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1987 2
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98 results

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Page 1
Long-term outcomes with nivolumab plus ipilimumab versus sunitinib in first-line treatment of patients with advanced sarcomatoid renal cell carcinoma.
Rini BI, Signoretti S, Choueiri TK, McDermott DF, Motzer RJ, George S, Powles T, Donskov F, Tykodi SS, Pal SK, Gupta S, Lee CW, Jiang R, Tannir NM. Rini BI, et al. J Immunother Cancer. 2022 Dec;10(12):e005445. doi: 10.1136/jitc-2022-005445. J Immunother Cancer. 2022. PMID: 36549781 Free PMC article. Clinical Trial.
BACKGROUND: Patients with advanced renal cell carcinoma with sarcomatoid features (sRCC) have a poor prognosis and limited therapeutic options. First-line nivolumab plus ipilimumab (NIVO+IPI) provided efficacy benefits over sunitinib (SUN) in patients with intermediate/poo …
BACKGROUND: Patients with advanced renal cell carcinoma with sarcomatoid features (sRCC) have a poor prognosis and limited therapeuti …
Sarcomatoid renal cell carcinoma: Biology and treatment advances.
Mouallem NE, Smith SC, Paul AK. Mouallem NE, et al. Urol Oncol. 2018 Jun;36(6):265-271. doi: 10.1016/j.urolonc.2017.12.012. Epub 2018 Jan 3. Urol Oncol. 2018. PMID: 29306556 Review.
Sarcomatoid transformation in renal cell carcinoma, so called sacromatoid RCC (sRCC), is associated with an aggressive behavior and a poor prognosis. Current therapeutic approaches are largely ineffective. ...
Sarcomatoid transformation in renal cell carcinoma, so called sacromatoid RCC (sRCC), is associated with an aggressive behavior and a poor …
Sarcomatoid renal cell carcinoma: biology, natural history and management.
Blum KA, Gupta S, Tickoo SK, Chan TA, Russo P, Motzer RJ, Karam JA, Hakimi AA. Blum KA, et al. Nat Rev Urol. 2020 Dec;17(12):659-678. doi: 10.1038/s41585-020-00382-9. Epub 2020 Oct 13. Nat Rev Urol. 2020. PMID: 33051619 Free PMC article. Review.
Sarcomatoid dedifferentiation is an uncommon feature that can occur in most histological subtypes of renal cell carcinomas (RCCs) and carries a decidedly poor prognosis. Historically, conventional treatments for sarcomatoid RCCs (sRCCs) have shown little efficacy, and medi …
Sarcomatoid dedifferentiation is an uncommon feature that can occur in most histological subtypes of renal cell carcinomas (RCCs) and carrie …
Sarcomatoid Renal Cell Carcinoma: Population-Based Study of 879 Patients.
Alevizakos M, Gaitanidis A, Nasioudis D, Msaouel P, Appleman LJ. Alevizakos M, et al. Clin Genitourin Cancer. 2019 Jun;17(3):e447-e453. doi: 10.1016/j.clgc.2019.01.005. Epub 2019 Jan 17. Clin Genitourin Cancer. 2019. PMID: 30799129
CONCLUSION: In the largest sRCC cohort to date, we found that most patients present with metastatic disease, and the prognosis for this disease remains extremely poor. Nephrectomy should be considered in all patients with acceptable surgical risk, including cytoreductive n …
CONCLUSION: In the largest sRCC cohort to date, we found that most patients present with metastatic disease, and the prognosis for th …
Sarcomatoid renal cell carcinoma: a case report and literature review.
Liang X, Liu Y, Ran P, Tang M, Xu C, Zhu Y. Liang X, et al. BMC Nephrol. 2018 Apr 10;19(1):84. doi: 10.1186/s12882-018-0884-7. BMC Nephrol. 2018. PMID: 29636020 Free PMC article. Review.
BACKGROUND: The poorly differentiated renal cell carcinoma (RCC) with rhabdomyosarcomatous sarcomatoid differentiation shows a severely aggressive biological behavior characterized by rapid disease progression. Preoperative identification of the subtype with the prognostic …
BACKGROUND: The poorly differentiated renal cell carcinoma (RCC) with rhabdomyosarcomatous sarcomatoid differentiation shows a severely aggr …
Sarcomatoid renal cell carcinoma: a comprehensive review of the biology and current treatment strategies.
Shuch B, Bratslavsky G, Linehan WM, Srinivasan R. Shuch B, et al. Oncologist. 2012;17(1):46-54. doi: 10.1634/theoncologist.2011-0227. Epub 2012 Jan 10. Oncologist. 2012. PMID: 22234634 Free PMC article. Review.
Because the sarcomatoid variant of renal cell carcinoma can account for approximately one in six cases of advanced kidney cancer, we hope to familiarize clinicians with these tumors by describing the historic background, histologic features, molecular characterization, diagnosis, …
Because the sarcomatoid variant of renal cell carcinoma can account for approximately one in six cases of advanced kidney cancer, we hope to …
Immunotherapy in metastatic sarcomatoid renal cell carcinoma: A single institution experience.
Park JJ, Kellezi O, Hamasha R, Ali A, Alva AS. Park JJ, et al. Cancer Treat Res Commun. 2020;25:100251. doi: 10.1016/j.ctarc.2020.100251. Epub 2020 Nov 23. Cancer Treat Res Commun. 2020. PMID: 33310369 Free article.
INTRODUCTION: Immune checkpoint inhibitors (CPIs) were recently approved in advanced clear cell renal cell carcinoma (RCC) and could be a promising option for metastatic RCC with sarcomatoid differentiation (sRCC) which otherwise carry a poor prognosis. We sought to compar …
INTRODUCTION: Immune checkpoint inhibitors (CPIs) were recently approved in advanced clear cell renal cell carcinoma (RCC) and could be a pr …
Sarcomatoid Chromophobe Renal Cell Carcinoma: A Case Report and Review of the Literature.
Bian L, Duan J, Wang X, Yang Y, Zhang X, Xiao S. Bian L, et al. Am J Case Rep. 2019 Aug 19;20:1225-1230. doi: 10.12659/AJCR.916651. Am J Case Rep. 2019. PMID: 31423007 Free PMC article. Review.
CONCLUSIONS Sarcomatoid chromophobe renal cell carcinoma is an uncommon tumor characterized by a biphasic tumor with both classical epithelial components and sarcomatoid components. The prognosis of sarcomatoid chromophobe renal cell carcinoma is worse than classical chrom …
CONCLUSIONS Sarcomatoid chromophobe renal cell carcinoma is an uncommon tumor characterized by a biphasic tumor with both classical epitheli …
98 results