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Page 1
Mortality in sickle cell disease. Life expectancy and risk factors for early death.
Platt OS, Brambilla DJ, Rosse WF, Milner PF, Castro O, Steinberg MH, Klug PP. Platt OS, et al. N Engl J Med. 1994 Jun 9;330(23):1639-44. doi: 10.1056/NEJM199406093302303. N Engl J Med. 1994. PMID: 7993409 Free article.
Early mortality was highest among patients whose disease was symptomatic. A high level of fetal hemoglobin predicted improved survival and is probably a reliable childhood forecaster of adult life expectancy....
Early mortality was highest among patients whose disease was symptomatic. A high level of fetal hemoglobin predicted improved surviva …
Clinical presentation of sickle cell-hemoglobin C disease.
Williams S, Maude GH, Serjeant GR. Williams S, et al. J Pediatr. 1986 Oct;109(4):586-9. doi: 10.1016/s0022-3476(86)80217-7. J Pediatr. 1986. PMID: 3761071
The commonest nonspecific symptom was acute chest syndrome. The relatively mild early clinical course of sickle cell-hemoglobin C disease indicates that neonatal diagnosis does not have the same urgency as for homozygous sickle cell disease....
The commonest nonspecific symptom was acute chest syndrome. The relatively mild early clinical course of sickle cell-hemoglobin C dis …
Pitted red cell counts in sickle cell disease. Relationship to age, hemoglobin genotype, and splenic size.
Fatunde OJ, Scott RB. Fatunde OJ, et al. Am J Pediatr Hematol Oncol. 1986 Winter;8(4):329-33. doi: 10.1097/00043426-198624000-00011. Am J Pediatr Hematol Oncol. 1986. PMID: 3799933
In both HbSS and HbSC patients, the pit count was significantly lower in patients who had palpable spleens. The pit count may be used as a predictor of disease severity in the sickle cell disorders....
In both HbSS and HbSC patients, the pit count was significantly lower in patients who had palpable spleens. The pit count may be used as a …
Acute splenic complications in children with sickle cell-hemoglobin C disease.
Aquino VM, Norvell JM, Buchanan GR. Aquino VM, et al. J Pediatr. 1997 Jun;130(6):961-5. doi: 10.1016/s0022-3476(97)70284-1. J Pediatr. 1997. PMID: 9202620
CONCLUSIONS: We conclude that (1) acute splenic complications in children and adolescents with SC disease are relatively uncommon, (2) most episodes of ASSC occur in preadolescents, (3) ASSC can be life threatening, even in younger children, and (4) prior splenomegaly is not a go …
CONCLUSIONS: We conclude that (1) acute splenic complications in children and adolescents with SC disease are relatively uncommon, (2) most …
Red cell life span in sickle cell-hemoglobin C disease with a note about sickle cell-hemoglobin O ARAB.
McCurdy PR, Mahmood L, Sherman AS. McCurdy PR, et al. Blood. 1975 Feb;45(2):273-9. Blood. 1975. PMID: 1120186 Free article.
Red cell volume was slightly reduced in most patients (87% plus or minus 20% of predicted normal). In nine SC patients, mean red cell life (DF32p) was 28.9 plus or minus 4.0 days. ...
Red cell volume was slightly reduced in most patients (87% plus or minus 20% of predicted normal). In nine SC patients, mean red cell …
High-dose intravenous methylprednisolone therapy for pain in children and adolescents with sickle cell disease.
Griffin TC, McIntire D, Buchanan GR. Griffin TC, et al. N Engl J Med. 1994 Mar 17;330(11):733-7. doi: 10.1056/NEJM199403173301101. N Engl J Med. 1994. PMID: 8107739 Free article. Clinical Trial.
No adverse effects of methylprednisolone were observed. CONCLUSIONS: A short course of high-dose methylprednisolone decreased the duration of severe pain in children and adolescents with sickle cell disease, but patients who received methylprednisolone had more rebound att …
No adverse effects of methylprednisolone were observed. CONCLUSIONS: A short course of high-dose methylprednisolone decreased the dur …
13 results