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21 results

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Clinical pharmacology study of cariprazine (MP-214) in patients with schizophrenia (12-week treatment).
Nakamura T, Kubota T, Iwakaji A, Imada M, Kapás M, Morio Y. Nakamura T, et al. Drug Des Devel Ther. 2016 Jan 14;10:327-38. doi: 10.2147/DDDT.S95100. eCollection 2016. Drug Des Devel Ther. 2016. PMID: 26834462 Free PMC article. Clinical Trial.
METHODS: This was a multicenter, randomized, open-label, parallel-group, fixed-dose (3, 6, or 9 mg/day) study of 28-week duration (4-week observation, 12-week open-label treatment, and 12-week follow-up). Once-daily cariprazine was administered to 38 adult patients with sc …
METHODS: This was a multicenter, randomized, open-label, parallel-group, fixed-dose (3, 6, or 9 mg/day) study of 28-week duration (4-week …
Spinophilin expression in postmortem prefrontal cortex of schizophrenic subjects: Effects of antipsychotic treatment.
Brocos-Mosquera I, Gabilondo AM, Meana JJ, Callado LF, Erdozain AM. Brocos-Mosquera I, et al. Eur Neuropsychopharmacol. 2021 Jan;42:12-21. doi: 10.1016/j.euroneuro.2020.11.011. Epub 2020 Nov 27. Eur Neuropsychopharmacol. 2021. PMID: 33257116
In the present study spinophilin protein expression was determined by western blot in the postmortem dorsolateral prefrontal cortex of 24 subjects with schizophrenia (12 antipsychotic-free and 12 antipsychotic-treated subjects) and 24 matched controls. ...As previou …
In the present study spinophilin protein expression was determined by western blot in the postmortem dorsolateral prefrontal cortex of 24 su …
Neurocognitive similarities between severe chronic schizophrenia and behavioural variant frontotemporal dementia.
Chan HM, Stolwyk R, Neath J, Kelso W, Walterfang M, Mocellin R, Pantelis C, Velakoulis D. Chan HM, et al. Psychiatry Res. 2015 Feb 28;225(3):658-66. doi: 10.1016/j.psychres.2014.11.029. Epub 2014 Dec 2. Psychiatry Res. 2015. PMID: 25510904
Previous research has suggested that the pattern and severity of cognitive deficits in people with severe chronic schizophrenia is similar to that observed in behavioural variant frontotemporal dementia (bvFTD). In the current study, we compared neurocognitive performance …
Previous research has suggested that the pattern and severity of cognitive deficits in people with severe chronic schizophrenia is similar t …
Clinical effectiveness of metacognitive training as a transdiagnostic program in routine clinical settings: A prospective, multicenter, single-group study.
Tanoue H, Yoshinaga N, Hayashi Y, Ishikawa R, Ishigaki T, Ishida Y. Tanoue H, et al. Jpn J Nurs Sci. 2021 Apr;18(2):e12389. doi: 10.1111/jjns.12389. Epub 2020 Nov 11. Jpn J Nurs Sci. 2021. PMID: 33174673 Clinical Trial.
RESULTS: Thirty-four participants enrolled in the study and received MCT (schizophrenia = 22, non-schizophrenia = 12). Intent-to-treat analyses revealed significant improvements in quality of life/global functioning during the intervention period, and further improv …
RESULTS: Thirty-four participants enrolled in the study and received MCT (schizophrenia = 22, non-schizophrenia = 12). Intent- …
ZO-1 Serum Levels as a Potential Biomarker for Psychotic Disorder.
Aydogan Avşar P, Akkuş M. Aydogan Avşar P, et al. Clin Neuropharmacol. 2024 May-Jun 01;47(3):67-71. doi: 10.1097/WNF.0000000000000590. Clin Neuropharmacol. 2024. PMID: 38743599
The aim of this study was to investigate the role of changes in serum ZO-1 concentrations in the etiopathogenesis of patients with schizophrenia. METHODS: A total of 46 patients, 34 with schizophrenia, 12 with a first psychotic attack, and 37 healthy controls, were …
