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Quoted phrase not found in phrase index: "Reduced radioactive iodine uptake"
Page 1
Recombinant human TSH and radioactive iodine therapy in the management of benign multinodular goiter.
Graf H. Graf H. Eur J Endocrinol. 2015 Feb;172(2):R47-52. doi: 10.1530/EJE-14-0608. Epub 2014 Sep 4. Eur J Endocrinol. 2015. PMID: 25189867 Review.
Hence, its optimal management remains controversial; possible therapies include levothyroxine (lT4), surgery, and radioactive iodine ((131)I). Suppressive treatment with lT4 is discouraged due to the development of sub-clinical or overt hyperthyroidism and to its lo …
Hence, its optimal management remains controversial; possible therapies include levothyroxine (lT4), surgery, and radioactive iodi …
Lithium as an adjunct to radioactive iodine for the treatment of hyperthyroidism: a systematic review and meta-analysis.
Kessler L, Palla J, Baru JS, Onyenwenyi C, George AM, Lucas BP. Kessler L, et al. Endocr Pract. 2014 Jul;20(7):737-45. doi: 10.4158/EP13504.RA. Endocr Pract. 2014. PMID: 24793920 Review.
BACKGROUND: Radioactive iodine (RAI) is commonly used in the treatment of hyperthyroidism but is not uniformly successful. Lithium increases thyroidal iodine retention without reducing iodide uptake, increasing the radiation dose to the thyroid …
BACKGROUND: Radioactive iodine (RAI) is commonly used in the treatment of hyperthyroidism but is not uniformly successful. Lit …
Sorafenib: rays of hope in thyroid cancer.
Duntas LH, Bernardini R. Duntas LH, et al. Thyroid. 2010 Dec;20(12):1351-8. doi: 10.1089/thy.2010.0056. Epub 2010 Oct 18. Thyroid. 2010. PMID: 20954817 Review.
In another more recent phase II study, whose primary endpoint was the reinduction of radioactive iodine uptake at 26 weeks, although no reinduction of radioactive iodine uptake was observed, 59% had a beneficial response and 34% ha …
In another more recent phase II study, whose primary endpoint was the reinduction of radioactive iodine uptake at 26 we …
Organic cation transporter 3 mediates the non-norepinephrine transporter driven uptake of meta-[(211)At]astato-benzylguanidine.
Ohshima Y, Sasaki I, Watanabe S, Sakashita T, Higashi T, Ishioka NS. Ohshima Y, et al. Nucl Med Biol. 2022 Sep-Oct;112-113:44-51. doi: 10.1016/j.nucmedbio.2022.06.005. Epub 2022 Jun 30. Nucl Med Biol. 2022. PMID: 35802985

The [(211)At]MABG uptake was also reduced in OCT3-knockdown cells (p < 0.001). The radioactivity of [(211)At]MABG was significantly reduced in normal tissues by the preloading of hydrocortisone. ...CONCLUSION: Our results suggest that OCT3 is involv

…

The [(211)At]MABG uptake was also reduced in OCT3-knockdown cells (p < 0.001). The radioactivity of [(211)At]MABG wa

