Geospatial Immune Heterogeneity Reflects the Diverse Tumor-Immune Interactions in Intrahepatic Cholangiocarcinoma.
Lin Y, Peng L, Dong L, Liu D, Ma J, Lin J, Chen X, Lin P, Song G, Zhang M, Liu Y, Rao J, Wei C, Lu Y, Zhang S, Ding G, Peng Z, Lu H, Wang X, Zhou J, Fan J, Wu K, Gao Q.
Lin Y, et al.
Cancer Discov. 2022 Oct 5;12(10):2350-2371. doi: 10.1158/2159-8290.CD-21-1640.
Cancer Discov. 2022.
PMID: 35853232
Intrahepatic cholangiocarcinoma (iCCA) exhibits extensive intratumoral heterogeneity and an extremely high mortality rate. ...Notably, FGFR2 mutations and fusions correlated with low mutation burden and reduced immune infiltration. Our work delineated the dynamic tu …
Intrahepatic cholangiocarcinoma (iCCA) exhibits extensive intratumoral heterogeneity and an extremely high mortality rate. ...Notably …