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Quoted phrase not found in phrase index: "Spermatogenic failure 12"
Page 1
Genetic Architecture of Azoospermia-Time to Advance the Standard of Care.
Wyrwoll MJ, Köckerling N, Vockel M, Dicke AK, Rotte N, Pohl E, Emich J, Wöste M, Ruckert C, Wabschke R, Seggewiss J, Ledig S, Tewes AC, Stratis Y, Cremers JF, Wistuba J, Krallmann C, Kliesch S, Röpke A, Stallmeyer B, Friedrich C, Tüttelmann F. Wyrwoll MJ, et al. Eur Urol. 2023 May;83(5):452-462. doi: 10.1016/j.eururo.2022.05.011. Epub 2022 Jun 8. Eur Urol. 2023. PMID: 35690514
BACKGROUND: Crypto- and azoospermia (very few/no sperm in the semen) are main contributors to male factor infertility. Genetic causes for spermatogenic failure (SPGF) include Klinefelter syndrome and Y-chromosomal azoospermia factor microdeletions, and CFTR mutation …
BACKGROUND: Crypto- and azoospermia (very few/no sperm in the semen) are main contributors to male factor infertility. Genetic causes for …
Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis.
Radaelli E, Assenmacher CA, Verrelle J, Banerjee E, Manero F, Khiati S, Girona A, Lopez-Lluch G, Navas P, Spinazzi M. Radaelli E, et al. Elife. 2023 Jul 28;12:e84710. doi: 10.7554/eLife.84710. Elife. 2023. PMID: 37505079 Free PMC article.
Interestingly, genetic modifications of PINK1, PGAM5, and TTC19 - three major substrates of PARL with important roles in mitochondrial homeostasis - fail to reproduce or modify this severe phenotype, indicating that the spermatogenic arrest arises from distinct molecular p …
Interestingly, genetic modifications of PINK1, PGAM5, and TTC19 - three major substrates of PARL with important roles in mitochondrial homeo …
Monogenic causes of non-obstructive azoospermia: challenges, established knowledge, limitations and perspectives.
Kasak L, Laan M. Kasak L, et al. Hum Genet. 2021 Jan;140(1):135-154. doi: 10.1007/s00439-020-02112-y. Epub 2020 Jan 18. Hum Genet. 2021. PMID: 31955275 Review.
Non-obstructive azoospermia (NOA) is mostly explained by congenital factors leading to spermatogenic failure, such as chromosome abnormalities. The knowledge of the monogenic causes of NOA is very limited. ...Uncovering the loci and biological processes implicated i …
Non-obstructive azoospermia (NOA) is mostly explained by congenital factors leading to spermatogenic failure, such as chromoso …
Predictors of surgical sperm retrieval in non-obstructive azoospermia: summary of current literature.
Arshad MA, Majzoub A, Esteves SC. Arshad MA, et al. Int Urol Nephrol. 2020 Nov;52(11):2015-2038. doi: 10.1007/s11255-020-02529-4. Epub 2020 Jun 9. Int Urol Nephrol. 2020. PMID: 32519242 Review.
Given the variability in clinical presentation, the potential role of factors that can predict the likelihood of successful testicular SR needs to be clarified. This article summarizes the current evidence concerning the variables predicting SR success in non-obstru …
Given the variability in clinical presentation, the potential role of factors that can predict the likelihood of successful testicula …
Microdeletions and microduplications linked to severe congenital disorders in infertile men.
Kikas T, Punab AM, Kasak L, Poolamets O, Vihljajev V, Pomm K, Reiman M, Tjagur S, Korrovits P, Punab M, Laan M. Kikas T, et al. Sci Rep. 2023 Jan 11;13(1):574. doi: 10.1038/s41598-023-27750-w. Sci Rep. 2023. PMID: 36631630 Free PMC article.
Data on the clinical validity of DNA copy number variants (CNVs) in spermatogenic failure (SPGF) is limited. This study analyzed the genome-wide CNV profile in 215 men with idiopathic SPGF and 62 normozoospermic fertile men, recruited at the Andrology Clinic, Tartu …
Data on the clinical validity of DNA copy number variants (CNVs) in spermatogenic failure (SPGF) is limited. This study analyz …
Variants in GCNA, X-linked germ-cell genome integrity gene, identified in men with primary spermatogenic failure.
