Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1978 1
1980 1
1981 1
1982 1
1983 4
1984 4
1985 3
1986 4
1987 2
1988 3
1990 3
1991 4
1992 11
1993 9
1994 19
1995 13
1996 24
1997 22
1998 29
1999 48
2000 53
2001 71
2002 50
2003 78
2004 81
2005 81
2006 86
2007 100
2008 111
2009 130
2010 128
2011 144
2012 126
2013 154
2014 185
2015 211
2016 173
2017 173
2018 167
2019 178
2020 169
2021 182
2022 149
2023 150
2024 94

Text availability

Article attribute

Article type

Publication date

Search Results

3,046 results

Results by year

Filters applied: . Clear all
Quoted phrase not found in phrase index: "Reversal of Disease Phenotype"
Page 1
Pathogenesis of endometriosis: the genetic/epigenetic theory.
Koninckx PR, Ussia A, Adamyan L, Wattiez A, Gomel V, Martin DC. Koninckx PR, et al. Fertil Steril. 2019 Feb;111(2):327-340. doi: 10.1016/j.fertnstert.2018.10.013. Epub 2018 Dec 7. Fertil Steril. 2019. PMID: 30527836 Free article. Review.
The Sampson hypothesis of implanted endometrial cells following retrograde menstruation, angiogenic spread, lymphogenic spread, or the metaplasia theory cannot explain all observations if metaplasia is defined as cells with reversible changes and an abnormal behavio …
The Sampson hypothesis of implanted endometrial cells following retrograde menstruation, angiogenic spread, lymphogenic spread, or the metap …
Combining evidence from Mendelian randomization and colocalization: Review and comparison of approaches.
Zuber V, Grinberg NF, Gill D, Manipur I, Slob EAW, Patel A, Wallace C, Burgess S. Zuber V, et al. Am J Hum Genet. 2022 May 5;109(5):767-782. doi: 10.1016/j.ajhg.2022.04.001. Epub 2022 Apr 21. Am J Hum Genet. 2022. PMID: 35452592 Free PMC article. Review.
Mendelian randomization assesses whether genetic predictors of an exposure are associated with the outcome and interprets an association as evidence that the exposure has a causal effect on the outcome, whereas colocalization assesses whether two traits are affected by the …
Mendelian randomization assesses whether genetic predictors of an exposure are associated with the outcome and interprets an associat …
Increased ATF2 expression predicts poor prognosis and inhibits sorafenib-induced ferroptosis in gastric cancer.
Xu X, Li Y, Wu Y, Wang M, Lu Y, Fang Z, Wang H, Li Y. Xu X, et al. Redox Biol. 2023 Feb;59:102564. doi: 10.1016/j.redox.2022.102564. Epub 2022 Dec 2. Redox Biol. 2023. PMID: 36473315 Free PMC article.
We found that ATF2 was significantly upregulated in GC tissues and predicted a poor clinical prognosis. Silencing ATF2 significantly inhibited the malignant phenotype of GC cells. In addition, we observed that ATF2 was activated during sorafenib-induced ferro …
We found that ATF2 was significantly upregulated in GC tissues and predicted a poor clinical prognosis. Silencing ATF2 significantly …
Heterogeneity in phenotype, disease progression and drug response in type 2 diabetes.
Nair ATN, Wesolowska-Andersen A, Brorsson C, Rajendrakumar AL, Hapca S, Gan S, Dawed AY, Donnelly LA, McCrimmon R, Doney ASF, Palmer CNA, Mohan V, Anjana RM, Hattersley AT, Dennis JM, Pearson ER. Nair ATN, et al. Nat Med. 2022 May;28(5):982-988. doi: 10.1038/s41591-022-01790-7. Epub 2022 May 9. Nat Med. 2022. PMID: 35534565
Type 2 diabetes (T2D) is a complex chronic disease characterized by considerable phenotypic heterogeneity. In this study, we applied a reverse graph embedding method to routinely collected data from 23,137 Scottish patients with newly diagnosed diabetes to vi …
Type 2 diabetes (T2D) is a complex chronic disease characterized by considerable phenotypic heterogeneity. In this study, we a …
Multiomic signatures of body mass index identify heterogeneous health phenotypes and responses to a lifestyle intervention.
Watanabe K, Wilmanski T, Diener C, Earls JC, Zimmer A, Lincoln B, Hadlock JJ, Lovejoy JC, Gibbons SM, Magis AT, Hood L, Price ND, Rappaport N. Watanabe K, et al. Nat Med. 2023 Apr;29(4):996-1008. doi: 10.1038/s41591-023-02248-0. Epub 2023 Mar 20. Nat Med. 2023. PMID: 36941332 Free PMC article.
