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Quoted phrase not found in phrase index: "Reduced tissue medium-chain acyl-CoA dehydrogenase activity"
Page 1
Empagliflozin improves mitochondrial dysfunction in diabetic cardiomyopathy by modulating ketone body metabolism and oxidative stress.
Cai W, Chong K, Huang Y, Huang C, Yin L. Cai W, et al. Redox Biol. 2024 Feb;69:103010. doi: 10.1016/j.redox.2023.103010. Epub 2023 Dec 27. Redox Biol. 2024. PMID: 38160540 Free PMC article.
We found significant up-regulated gene 3-hydroxymethylglutaryl CoA synthetase 2 (HMGCS2) and down-regulated gene 3-hydroxybutyrate dehydrogenase (BDH1) and 3-oxoacid CoA-transferase1 (OXCT1), respectively. ...In addition, Gene ontology (GO) enrichment analysi …
We found significant up-regulated gene 3-hydroxymethylglutaryl CoA synthetase 2 (HMGCS2) and down-regulated gene 3-hydroxybutyrate …
Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: a review.
Ferrari R, Merli E, Cicchitelli G, Mele D, Fucili A, Ceconi C. Ferrari R, et al. Ann N Y Acad Sci. 2004 Nov;1033:79-91. doi: 10.1196/annals.1320.007. Ann N Y Acad Sci. 2004. PMID: 15591005 Review.
In addition to increasing the rate of fatty acid transport into mitochondria, levocarnitine reduces the intramitochondrial ratio of acetyl-CoA to free CoA, thus stimulating the activity of pyruvate dehydrogenase and increasing the oxidation of p …
In addition to increasing the rate of fatty acid transport into mitochondria, levocarnitine reduces the intramitochondrial ratio of a …
Molecular mechanisms of the anti-obesity effect of bioactive ingredients in common spices: a review.
Lu M , Cao Y , Xiao J , Song M , Ho CT . Lu M , et al. Food Funct. 2018 Sep 19;9(9):4569-4581. doi: 10.1039/c8fo01349g. Food Funct. 2018. PMID: 30168574 Review.
In this work, the molecular mechanisms of the anti-obesity effect of eight common spices are reviewed and evaluated in cell models, animal models and human subjects. Bioactive compounds from these spices are able to reduce lipid accumulation in fat cells and adipose tis …
In this work, the molecular mechanisms of the anti-obesity effect of eight common spices are reviewed and evaluated in cell models, animal m …
Peripheral muscle alterations in non-COPD smokers.
Montes de Oca M, Loeb E, Torres SH, De Sanctis J, Hernández N, Tálamo C. Montes de Oca M, et al. Chest. 2008 Jan;133(1):13-8. doi: 10.1378/chest.07-1592. Chest. 2008. PMID: 18187741
RESULTS: In smokers, type I muscle fibers cross-sectional area was decreased, and a similar trend was found in type IIa fibers. Lactate dehydrogenase levels and the percentage of fibers with low oxidative and high glycolytic capacity were increased in smokers. nNOS (96.9 + …
RESULTS: In smokers, type I muscle fibers cross-sectional area was decreased, and a similar trend was found in type IIa fibers. Lactate d …
Medium-chain acyl-CoA dehydrogenase deficiency in children with non-ketotic hypoglycemia and low carnitine levels.
Stanley CA, Hale DE, Coates PM, Hall CL, Corkey BE, Yang W, Kelley RI, Gonzales EL, Williamson JR, Baker L. Stanley CA, et al. Pediatr Res. 1983 Nov;17(11):877-84. doi: 10.1203/00006450-198311000-00008. Pediatr Res. 1983. PMID: 6646897
This assay follows the decrease in electron transfer flavoprotein fluorescence as it is reduced by acyl-CoA-acyl-CoA dehydrogenase complex. Results with octanoyl-CoA as substrate indicated that patients had less than 2.5% normal …
This assay follows the decrease in electron transfer flavoprotein fluorescence as it is reduced by acyl-CoA-acyl …
Impaired Fat Oxidation During Exercise in Long-Chain Acyl-CoA Dehydrogenase Deficiency Patients and Effect of IV-Glucose.
Madsen KL, Stemmerik MG, Buch AE, Poulsen NS, Lund AM, Vissing J. Madsen KL, et al. J Clin Endocrinol Metab. 2019 Sep 1;104(9):3610-3613. doi: 10.1210/jc.2019-00453. J Clin Endocrinol Metab. 2019. PMID: 30990523
CONTEXT: Long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency (LCHADD) affects oxidation of long-chain fatty acids (FAO) and is associated with risk of metabolic crises and episodic rhabdomyolysis. ...She had no muscle weakness and was compliant with …
CONTEXT: Long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency (LCHADD) affects oxidation of long-chain fatty ac …
Coordinated and reversible reduction of enzymes involved in terminal oxidative metabolism in skeletal muscle mitochondria from a riboflavin-responsive, multiple acyl-CoA dehydrogenase deficiency patient.
Gianazza E, Vergani L, Wait R, Brizio C, Brambilla D, Begum S, Giancaspero TA, Conserva F, Eberini I, Bufano D, Angelini C, Pegoraro E, Tramontano A, Barile M. Gianazza E, et al. Electrophoresis. 2006 Mar;27(5-6):1182-98. doi: 10.1002/elps.200500687. Electrophoresis. 2006. PMID: 16470778
Morphological and biochemical alterations included muscle lipid accumulation, low muscle carnitine content, reduction in fatty acid beta-oxidation and reduced activity of complexes I and II of the respiratory chain. Riboflavin therapy partially or totally rev …
Morphological and biochemical alterations included muscle lipid accumulation, low muscle carnitine content, reduction in fatty acid beta-oxi …
Riboflavin-responsive lipid myopathy and carnitine deficiency.
Carroll JE, Shumate JB, Brooke MH, Hagberg JM. Carroll JE, et al. Neurology. 1981 Dec;31(12):1557-9. doi: 10.1212/wnl.31.12.1557. Neurology. 1981. PMID: 7198210
We used riboflavin to treat a patient with lipid myopathy, reduced exercise capacity, intolerance to fasting, and reduced concentrations of carnitine in muscle and serum. Although carnitine concentrations did not change, exercise capacity doubled, and response to fa …
We used riboflavin to treat a patient with lipid myopathy, reduced exercise capacity, intolerance to fasting, and reduced conc …