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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1965 9
1966 15
1967 18
1968 25
1969 41
1970 38
1971 35
1972 26
1973 47
1974 37
1975 25
1976 27
1977 15
1978 17
1979 24
1980 25
1981 60
1982 80
1983 60
1984 70
1985 75
1986 50
1987 41
1988 56
1989 73
1990 72
1991 91
1992 93
1993 124
1994 104
1995 119
1996 111
1997 120
1998 143
1999 112
2000 147
2001 146
2002 157
2003 188
2004 223
2005 214
2006 259
2007 249
2008 270
2009 266
2010 305
2011 330
2012 339
2013 385
2014 419
2015 410
2016 436
2017 514
2018 559
2019 600
2020 600
2021 545
2022 463
2023 439
2024 197

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9,749 results

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Page 1
Fluid Therapy for Critically Ill Adults With Sepsis: A Review.
Zampieri FG, Bagshaw SM, Semler MW. Zampieri FG, et al. JAMA. 2023 Jun 13;329(22):1967-1980. doi: 10.1001/jama.2023.7560. JAMA. 2023. PMID: 37314271 Review.
Among 3723 patients with sepsis who received 1 to 2 L of fluid, 3 randomized clinical trials (RCTs) reported that goal-directed therapy administering fluid boluses to attain a central venous pressure of 8 to 12 mm Hg, vasopressors to attain a mean arterial blood pre …
Among 3723 patients with sepsis who received 1 to 2 L of fluid, 3 randomized clinical trials (RCTs) reported that goal-directe …
International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics.
Goldstein B, Giroir B, Randolph A; International Consensus Conference on Pediatric Sepsis. Goldstein B, et al. Pediatr Crit Care Med. 2005 Jan;6(1):2-8. doi: 10.1097/01.PCC.0000149131.72248.E6. Pediatr Crit Care Med. 2005. PMID: 15636651 Review.
b) What are the specific definitions of pediatric SIRS, infection, sepsis, severe sepsis, and septic shock? c) What are the specific definitions of pediatric organ failure and the validity of pediatric organ failure scores? ...CONCLUSION: We modified the adult SIRS …
b) What are the specific definitions of pediatric SIRS, infection, sepsis, severe sepsis, and septic shock? c) What are the sp …
Septic Shock: Advances in Diagnosis and Treatment.
Seymour CW, Rosengart MR. Seymour CW, et al. JAMA. 2015 Aug 18;314(7):708-17. doi: 10.1001/jama.2015.7885. JAMA. 2015. PMID: 26284722 Free PMC article. Review.
IMPORTANCE: Septic shock is a clinical emergency that occurs in more than 230,000 US patients each year. ...Focused ultrasonography is recommended for the prompt recognition of complicating physiology (eg, hypovolemia or cardiogenic shock), while invasive hem …
IMPORTANCE: Septic shock is a clinical emergency that occurs in more than 230,000 US patients each year. ...Focused ult …
Severe Sepsis and Septic Shock Trials (ProCESS, ARISE, ProMISe): What is Optimal Resuscitation?
Osborn TM. Osborn TM. Crit Care Clin. 2017 Apr;33(2):323-344. doi: 10.1016/j.ccc.2016.12.004. Crit Care Clin. 2017. PMID: 28284298 Review.
Between 2014 and 2015, 3 independent, multicenter, randomized controlled trials evaluated early goal-directed therapy (EGDT) in severe sepsis and septic shock: Protocolized Care for Early Septic Shock (ProCESS) from the United States; Australasi …
Between 2014 and 2015, 3 independent, multicenter, randomized controlled trials evaluated early goal-directed therapy (EGDT) in sever …
Hemodynamic phenotype-based, capillary refill time-targeted resuscitation in early septic shock: The ANDROMEDA-SHOCK-2 Randomized Clinical Trial study protocol.
Kattan E, Bakker J, Estenssoro E, Ospina-Tascón GA, Cavalcanti AB, Backer D, Vieillard-Baron A, Teboul JL, Castro R, Hernández G. Kattan E, et al. Rev Bras Ter Intensiva. 2022 Jan-Mar;34(1):96-106. doi: 10.5935/0103-507X.20220004-pt. Rev Bras Ter Intensiva. 2022. PMID: 35766659 Free PMC article.