Multiomic profiling can reveal population heterogeneity for both health and disease states. Obesity drives a myriad of metabolic perturbations and is a risk factor for multiple chronic diseases. ...Machine learning model predictions of BMI from blood multiomi …
Multiomic profiling can reveal population heterogeneity for both health and disease states. Obesity drives a myriad of metabolic pert …
Characterization of a phenotype-based genetic test prediction score for unrelated patients with hypertrophic cardiomyopathy.
Bos JM, Will ML, Gersh BJ, Kruisselbrink TM, Ommen SR, Ackerman MJ. Bos JM, et al. Mayo Clin Proc. 2014 Jun;89(6):727-37. doi: 10.1016/j.mayocp.2014.01.025. Epub 2014 May 1. Mayo Clin Proc. 2014. PMID: 24793961 Free PMC article.
A score, based on the number of predictors of a positive genetic test result, predicted a positive genetic test result ranging from 6% when only hypertension was present to 80% when all 5 positive predictor markers were present. ...Although all the pat …
A score, based on the number of predictors of a positive genetic test result, predicted a positive genetic test result …
'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?
Smith GD, Ebrahim S. Smith GD, et al. Int J Epidemiol. 2003 Feb;32(1):1-22. doi: 10.1093/ije/dyg070. Int J Epidemiol. 2003. PMID: 12689998
Associations between modifiable exposures and disease seen in observational epidemiology are sometimes confounded and thus misleading, despite our best efforts to improve the design and analysis of studies. Mendelian randomization-the random assortment of genes from …
Associations between modifiable exposures and disease seen in observational epidemiology are sometimes confounded and thus mis …
Airway basal cells show a dedifferentiated KRT17(high)Phenotype and promote fibrosis in idiopathic pulmonary fibrosis.
Jaeger B, Schupp JC, Plappert L, Terwolbeck O, Artysh N, Kayser G, Engelhard P, Adams TS, Zweigerdt R, Kempf H, Lienenklaus S, Garrels W, Nazarenko I, Jonigk D, Wygrecka M, Klatt D, Schambach A, Kaminski N, Prasse A. Jaeger B, et al. Nat Commun. 2022 Sep 26;13(1):5637. doi: 10.1038/s41467-022-33193-0. Nat Commun. 2022. PMID: 36163190 Free PMC article.
Idiopathic pulmonary fibrosis (IPF) is a fatal disease with limited treatment options. In this study, we focus on the properties of airway basal cells (ABC) obtained from patients with IPF (IPF-ABC). ...We demonstrate that saracatinib modified in-vitro and in-vivo the prof …
Idiopathic pulmonary fibrosis (IPF) is a fatal disease with limited treatment options. In this study, we focus on the properties of a …
Epigenetic differences arise during the lifetime of monozygotic twins.
Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suñer D, Cigudosa JC, Urioste M, Benitez J, Boix-Chornet M, Sanchez-Aguilera A, Ling C, Carlsson E, Poulsen P, Vaag A, Stephan Z, Spector TD, Wu YZ, Plass C, Esteller M. Fraga MF, et al. Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10604-9. doi: 10.1073/pnas.0500398102. Epub 2005 Jul 11. Proc Natl Acad Sci U S A. 2005. PMID: 16009939 Free PMC article.
However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. ...These findings indicate how an appreciation of …
However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as diffe …
Investigating the shared genetic architecture of uterine leiomyoma and breast cancer: A genome-wide cross-trait analysis.
Wu X, Xiao C, Han Z, Zhang L, Zhao X, Hao Y, Xiao J, Gallagher CS, Kraft P, Morton CC, Li J, Jiang X. Wu X, et al. Am J Hum Genet. 2022 Jul 7;109(7):1272-1285. doi: 10.1016/j.ajhg.2022.05.015. Am J Hum Genet. 2022. PMID: 35803233 Free PMC article.
Little is known regarding the shared genetic architecture or causality underlying the phenotypic association observed for uterine leiomyoma (UL) and breast cancer (BC). ...Mendelian randomization demonstrated a significantly increased risk of BC overall (OR = 1.09, …
Little is known regarding the shared genetic architecture or causality underlying the phenotypic association observed for uter …
3,046 results