels in haemodialysis patients treated with erythropoietin.
Horina JH, Schwaberger G, Brussee H, Sauseng-Fellegger G, Holzer H, Krejs GJ. Horina JH, et al. Nephrol Dial Transplant. 1993;8(11):1219-22. Nephrol Dial Transplant. 1993. PMID: 8302459
To assess the effect of rHuEpo treatment on physical performance we evaluated physical working capacity, oxygen uptake and red cell 2,3-diphosphoglycerate (DPG) values at rest and during and after exercise on a bicycle spiroergometer in eight chronically haem …
To assess the effect of rHuEpo treatment on physical performance we evaluated physical working capacity, oxygen uptake and red cell 2 …
Cellular phosphate metabolism in patients receiving bisphosphonate therapy.
Challa A, Noorwali AA, Bevington A, Russell RG. Challa A, et al. Bone. 1986;7(4):255-9. doi: 10.1016/8756-3282(86)90204-8. Bone. 1986. PMID: 3094565
It is therefore unlikely that this effect is due to an immediate action of EHBP on the luminal face of the renal brush border Pi transporter. After 2 weeks of oral EHBP, the increase in the Pi concentration in patients' erythrocytes was 31% compared with 64% in plas …
It is therefore unlikely that this effect is due to an immediate action of EHBP on the luminal face of the renal brush border Pi transporter …
Insufficient nitric oxide bioavailability: a hypothesis to explain adverse effects of red blood cell transfusion.
Roback JD, Neuman RB, Quyyumi A, Sutliff R. Roback JD, et al. Transfusion. 2011 Apr;51(4):859-66. doi: 10.1111/j.1537-2995.2011.03094.x. Transfusion. 2011. PMID: 21496047 Free PMC article.
In this model, variables associated with RBC units (storage time; 2,3-diphosphoglycerate acid concentration) and transfusion recipients (endothelial dysfunction) collectively lead to changes in nitric oxide (NO) levels in vascular beds. Under certain c …
In this model, variables associated with RBC units (storage time; 2,3-diphosphoglycerate acid concentration) and …
Experimental prestorage filtration removes antibodies and decreases lipids in RBC supernatants mitigating TRALI in vivo.
Silliman CC, Kelher MR, Khan SY, LaSarre M, West FB, Land KJ, Mish B, Ceriano L, Sowemimo-Coker S. Silliman CC, et al. Blood. 2014 May 29;123(22):3488-95. doi: 10.1182/blood-2013-10-532424. Epub 2014 Apr 18. Blood. 2014. PMID: 24747436 Free PMC article.
Transfusion-related acute lung injury (TRALI) remains a significant cause of transfusion-related mortality with red cell transfusion. We hypothesize that prestorage filtration may reduce proinflammatory activity in the red blood cell (RBC) supernatant and prevent TRALI. .. …
Transfusion-related acute lung injury (TRALI) remains a significant cause of transfusion-related mortality with red cell transfusion. We hyp …
15 results