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890 results

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Quoted phrase not found in phrase index: "Sensitivity to genotoxic agents"
Page 1
The comet assay for DNA damage and repair: principles, applications, and limitations.
Collins AR. Collins AR. Mol Biotechnol. 2004 Mar;26(3):249-61. doi: 10.1385/MB:26:3:249. Mol Biotechnol. 2004. PMID: 15004294 Review.
The assay has applications in testing novel chemicals for genotoxicity, monitoring environmental contamination with genotoxins, human biomonitoring and molecular epidemiology, and fundamental research in DNA damage and repair. The sensitivity and specifici …
The assay has applications in testing novel chemicals for genotoxicity, monitoring environmental contamination with genotoxins, human …
N-acetyl-l-cysteine.
De Vries N, De Flora S. De Vries N, et al. J Cell Biochem Suppl. 1993;17F:270-7. doi: 10.1002/jcb.240531040. J Cell Biochem Suppl. 1993. PMID: 8412205 Review.
One of the few chemopreventive agents not in this group and presently being used in a clinical trial is N-acetyl-l-cysteine (NAC). ...NAC has also demonstrated an effect on mutagen-induced chromosomal sensitivity assays, and on anticarcinogenicity in experimental an …
One of the few chemopreventive agents not in this group and presently being used in a clinical trial is N-acetyl-l-cysteine (NAC). .. …
Is metronidazole carcinogenic?
Bendesky A, Menéndez D, Ostrosky-Wegman P. Bendesky A, et al. Mutat Res. 2002 Jun;511(2):133-44. doi: 10.1016/s1383-5742(02)00007-8. Mutat Res. 2002. PMID: 12052431 Review.
As it will be discussed here, the existing population studies are deficient since they have not included sufficient sample size, the follow-up time has not been long enough, and the individual sensitivity to the drug might have been acting as a confounding factor. Due to t …
As it will be discussed here, the existing population studies are deficient since they have not included sufficient sample size, the follow- …
Chromosomal aberrations, clastogens vs aneugens.
Mishima M. Mishima M. Front Biosci (Schol Ed). 2017 Jan 1;9(1):1-16. doi: 10.2741/s468. Front Biosci (Schol Ed). 2017. PMID: 27814570 Free article. Review.
Current anticancer therapy may be one of the most important exogenous sources of exposure to genotoxic agents in US, Japan, and Europe, where approximately 40-55 percent of the population is diagnosed with cancer at a certain point in their life. ...The emerging bio …
Current anticancer therapy may be one of the most important exogenous sources of exposure to genotoxic agents in US, Japan, an …
Chemotherapeutic drugs induced female reproductive toxicity and treatment strategies.
Bhardwaj JK, Bikal P, Sachdeva SN. Bhardwaj JK, et al. J Biochem Mol Toxicol. 2023 Jul;37(7):e23371. doi: 10.1002/jbt.23371. Epub 2023 Apr 26. J Biochem Mol Toxicol. 2023. PMID: 37098697 Review.
With the declining cancer mortality, however, the cancer survivors are also subjected to the adverse consequences of chemotherapy, particularly in the female reproductive system. Recent studies have shown the sensitivity of the ovarian tissue to the chemotherapeutic drugs- …
With the declining cancer mortality, however, the cancer survivors are also subjected to the adverse consequences of chemotherapy, particula …
Comet assay in ecogenotoxicology: Applications in Mytilus sp.
Bolognesi C, Cirillo S, Chipman JK. Bolognesi C, et al. Mutat Res Genet Toxicol Environ Mutagen. 2019 Jun;842:50-59. doi: 10.1016/j.mrgentox.2019.05.004. Epub 2019 May 8. Mutat Res Genet Toxicol Environ Mutagen. 2019. PMID: 31255226 Review.
The comet assay is a sensitive technique to detect DNA damage caused by exposure to genotoxic chemical and physical agents and is widely used in ecotoxicology. ...Twenty-nine laboratory studies were retrieved showing the sensitivity of the comet assay …
The comet assay is a sensitive technique to detect DNA damage caused by exposure to genotoxic chemical and physical agents …
Factors Affecting the Nuclei in Newborn and Children.
Arnaoutoglou C, Keivanidou A, Dragoutsos G, Tentas I, Meditskou S, Zarogoulidis P, Matthaios D, Sardeli C, Ioannidis A, Perdikouri EI, Giannopoulos A. Arnaoutoglou C, et al. Int J Environ Res Public Health. 2022 Apr 1;19(7):4226. doi: 10.3390/ijerph19074226. Int J Environ Res Public Health. 2022. PMID: 35409906 Free PMC article. Review.
It is known that children are more sensitive to the effects of medical treatments and environment than adults. Today there is limited information regarding the differences in genotoxic effects in children. The micronucleus assay is a method that is used to monitor …
It is known that children are more sensitive to the effects of medical treatments and environment than adults. Today there is limited …
Sensitivity of Neuroblastoma and Induced Neural Progenitor Cells to High-Intensity THz Radiation.
Sitnikov D, Revkova V, Ilina I, Shatalova R, Komarov P, Struleva E, Konoplyannikov M, Kalsin V, Baklaushev V. Sitnikov D, et al. Int J Mol Sci. 2023 Mar 31;24(7):6558. doi: 10.3390/ijms24076558. Int J Mol Sci. 2023. PMID: 37047534 Free PMC article.
The results demonstrated that the exposure of non-tumor and tumor cells to broadband (0.1-3 THz) THz pulses with the intensity of 21 GW/cm(2) and the electric field strength of 2.8 MV/cm for 30 min induced neither a noticeable genotoxic effect nor a statistically significa …
The results demonstrated that the exposure of non-tumor and tumor cells to broadband (0.1-3 THz) THz pulses with the intensity of 21 GW/cm(2 …
T-2 mycotoxin: toxicological effects and decontamination strategies.
Adhikari M, Negi B, Kaushik N, Adhikari A, Al-Khedhairy AA, Kaushik NK, Choi EH. Adhikari M, et al. Oncotarget. 2017 May 16;8(20):33933-33952. doi: 10.18632/oncotarget.15422. Oncotarget. 2017. PMID: 28430618 Free PMC article. Review.
Trichothecene is hazardously intoxicating due to their additional potential to be topically absorbed, and their metabolites affect the gastrointestinal tract, skin, kidney, liver, and immune and hematopoietic progenitor cellular systems. Sensitivity to this type of toxin v …
Trichothecene is hazardously intoxicating due to their additional potential to be topically absorbed, and their metabolites affect the gastr …
Short Assay Design for Micronucleus Detection in Human Lymphocytes.
Rincón G, Sánchez C. Rincón G, et al. Biomed Res Int. 2021 Sep 11;2021:2322257. doi: 10.1155/2021/2322257. eCollection 2021. Biomed Res Int. 2021. PMID: 34552982 Free PMC article. Review.
There has been a constant need to develop new and faster cytogenetic assays to measure the instability induced by genotoxic agents in the field of cytogenetic research, an example of which is the micronucleus assay. Micronuclei are fragments or complete chromosomes …
There has been a constant need to develop new and faster cytogenetic assays to measure the instability induced by genotoxic agents …
890 results