…
Bone metastases from differentiated thyroid carcinoma: heterogenous tumor response to radioactive Iodine therapy and overall survival.
Jannin A, Lamartina L, Moutarde C, Djennaoui M, Lion G, Chevalier B, Vantyghem MC, Deschamps F, Hadoux J, Baudin E, Schlumberger M, Leboulleux S, Do Cao C. Jannin A, et al. Eur J Nucl Med Mol Imaging. 2022 Jun;49(7):2401-2413. doi: 10.1007/s00259-022-05697-w. Epub 2022 Feb 12. Eur J Nucl Med Mol Imaging. 2022. PMID: 35149914 Free PMC article.
RESULTS: The median OS from BM diagnosis was 57 months (IQR: 24-93). In multivariate analysis, OS was significantly reduced in the case of T4 stage, (18)FDG uptake by the BM and RAI refractory status. ...The absence of extra-skeletal distant metastasis and of (18)FD …
RESULTS: The median OS from BM diagnosis was 57 months (IQR: 24-93). In multivariate analysis, OS was significantly reduced in the ca …
Digitalislike Compounds Restore hNIS Expression and Iodide Uptake Capacity in Anaplastic Thyroid Cancer.
Tesselaar MH, Crezee T, Schuurmans I, Gerrits D, Nagarajah J, Boerman OC, van Engen-van Grunsven I, Smit JWA, Netea-Maier RT, Plantinga TS. Tesselaar MH, et al. J Nucl Med. 2018 May;59(5):780-786. doi: 10.2967/jnumed.117.200675. Epub 2017 Dec 14. J Nucl Med. 2018. PMID: 29242405 Free article.
In addition, the effect of autophagy-activating DLCs on the proliferation, gene expression profile, and iodide uptake capacity of ATC cell lines was studied. Results: Diminished autophagy activity was observed in ATC tissues, and in vitro treatment of ATC cell lines …
In addition, the effect of autophagy-activating DLCs on the proliferation, gene expression profile, and iodide uptake capacity of ATC …
Pharmacokinetics and metabolism of the methyl-branched fatty acid (BMIPP) in animals and humans.
Kropp J, Eisenhut M, Ambrose KR, Knapp FF Jr, Franke WG. Kropp J, et al. J Nucl Med. 1999 Sep;40(9):1484-91. J Nucl Med. 1999. PMID: 10492369 Free article.
RESULTS: The rat heart perfusate showed one major polar metabolite observed by TLC (Rf = 0.35; solvent = benzene-dioxane-acetic acid 80:18:2). The addition of BSA/palmitate to the perfusate buffer significantly increased backdiffusion of BMIPP (Rf = 0.55), as well as re …
RESULTS: The rat heart perfusate showed one major polar metabolite observed by TLC (Rf = 0.35; solvent = benzene-dioxane-acetic acid …
Radiosynthesis and preclinical evaluation of 3'-Aza-2'-[(18)F]fluorofolic acid: a novel PET radiotracer for folate receptor targeting.
Betzel T, Müller C, Groehn V, Müller A, Reber J, Fischer CR, Krämer SD, Schibli R, Ametamey SM. Betzel T, et al. Bioconjug Chem. 2013 Feb 20;24(2):205-14. doi: 10.1021/bc300483a. Epub 2013 Jan 17. Bioconjug Chem. 2013. PMID: 23273015
A high and specific accumulation of radioactivity was observed in the kidneys (57.33 8.40% ID/g, 90 min p.i.) and salivary glands (14.09 0.93% ID/g, 90 min p.i.), which are known to express the FR and nonspecific uptake found in the liver (10.31 2.37% ID/g, 9 …
A high and specific accumulation of radioactivity was observed in the kidneys (57.33 8.40% ID/g, 90 min p.i.) and salivary gla …
Prognostic factors in patients with Hürthle cell neoplasms of the thyroid.
Lopez-Penabad L, Chiu AC, Hoff AO, Schultz P, Gaztambide S, Ordoñez NG, Sherman SI. Lopez-Penabad L, et al. Cancer. 2003 Mar 1;97(5):1186-94. doi: 10.1002/cncr.11176. Cancer. 2003. PMID: 12599224 Free article.
Tumor encapsulation was associated with improved survival. Although radioactive iodine treatment had no overall effect on survival, subgroup analysis showed that patients who received radioactive iodine for adjuvant ablation therapy had better outcomes …
Tumor encapsulation was associated with improved survival. Although radioactive iodine treatment had no overall effect on surv …
Synthesis of the PET Tracer 124I-Trametinib for MAPK/ERK Kinase Distribution and Resistance Monitoring.
Pratt EC, Isaac E, Stater EP, Yang G, Ouerfelli O, Pillarsetty N, Grimm J. Pratt EC, et al. J Nucl Med. 2020 Dec;61(12):1845-1850. doi: 10.2967/jnumed.120.241901. Epub 2020 May 22. J Nucl Med. 2020. PMID: 32444378 Free PMC article.
Importantly, uptake higher than expected was observed in the lung and heart for up to 24 h. ...The biodistribution of (124)I-trametinib was significantly reduced in mice on trametinib therapy, providing a quantitative method to observe MEK inhibition i …
Importantly, uptake higher than expected was observed in the lung and heart for up to 24 h. ...The biodistribution of (124)I-t …
37 results