The aim of this study was to investigate the role of changes in serum ZO-1 concentrations in the etiopathogenesis of patients with schizophr …
Long-term safety and effectiveness of lurasidone in schizophrenia: a 22-month, open-label extension study.
Correll CU, Cucchiaro J, Silva R, Hsu J, Pikalov A, Loebel A. Correll CU, et al. CNS Spectr. 2016 Oct;21(5):393-402. doi: 10.1017/S1092852915000917. Epub 2016 Apr 6. CNS Spectr. 2016. PMID: 27048911
Change in the Positive and Negative Syndrome Scale (PANSS) was analyzed using both observed case (OC) and last observation carried forward (LOCF) analyses. ...Thirty-seven patients (14.7%) discontinued due to an adverse event (AE) during OL treatment. Three AEs occu …
Change in the Positive and Negative Syndrome Scale (PANSS) was analyzed using both observed case (OC) and last observation car …
Transition to schizophrenia in acute and transient psychotic disorders.
Queirazza F, Semple DM, Lawrie SM. Queirazza F, et al. Br J Psychiatry. 2014;204:299-305. doi: 10.1192/bjp.bp.113.127340. Epub 2013 Dec 19. Br J Psychiatry. 2014. PMID: 24357576
Diagnostic stability was estimated at 53.9% over an average of approximately 4 years of observation. The most common diagnostic shift was to schizophrenia (12.6%), over an average of 1.7 years. ...
Diagnostic stability was estimated at 53.9% over an average of approximately 4 years of observation. The most common diagnostic shift …
Drug attitude and other predictors of medication adherence in schizophrenia: 12 months of electronic monitoring (MEMS()) in the Swedish COAST-study.
Brain C, Allerby K, Sameby B, Quinlan P, Joas E, Karilampi U, Lindström E, Eberhard J, Burns T, Waern M. Brain C, et al. Eur Neuropsychopharmacol. 2013 Dec;23(12):1754-62. doi: 10.1016/j.euroneuro.2013.09.001. Epub 2013 Sep 19. Eur Neuropsychopharmacol. 2013. PMID: 24091164
A slightly modified DAI-10 version for informants was distributed as a postal questionnaire. Non-adherence (MEMS() adherence 0.80) was observed in 27%. In univariate regression models low scores on DAI-10 and DAI-10 informant, higher positive symptom burden, poor fu …
A slightly modified DAI-10 version for informants was distributed as a postal questionnaire. Non-adherence (MEMS() adherence 0.80) was ob
Correlations of premorbid adjustment in schizophrenia with auditory event-related potential and neuropsychological abnormalities.
Levitt JJ, O'Donnell BF, McCarley RW, Nestor PG, Shenton ME. Levitt JJ, et al. Am J Psychiatry. 1996 Oct;153(10):1347-9. doi: 10.1176/ajp.153.10.1347. Am J Psychiatry. 1996. PMID: 8831448
OBJECTIVE: The authors examined the relationship between premorbid adjustment in schizophrenia and event-related potential data and neuropsychological data obtained after onset of the illness. METHOD: They interviewed 13 male veterans with chronic schizophrenia, 12
OBJECTIVE: The authors examined the relationship between premorbid adjustment in schizophrenia and event-related potential data and neuropsy …
Brain-derived neurotrophic factor as a biomarker for cognitive recovery in acute schizophrenia: 12-week results from a prospective longitudinal study.
Zhang Y, Fang X, Fan W, Tang W, Cai J, Song L, Zhang C. Zhang Y, et al. Psychopharmacology (Berl). 2018 Apr;235(4):1191-1198. doi: 10.1007/s00213-018-4835-6. Epub 2018 Feb 1. Psychopharmacology (Berl). 2018. PMID: 29392373

A significantly decreased plasma level of BDNF in patients was observed compared with the controls (F = 7.77, P = 0.006). A significant improvement in each PANSS subscore and total score was observed when the patients completed this study (Ps < 0.01). ...S

A significantly decreased plasma level of BDNF in patients was observed compared with the controls (F = 7.77, P = 0.006). A significa …
21 results