BACKGROUND: Early reversion of sepsis-induced tissue hypoperfusion is essential for survival in septic shock. However, consensus regarding the best initial resuscitation strategy is lacking given that interventions designed for the entire population with septic …
BACKGROUND: Early reversion of sepsis-induced tissue hypoperfusion is essential for survival in septic shock. However, consens …
Safety of the Peripheral Administration of Vasopressor Agents.
Lewis T, Merchan C, Altshuler D, Papadopoulos J. Lewis T, et al. J Intensive Care Med. 2019 Jan;34(1):26-33. doi: 10.1177/0885066616686035. Epub 2017 Jan 11. J Intensive Care Med. 2019. PMID: 28073314
Vasopressors are an integral component of the management of septic shock and are traditionally given via a central venous catheter (CVC) due to the risk of tissue injury and necrosis if extravasated. However, the need for a CVC for the management of septic …
Vasopressors are an integral component of the management of septic shock and are traditionally given via a central venous cath …
Macrophage Activation-Like Syndrome: A Distinct Entity Leading to Early Death in Sepsis.
Karakike E, Giamarellos-Bourboulis EJ. Karakike E, et al. Front Immunol. 2019 Jan 31;10:55. doi: 10.3389/fimmu.2019.00055. eCollection 2019. Front Immunol. 2019. PMID: 30766533 Free PMC article. Review.
There are 10 on-going trials in adults with sHLH; two for the development of biomarkers and eight for management. Only one of them is focusing in sepsis. The acronym of the trial is PROVIDE (ClinicalTrials.gov NCT03332225) and it is a double-blind randomized clin …
There are 10 on-going trials in adults with sHLH; two for the development of biomarkers and eight for management. Only one of them is focusi …
The SOFA score-development, utility and challenges of accurate assessment in clinical trials.
Lambden S, Laterre PF, Levy MM, Francois B. Lambden S, et al. Crit Care. 2019 Nov 27;23(1):374. doi: 10.1186/s13054-019-2663-7. Crit Care. 2019. PMID: 31775846 Free PMC article. Review.
In addition, it proposes guidance designed to facilitate the consistent and valid assessment of the score in multicentre sepsis trials involving novel therapeutic agents or interventions.ConclusionThe SOFA score is an increasingly important tool in defining both the clinical …
In addition, it proposes guidance designed to facilitate the consistent and valid assessment of the score in multicentre sepsis trials invol …
Low-dose corticosteroids for adult patients with septic shock: a systematic review with meta-analysis and trial sequential analysis.
Rygård SL, Butler E, Granholm A, Møller MH, Cohen J, Finfer S, Perner A, Myburgh J, Venkatesh B, Delaney A. Rygård SL, et al. Intensive Care Med. 2018 Jul;44(7):1003-1016. doi: 10.1007/s00134-018-5197-6. Epub 2018 May 14. Intensive Care Med. 2018. PMID: 29761216 Review.
PURPOSE: To assess the effect of low dose corticosteroids on outcomes in adults with septic shock. METHODS: We systematically reviewed randomised clinical trials (RCTs) comparing low-dose corticosteroids to placebo in adults with septic shock …
PURPOSE: To assess the effect of low dose corticosteroids on outcomes in adults with septic shock. METHODS: We systematically …
Different Concentrations of Albumin Versus Crystalloid in Patients with Sepsis and Septic Shock: A Meta-Analysis of Randomized Clinical Trials.
Geng L, Tian X, Gao Z, Mao A, Feng L, He C. Geng L, et al. J Intensive Care Med. 2023 Aug;38(8):679-689. doi: 10.1177/08850666231170778. Epub 2023 Apr 20. J Intensive Care Med. 2023. PMID: 37078161 Review.
MATERIALS AND METHODS: PubMed, EMBASE, and Web of Science databases were used for screening the relevant studies. Randomized controlled trials (RCTs) were eligible if they compared the effects of albumin with crystalloid on mortality in patients with sepsis and septic …
MATERIALS AND METHODS: PubMed, EMBASE, and Web of Science databases were used for screening the relevant studies. Randomized controll …
9,749 results