Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
1999 1
2012 1
2019 2
2020 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

5 results

Results by year

Filters applied: . Clear all
Quoted phrase not found in phrase index: "Reduced hepatic ornithine transcarbamylase activity"
Page 1
Zinc and protein metabolism in chronic liver diseases.
Katayama K. Katayama K. Nutr Res. 2020 Feb;74:1-9. doi: 10.1016/j.nutres.2019.11.009. Epub 2019 Nov 27. Nutr Res. 2020. PMID: 31891865 Free article. Review.
Zinc deficiency, which is frequently observed in patients with chronic liver disease, significantly affects protein metabolism. Ornithine transcarbamylase is a zinc enzyme involved in the urea cycle. Its activity decreases because of zinc deficiency, thereby …
Zinc deficiency, which is frequently observed in patients with chronic liver disease, significantly affects protein metabolism. Ornithine …
An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans.
Kurtz CB, Millet YA, Puurunen MK, Perreault M, Charbonneau MR, Isabella VM, Kotula JW, Antipov E, Dagon Y, Denney WS, Wagner DA, West KA, Degar AJ, Brennan AM, Miller PF. Kurtz CB, et al. Sci Transl Med. 2019 Jan 16;11(475):eaau7975. doi: 10.1126/scitranslmed.aau7975. Sci Transl Med. 2019. PMID: 30651324 Clinical Trial.
SYNB1020 produced l-arg and consumed NH(3) in an in vitro system. SYNB1020 reduced systemic hyperammonemia, improved survival in ornithine transcarbamylase-deficient spf(ash) mice, and decreased hyperammonemia in the thioacetamide-induced liver injury mouse m …
SYNB1020 produced l-arg and consumed NH(3) in an in vitro system. SYNB1020 reduced systemic hyperammonemia, improved survival in o …
4-Phenylbutyrate modulates ubiquitination of hepatocanalicular MRP2 and reduces serum total bilirubin concentration.
Hayashi H, Mizuno T, Horikawa R, Nagasaka H, Yabuki T, Takikawa H, Sugiyama Y. Hayashi H, et al. J Hepatol. 2012 May;56(5):1136-1144. doi: 10.1016/j.jhep.2011.11.021. Epub 2012 Jan 13. J Hepatol. 2012. PMID: 22245901
We investigated the effects of 4-phenylbutyrate (4PBA), a drug used to treat ornithine transcarbamylase deficiency (OTCD), on the cell surface expression and transport function of MRP2/Mrp2 and serum T-Bil concentration. ...In patients with OTCD, hepatic MRP2 …
We investigated the effects of 4-phenylbutyrate (4PBA), a drug used to treat ornithine transcarbamylase deficiency (OTCD), on …
Efficient mitochondrial import of newly synthesized ornithine transcarbamylase (OTC) and correction of secondary metabolic alterations in spf(ash) mice following gene therapy of OTC deficiency.
Zimmer KP, Bendiks M, Mori M, Kominami E, Robinson MB, Ye X, Wilson JM. Zimmer KP, et al. Mol Med. 1999 Apr;5(4):244-53. Mol Med. 1999. PMID: 10448647 Free PMC article.
BACKGROUND: The mouse strain sparse fur with abnormal skin and hair (spf(ash)) is a model for the human ornithine transcarbamylase (OTC) deficiency, an X-linked inherited urea cycle disorder. ...In Ad.mOTC-treated mice, the hepatic mitochondrial concentration …
BACKGROUND: The mouse strain sparse fur with abnormal skin and hair (spf(ash)) is a model for the human ornithine transcarbamylase …
Hepatic glutamine synthetase deficiency in fatal hyperammonemia after lung transplantation.
Tuchman M, Lichtenstein GR, Rajagopal BS, McCann MT, Furth EE, Bavaria J, Kaplan PB, Gibson JB, Berry GT. Tuchman M, et al. Ann Intern Med. 1997 Sep 15;127(6):446-9. doi: 10.7326/0003-4819-127-6-199709150-00005. Ann Intern Med. 1997. PMID: 9313001
RESULTS: Activities of carbamoyl phosphate synthetase I and ornithine carbamoyltransferase in the liver were normal. The activity of hepatic glutamine synthetase was markedly reduced (in patient 1, 12% of the mean value in controls; in pa …
RESULTS: Activities of carbamoyl phosphate synthetase I and ornithine carbamoyltransferase in the liver were normal. Th …