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Sodium Zirconium Cyclosilicate.
[No authors listed] [No authors listed] 2023 Feb 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2023 Feb 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30694621 Free Books & Documents. Review.
Because sodium zirconium cyclosilicate is not orally absorbed it is unlikely to reach the breastmilk or adversely affect the breastfed infant. ...
Because sodium zirconium cyclosilicate is not orally absorbed it is unlikely to reach the breastmilk or adversely affec …
Sodium Zirconium Cyclosilicate.
Levien TL, Baker DE. Levien TL, et al. Hosp Pharm. 2019 Feb;54(1):12-19. doi: 10.1177/0018578718817470. Epub 2018 Dec 14. Hosp Pharm. 2019. PMID: 30718929 Free PMC article. Review.
Sodium zirconium cyclosilicate in hyperkalemia.
Packham DK, Rasmussen HS, Lavin PT, El-Shahawy MA, Roger SD, Block G, Qunibi W, Pergola P, Singh B. Packham DK, et al. N Engl J Med. 2015 Jan 15;372(3):222-31. doi: 10.1056/NEJMoa1411487. Epub 2014 Nov 21. N Engl J Med. 2015. PMID: 25415807 Free article. Clinical Trial.
BACKGROUND: Hyperkalemia (serum potassium level, >5.0 mmol per liter) is associated with increased mortality among patients with heart failure, chronic kidney disease, or diabetes. We investigated whether sodium zirconium cyclosilicate (ZS-9), a novel sele …
BACKGROUND: Hyperkalemia (serum potassium level, >5.0 mmol per liter) is associated with increased mortality among patients with heart fa …
Sodium Zirconium Cyclosilicate among Individuals with Hyperkalemia: A 12-Month Phase 3 Study.
Spinowitz BS, Fishbane S, Pergola PE, Roger SD, Lerma EV, Butler J, von Haehling S, Adler SH, Zhao J, Singh B, Lavin PT, McCullough PA, Kosiborod M, Packham DK; ZS-005 Study Investigators. Spinowitz BS, et al. Clin J Am Soc Nephrol. 2019 Jun 7;14(6):798-809. doi: 10.2215/CJN.12651018. Epub 2019 May 20. Clin J Am Soc Nephrol. 2019. PMID: 31110051 Free PMC article.
BACKGROUND AND OBJECTIVES: Oral sodium zirconium cyclosilicate (formerly ZS-9) binds and removes potassium via the gastrointestinal tract. ...Participants were predominantly white, men, and age 65 years old; 74% had an eGFR<60 ml/min per 1.73 m(2), and 65% …
BACKGROUND AND OBJECTIVES: Oral sodium zirconium cyclosilicate (formerly ZS-9) binds and removes potassium via the gast …
Effect of sodium zirconium cyclosilicate on potassium lowering for 28 days among outpatients with hyperkalemia: the HARMONIZE randomized clinical trial.
Kosiborod M, Rasmussen HS, Lavin P, Qunibi WY, Spinowitz B, Packham D, Roger SD, Yang A, Lerma E, Singh B. Kosiborod M, et al. JAMA. 2014 Dec 3;312(21):2223-33. doi: 10.1001/jama.2014.15688. JAMA. 2014. PMID: 25402495 Clinical Trial.
IMPORTANCE: Hyperkalemia is a common electrolyte abnormality that may be difficult to manage because of a lack of effective therapies. Sodium zirconium cyclosilicate is a nonabsorbed cation exchanger that selectively binds potassium in the intestine. ...CONCL …
IMPORTANCE: Hyperkalemia is a common electrolyte abnormality that may be difficult to manage because of a lack of effective therapies. So …
Patiromer and Sodium Zirconium Cyclosilicate in Treatment of Hyperkalemia: A Systematic Review and Meta-Analysis.
Shrestha DB, Budhathoki P, Sedhai YR, Baniya R, Cable CA, Kashiouris MG, Dixon DL, Kidd JM, Adhikari Y, Marasini A, Bhandari S. Shrestha DB, et al. Curr Ther Res Clin Exp. 2021 Jul 5;95:100635. doi: 10.1016/j.curtheres.2021.100635. eCollection 2021. Curr Ther Res Clin Exp. 2021. PMID: 34367383 Free PMC article. Review.
BACKGROUND: Patiromer and sodium zirconium cyclosilicate (SZC) are newer options for hyperkalemia treatment. ...
BACKGROUND: Patiromer and sodium zirconium cyclosilicate (SZC) are newer options for hyperkalemia treatment. ...
Sodium Zirconium Cyclosilicate: A Review in Hyperkalaemia.
Hoy SM. Hoy SM. Drugs. 2018 Oct;78(15):1605-1613. doi: 10.1007/s40265-018-0991-6. Drugs. 2018. PMID: 30306338 Free PMC article. Review.
Sodium zirconium cyclosilicate (Lokelma) [hereafter referred to as SZC] is a non-absorbed, non-polymer zirconium silicate compound that preferentially exchanges hydrogen and sodium for potassium and ammonium ions in the gastrointestinal tract (GIT), thereby i …
Sodium zirconium cyclosilicate (Lokelma) [hereafter referred to as SZC] is a non-absorbed, non-polymer zirconium silica …
Sodium zirconium cyclosilicate and metabolic acidosis: Potential mechanisms and clinical consequences.
Fernandez-Prado R, Villalvazo P, Avello A, Gonzalez-de-Rivera M, Aguirre M, Carrasco-Muñoz CG, Fernandez-Fernandez B, Martin-Cleary C, Carriazo S, Sanchez-Niño MD, Perez-Gomez MV, Ortiz A. Fernandez-Prado R, et al. Biomed Pharmacother. 2023 Feb;158:114197. doi: 10.1016/j.biopha.2022.114197. Epub 2023 Jan 4. Biomed Pharmacother. 2023. PMID: 36916426 Free article. Review.
Clinical guidelines recommend a target serum bicarbonate 22 mmol/L, but metabolic acidosis frequently remains undiagnosed and untreated. Sodium zirconium cyclosilicate (SZC) binds potassium in the gut and is approved to treat hyperkalemia. ...
Clinical guidelines recommend a target serum bicarbonate 22 mmol/L, but metabolic acidosis frequently remains undiagnosed and untreated. …
Sodium zirconium cyclosilicate for the management of chronic hyperkalemia in kidney disease, a novel agent.
Rastogi A, Hanna RM, Mkrttchyan A, Khalid M, Yaqoob S, Shaffer K, Dhawan P, Nobakht N, Kamgar M, Goshtaseb R, Sarmosyan K, Gnarini M, Wassef O, Lerma E. Rastogi A, et al. Expert Rev Clin Pharmacol. 2021 Sep;14(9):1055-1064. doi: 10.1080/17512433.2021.1932460. Epub 2021 Jul 6. Expert Rev Clin Pharmacol. 2021. PMID: 34227913 Review.
The concern of gastrointestinal (GI) adverse effects with sodium polystyrene sulfonate has spurred the development of alternatives. Sodium zirconium cyclosilicate (SZC) is a promising agent that selectively binds potassium in the gut and eliminates it, while …
The concern of gastrointestinal (GI) adverse effects with sodium polystyrene sulfonate has spurred the development of alternatives. Sodiu …
230 results