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Quoted phrase not found in phrase index: "Spermatogenic failure 23"
Page 1
Microdeletions and microduplications linked to severe congenital disorders in infertile men.
Kikas T, Punab AM, Kasak L, Poolamets O, Vihljajev V, Pomm K, Reiman M, Tjagur S, Korrovits P, Punab M, Laan M. Kikas T, et al. Sci Rep. 2023 Jan 11;13(1):574. doi: 10.1038/s41598-023-27750-w. Sci Rep. 2023. PMID: 36631630 Free PMC article.
Data on the clinical validity of DNA copy number variants (CNVs) in spermatogenic failure (SPGF) is limited. This study analyzed the genome-wide CNV profile in 215 men with idiopathic SPGF and 62 normozoospermic fertile men, recruited at the Andrology Clinic, Tartu …
Data on the clinical validity of DNA copy number variants (CNVs) in spermatogenic failure (SPGF) is limited. This study analyz …
Testicular steroid sulfatase overexpression is associated with Leydig cell dysfunction in primary spermatogenic failure.
Lardone MC, Reyes IN, Ortiz E, Piottante A, Palma C, Ebensperger M, Castro A. Lardone MC, et al. Andrology. 2021 Mar;9(2):657-664. doi: 10.1111/andr.12950. Epub 2020 Dec 30. Andrology. 2021. PMID: 33290605 Free article.
BACKGROUND: Decreased testosterone (T) to LH ratio and increased 17beta-estradiol (E2) serum concentrations represent a common finding among patients with severe spermatogenic failure, suggesting a concurrent Leydig cell steroidogenic dysfunction. ...CONCLUSIONS: Ou …
BACKGROUND: Decreased testosterone (T) to LH ratio and increased 17beta-estradiol (E2) serum concentrations represent a common finding among …
Greater prevalence of Y chromosome Q1a3a haplogroup in Y-microdeleted Chilean men: a case-control study.
Lardone MC, Marengo A, Parada-Bustamante A, Cifuentes L, Piottante A, Ebensperger M, Valdevenito R, Castro A. Lardone MC, et al. J Assist Reprod Genet. 2013 Apr;30(4):531-8. doi: 10.1007/s10815-013-9950-z. Epub 2013 Feb 8. J Assist Reprod Genet. 2013. PMID: 23388839 Free PMC article.
PURPOSE: To determine the prevalence of South Amerindian Y chromosome in Chilean patients with spermatogenic failure and their association with classical and/or AZFc-partial Y chromosome deletions. ...No significant differences in the prevalence of AZFc-partial dele …
PURPOSE: To determine the prevalence of South Amerindian Y chromosome in Chilean patients with spermatogenic failure and their …
Androgen receptor gene CAG and GGN repeat polymorphisms in Chilean men with primary severe spermatogenic failure.
Castro-Nallar E, Bacallao K, Parada-Bustamante A, Lardone MC, López PV, Madariaga M, Valdevenito R, Piottante A, Ebensperger M, Castro A. Castro-Nallar E, et al. J Androl. 2010 Nov-Dec;31(6):552-9. doi: 10.2164/jandrol.109.008821. Epub 2010 Apr 8. J Androl. 2010. PMID: 20378930
On the other hand, in idiopathic cases and controls the most common GGN allele was 23, followed by 24, but an inverse relation was found among excryptorchidic cases. ...Moreover, the GGN 24 allele could be contributing to deranged androgen receptor function, associated wit …
On the other hand, in idiopathic cases and controls the most common GGN allele was 23, followed by 24, but an inverse relation was fo …
Decrease in semen quality and Leydig cell function in infertile men: a longitudinal study.
Olesen IA, Joensen UN, Petersen JH, Almstrup K, Rajpert-De Meyts E, Carlsen E, McLachlan R, Juul A, Jørgensen N. Olesen IA, et al. Hum Reprod. 2018 Nov 1;33(11):1963-1974. doi: 10.1093/humrep/dey283. Hum Reprod. 2018. PMID: 30247578
WHAT IS KNOWN ALREADY: Male factors account for up to 50% of human infertility. The most common finding is spermatogenic failure (SgF) yet the life course of semen quality and testosterone production in such men has not been described. ...Also, at follow-up, for pra …
WHAT IS KNOWN ALREADY: Male factors account for up to 50% of human infertility. The most common finding is spermatogenic failure …
Overexpression of CYP19A1 aromatase in Leydig cells is associated with steroidogenic dysfunction in subjects with Sertoli cell-only syndrome.
