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MRI-based quantification of renal fat in obese individuals using different image analysis approaches.
Gjela M, Askeland A, Frøkjær JB, Mellergaard M, Handberg A. Gjela M, et al. Abdom Radiol (NY). 2022 Oct;47(10):3546-3553. doi: 10.1007/s00261-022-03603-4. Epub 2022 Jul 18. Abdom Radiol (NY). 2022. PMID: 35849166
Additionally, we assessed renal fat in obese individuals and lean individuals. METHODS: This was a retrospective observational case-control study. Twenty-eight obese individuals and 14 lean controls underwent MRI with multi-point Dixon technique for PDFF maps. ...
Additionally, we assessed renal fat in obese individuals and lean individuals. METHODS: This was a retrospective observational case-c …
Increased renal uptake and urine excretion of oxidized LDL is possibly associated with formation of large calcium oxalate nephrolithiasis: a preliminary study.
Liu CJ, Ho KT, Tsai YS, Huang HS. Liu CJ, et al. World J Urol. 2023 May;41(5):1423-1430. doi: 10.1007/s00345-023-04360-9. Epub 2023 Mar 28. World J Urol. 2023. PMID: 36977786
Increased oxLDL uptake in kidney was found in nephrolithiasis patients, whereas no significantly renal expression of oxLDL was observed in controls. CONCLUSIONS: The renal uptake of oxLDL with increased oxLDL excretion from large CaOx renal stone formers, independent of in …
Increased oxLDL uptake in kidney was found in nephrolithiasis patients, whereas no significantly renal expression of oxLDL was observed
Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease.
Falkevall A, Mehlem A, Palombo I, Heller Sahlgren B, Ebarasi L, He L, Ytterberg AJ, Olauson H, Axelsson J, Sundelin B, Patrakka J, Scotney P, Nash A, Eriksson U. Falkevall A, et al. Cell Metab. 2017 Mar 7;25(3):713-726. doi: 10.1016/j.cmet.2017.01.004. Epub 2017 Feb 9. Cell Metab. 2017. PMID: 28190774 Free article.
DKD is characterized by altered glomerular filtration and proteinuria. A common observation in DKD is the presence of renal steatosis, but the mechanism(s) underlying this observation and to what extent they contribute to disease progression are unknow …
DKD is characterized by altered glomerular filtration and proteinuria. A common observation in DKD is the presence of renal
Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease.
Cansby E, Caputo M, Gao L, Kulkarni NM, Nerstedt A, Ståhlman M, Borén J, Porosk R, Soomets U, Pedrelli M, Parini P, Marschall HU, Nyström J, Howell BW, Mahlapuu M. Cansby E, et al. JCI Insight. 2020 Dec 17;5(24):e140483. doi: 10.1172/jci.insight.140483. JCI Insight. 2020. PMID: 33170807 Free PMC article.
Diabetic kidney disease (DKD) is the most common cause of severe renal disease worldwide and the single strongest predictor of mortality in diabetes patients. Kidney steatosis has emerged as a critical trigger in the pathogenesis of DKD; however, the molecular mechanism of …
Diabetic kidney disease (DKD) is the most common cause of severe renal disease worldwide and the single strongest predictor of mortal …
The mechanisms of surface chemistry effects of mesoporous silicon nanoparticles on immunotoxicity and biocompatibility.
Shahbazi MA, Hamidi M, Mäkilä EM, Zhang H, Almeida PV, Kaasalainen M, Salonen JJ, Hirvonen JT, Santos HA. Shahbazi MA, et al. Biomaterials. 2013 Oct;34(31):7776-89. doi: 10.1016/j.biomaterials.2013.06.052. Epub 2013 Jul 16. Biomaterials. 2013. PMID: 23866976
RBC hemolysis and imaging assay revealed a significant correlation between the surface chemistry, the amount of the PSi NPs adsorbed on the cell surface and the extent of morphological changes. The in vivo results showed that despite mild renal steatosis, glomerular …
RBC hemolysis and imaging assay revealed a significant correlation between the surface chemistry, the amount of the PSi NPs adsorbed on the …