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Quoted phrase not found in phrase index: "SH2B3 Gene Deletion"
Page 1
Somatic homozygous loss of SH2B3, and a non-Robertsonian translocation t(15;21)(q25.3;q22.1) with NTRK3 rearrangement, in an adolescent with progenitor B-cell acute lymphoblastic leukemia with the iAMP21.
Capela de Matos RR, Othman M, Ferreira GM, Monteso K, de Souza MT, Rouxinol M, Melo JB, Carreira IM, Abdelhay E, Liehr T, Ribeiro RC, Silva M. Capela de Matos RR, et al. Cancer Genet. 2022 Apr;262-263:16-22. doi: 10.1016/j.cancergen.2021.12.003. Epub 2021 Dec 22. Cancer Genet. 2022. PMID: 34974289
Rob(15;21) or a ring chromosome 21 have been associated with an increased risk for iAMP21-ALL, suggesting that constitutional genetic abnormalities may also drive leukemogenesis. Here we describe homozygous deletion of the SH2B3 gene, chromothripsis of chromo …
Rob(15;21) or a ring chromosome 21 have been associated with an increased risk for iAMP21-ALL, suggesting that constitutional genetic abnorm …
CDKN2B downregulation and other genetic characteristics in T-acute lymphoblastic leukemia.
Jang W, Park J, Kwon A, Choi H, Kim J, Lee GD, Han E, Jekarl DW, Chae H, Han K, Yoon JH, Lee S, Chung NG, Cho B, Kim M, Kim Y. Jang W, et al. Exp Mol Med. 2019 Jan 11;51(1):1-15. doi: 10.1038/s12276-018-0195-x. Exp Mol Med. 2019. PMID: 30635552 Free PMC article.
Copy number alterations were most frequently detected in CDKN2B, CDKN2A, and genes on 9p21.3 in T-ALL (45.1%). Gene expression data demonstrated the downregulation of CDKN2B in most cases of T-ALL, whereas CDKN2A downregulation was mainly restricted to deletions. ...Genes …
Copy number alterations were most frequently detected in CDKN2B, CDKN2A, and genes on 9p21.3 in T-ALL (45.1%). Gene expression data d …
Telomere length and its correlation with gene mutations in chronic lymphocytic leukemia in a Korean population.
Song DY, Kim JA, Jeong D, Yun J, Kim SM, Lim K, Park SN, Im K, Choi S, Yoon SS, Lee DS. Song DY, et al. PLoS One. 2019 Jul 23;14(7):e0220177. doi: 10.1371/journal.pone.0220177. eCollection 2019. PLoS One. 2019. PMID: 31335885 Free PMC article.
Shorter TLs were associated with complex karyotypes (p = 0.030), del(11q22) (p = 0.023), presence of deletion and/or mutation in ATM and/or TP53 (p = 0.019), and SH2B3 mutation (p = 0.015). ...TL was attrited in CLL, and attrited telomeres were correlated with adver …
Shorter TLs were associated with complex karyotypes (p = 0.030), del(11q22) (p = 0.023), presence of deletion and/or mutation in ATM …
Detailed gene dose analysis reveals recurrent focal gene deletions in pediatric B-cell precursor acute lymphoblastic leukemia.
Ivanov Öfverholm I, Tran AN, Olsson L, Zachariadis V, Heyman M, Rudd E, Syk Lundberg E, Nordenskjöld M, Johansson B, Nordgren A, Barbany G. Ivanov Öfverholm I, et al. Leuk Lymphoma. 2016 Sep;57(9):2161-70. doi: 10.3109/10428194.2015.1136740. Epub 2016 Apr 19. Leuk Lymphoma. 2016. PMID: 27090575

INIP, IRF1 and PDE4B, were identified. Deletions of the DNA repair gene INIP were exclusively found in cases with t(12;21), and deletions of SH2B3 were associated with intrachromosomal amplification of chromosome 21 (p < 0.001). ...In cases without known risk-ass

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INIP, IRF1 and PDE4B, were identified. Deletions of the DNA repair gene INIP were exclusively found in cases with t(12;21), and delet …