Lardone MC, Argandoña F, Flórez M, Parada-Bustamante A, Ebensperger M, Palma C, Piottante A, Castro A. Lardone MC, et al. Andrology. 2017 Jan;5(1):41-48. doi: 10.1111/andr.12289. Epub 2016 Oct 21. Andrology. 2017. PMID: 27769104 Free article.
Several observational studies have showed a combination of lower testosterone (T) to LH ratio and higher estradiol (E(2) ) to T ratio in secretory infertile men compared to men with normal spermatogenesis, suggesting a steroidogenic dysfunction of Leydig cells (Lc) that ma …
Several observational studies have showed a combination of lower testosterone (T) to LH ratio and higher estradiol (E(2) ) to T ratio …
Varicocele repair improves semen parameters in azoospermic men with spermatogenic failure.
Kim ED, Leibman BB, Grinblat DM, Lipshultz LI. Kim ED, et al. J Urol. 1999 Sep;162(3 Pt 1):737-40. doi: 10.1097/00005392-199909010-00031. J Urol. 1999. PMID: 10458356 Clinical Trial.
PURPOSE: We analyzed the efficacy of varicocele repair in improving semen parameters in azoospermic men with spermatogenic failure. MATERIALS AND METHODS: After routine clinical evaluation with confirmatory pellet analysis testicular biopsy and varicocele repair wer …
PURPOSE: We analyzed the efficacy of varicocele repair in improving semen parameters in azoospermic men with spermatogenic failure …
Assessing the cognitive and behavioral development of 3-year-old children born from fathers with severe male infertility.
Cheung S, Neri QV, Squires J, Rosenwaks Z, Palermo GD. Cheung S, et al. Am J Obstet Gynecol. 2021 May;224(5):508.e1-508.e11. doi: 10.1016/j.ajog.2020.11.030. Epub 2020 Nov 26. Am J Obstet Gynecol. 2021. PMID: 33248137 Free article.
Ages and Stages Questionnaires outcomes were also compared for the offspring conceived via in vitro fertilization and intracytoplasmic sperm injection by gender; however, no significant differences were observed. In addition, 5 separate subanalyses were then conducted excl …
Ages and Stages Questionnaires outcomes were also compared for the offspring conceived via in vitro fertilization and intracytoplasmic sperm …
Pseudoautosomal abnormalities in terminal AZFb+c deletions are associated with isochromosomes Yp and may lead to abnormal growth and neuropsychiatric function.
Castro A, Rodríguez F, Flórez M, López P, Curotto B, Martínez D, Maturana A, Lardone MC, Palma C, Mericq V, Ebensperger M, Cassorla F. Castro A, et al. Hum Reprod. 2017 Feb;32(2):465-475. doi: 10.1093/humrep/dew333. Epub 2017 Jan 5. Hum Reprod. 2017. PMID: 28057878
WHAT IS KNOWN ALREADY: The microdeletions in the long arm of the Y chromosome (Yq) that include the loss of one to three AZF regions, referred to as Yq microdeletions, constitute the most important known etiological factor for primary spermatogenic failure. Recently …
WHAT IS KNOWN ALREADY: The microdeletions in the long arm of the Y chromosome (Yq) that include the loss of one to three AZF regions, referr …
Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance.
Dierich A, Sairam MR, Monaco L, Fimia GM, Gansmuller A, LeMeur M, Sassone-Corsi P. Dierich A, et al. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13612-7. doi: 10.1073/pnas.95.23.13612. Proc Natl Acad Sci U S A. 1998. PMID: 9811848 Free PMC article.
FSH-R-deficient males are fertile but display small testes and partial spermatogenic failure. Thus, although FSH signaling is not essential for initiating spermatogenesis, it appears to be required for adequate viability and motility of the sperms. ...Although the e …
FSH-R-deficient males are fertile but display small testes and partial spermatogenic failure. Thus, although FSH signaling is …
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