Hardy JJ, Wyrwoll MJ, Mcfadden W, Malcher A, Rotte N, Pollock NC, Munyoki S, Veroli MV, Houston BJ, Xavier MJ, Kasak L, Punab M, Laan M, Kliesch S, Schlegel P, Jaffe T, Hwang K, Vukina J, Brieño-Enríquez MA, Orwig K, Yanowitz J, Buszczak M, Veltman JA, Oud M, Nagirnaja L, Olszewska M, O'Bryan MK, Conrad DF, Kurpisz M, Tüttelmann F, Yatsenko AN; GEMINI Consortium. Hardy JJ, et al. Hum Genet. 2021 Aug;140(8):1169-1182. doi: 10.1007/s00439-021-02287-y. Epub 2021 May 7. Hum Genet. 2021. PMID: 33963445 Free PMC article.
A critical element of successful spermatogenesis is maintenance of genome integrity. Here, we present a genomic study of spermatogenic failure (SPGF). Our initial analysis (n = 176) did not reveal known gene-candidates but identified a potentially significant single …
A critical element of successful spermatogenesis is maintenance of genome integrity. Here, we present a genomic study of spermatogenic …
Stem Cell Factor Receptor Immunoexpression in Adolescent Varicocele.
Arena S, Impellizzeri P, Fazzari C, Peri Flora M, Enrica A, Calabrese U, Centorrino A, Alibrandi A, Romeo C. Arena S, et al. Urol J. 2020 Jun 23;17(4):391-396. doi: 10.22037/uj.v0i0.5351. Urol J. 2020. PMID: 32207142 Free article.
The relationship between percentage of testicular asymmetry, number of tubular c-kit positive germ cells and severity of spermatogenic failure was assessed. RESULTS: The mean (SD; median) histological grade for spermatogenic failure in controls was 1.3 …
The relationship between percentage of testicular asymmetry, number of tubular c-kit positive germ cells and severity of spermatogenic …
DAX-1 and DAX-1A expression in human testicular tissues with primary spermatogenic failure.
Lardone MC, Parada-Bustamante A, Ebensperger M, Valdevenito R, Kakarieka E, Martínez D, Pommer R, Piottante A, Castro A. Lardone MC, et al. Mol Hum Reprod. 2011 Dec;17(12):739-46. doi: 10.1093/molehr/gar051. Epub 2011 Jul 20. Mol Hum Reprod. 2011. PMID: 21775412
We aimed to study the mRNA and protein expression of DAX-1 in testicular tissues of 65 men with primary spermatogenic failure [complete Sertoli cell only syndrome (SCOS), focal SCOS, maturation arrest and mixed atrophy] compared with 33 controls with normal spermato …
We aimed to study the mRNA and protein expression of DAX-1 in testicular tissues of 65 men with primary spermatogenic failure …
Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern Humans.
Glinsky GV. Glinsky GV. Mol Genet Genomics. 2022 Nov;297(6):1711-1740. doi: 10.1007/s00438-022-01954-7. Epub 2022 Sep 19. Mol Genet Genomics. 2022. PMID: 36121513 Free PMC article.
Unexpectedly, HS-LTRs manifest regulatory connectivity to genes encoding markers of 12 distinct cells' populations of fetal gonads, as well as genes implicated in physiology and pathology of human spermatogenesis, including Y-linked spermatogenic failure, oli …
Unexpectedly, HS-LTRs manifest regulatory connectivity to genes encoding markers of 12 distinct cells' populations of fetal gonads, a …
Outcomes of partial intussusception and endo-to-side vasoepididymostomy in men with epididymal obstructive azoospermia.
Shiraishi K, Matsuyama H. Shiraishi K, et al. Int J Urol. 2020 Dec;27(12):1124-1129. doi: 10.1111/iju.14368. Epub 2020 Sep 11. Int J Urol. 2020. PMID: 32914440

Johnsen score count and proliferating cell nuclear antigen expression were used as surrogates for spermatogenic function. ...Multivariate analyses showed that the presence of motile sperm in the epididymis and a higher spermatogenic function (P < 0.05) wer

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Johnsen score count and proliferating cell nuclear antigen expression were used as surrogates for spermatogenic function. ...M …
33 results