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33 results

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Page 1
Mutational landscape of primary spinal cord astrocytoma.
Cheng L, Zhang F, Zhao X, Wang L, Duan W, Guan J, Wang K, Liu Z, Wang X, Wang Z, Wu H, Chen Z, Teng L, Li Y, Xiao F, Fan T, Jian F. Cheng L, et al. J Pathol. 2023 Jul;260(3):317-328. doi: 10.1002/path.6084. Epub 2023 Apr 28. J Pathol. 2023. PMID: 37114614
Moreover, 12q14.1 (13.7%) encompassing the oncogene CDK4 was recurrently amplified and negatively affected patient prognosis. Besides frequently mutated RTK/RAS pathway and PI3K pathway, the cell cycle pathway controlling the phosphorylation of retinoblastoma protein (RB) …
Moreover, 12q14.1 (13.7%) encompassing the oncogene CDK4 was recurrently amplified and negatively affected patient prognosis. Besides …
MRI characteristics and resectability in spinal cord glioma.
Seaman SC, Bathla G, Park BJ, Woodroffe RW, Smith M, Menezes AH, Noeller J, Yamaguchi S, Hitchon PW. Seaman SC, et al. Clin Neurol Neurosurg. 2021 Jan;200:106321. doi: 10.1016/j.clineuro.2020.106321. Epub 2020 Oct 19. Clin Neurol Neurosurg. 2021. PMID: 33268194
Total excision, subtotal excision, and biopsy were undertaken in 2, 13, and 6 patients, respectively. The success of excision was predicted by MRI, with a significant difference in the extent of resection between IME and IMA (X(2) = 14.123, p = 0.001). ...Homogeneity, marg …
Total excision, subtotal excision, and biopsy were undertaken in 2, 13, and 6 patients, respectively. The success of excision was predict …
Genomic profiling and prognostic factors of H3 K27M-mutant spinal cord diffuse glioma.
Chai RC, Yan H, An SY, Pang B, Chen HY, Mu QH, Zhang KN, Zhang YW, Liu YQ, Liu X, Zhao Z, Jiang T, Wang YZ, Jia WQ. Chai RC, et al. Brain Pathol. 2023 Jul;33(4):e13153. doi: 10.1111/bpa.13153. Epub 2023 Feb 7. Brain Pathol. 2023. PMID: 36751054 Free PMC article.
We found that the H3 K27M-mutant spinal cord glioma, with a median age of 35 years old, had a significantly better prognosis than H3 K27M-mutant brain tumors. We noticed a molecular heterogeneity of H3 K27M-mutant spinal cord astrocytoma via targeted sequencing with 34 cas …
We found that the H3 K27M-mutant spinal cord glioma, with a median age of 35 years old, had a significantly better prognosis than H3 …
Spinal cord astrocytomas: progresses in experimental and clinical investigations for developing recovery neurobiology-based novel therapies.
Teng YD, Abd-El-Barr M, Wang L, Hajiali H, Wu L, Zafonte RD. Teng YD, et al. Exp Neurol. 2019 Jan;311:135-147. doi: 10.1016/j.expneurol.2018.09.010. Epub 2018 Sep 21. Exp Neurol. 2019. PMID: 30243796 Review.
The endeavors were aimed to improve diagnosis, therapy design and prognosis assessment, as well as to define more effective oncolytic targets. ...
The endeavors were aimed to improve diagnosis, therapy design and prognosis assessment, as well as to define more effective oncolytic …
MICROSURGICAL MANAGEMENT OF LOW-GRADE SPINAL CORD ASTROCYTOMA IN ADULTS: A PERSONAL CASE SERIES REPORT AND BRIEF LITERATURE REVIEW.
Pojskić M, Rotim K, Splavski B, Arnautović KI. Pojskić M, et al. Acta Clin Croat. 2020 Sep;59(3):505-512. doi: 10.20471/acc.2020.59.03.15. Acta Clin Croat. 2020. PMID: 34177061 Free PMC article. Review.
Astrocytoma is the second most common intramedullary tumor of predominantly low-grade malignancy in adult patients. Adult astrocytomas have better-quality prognosis compared with astrocytomas in children. Although a standardized surgical management protocol for spinal cord …
Astrocytoma is the second most common intramedullary tumor of predominantly low-grade malignancy in adult patients. Adult astrocytomas have …
Multicentric Spinal Cord Glioblastoma.
Cabrera-Aldana EE, De la Garza Ramos R, Pichardo-Bahena R. Cabrera-Aldana EE, et al. World Neurosurg. 2017 Apr;100:707.e11. doi: 10.1016/j.wneu.2017.01.006. Epub 2017 Jan 13. World Neurosurg. 2017. PMID: 28089804
Prognosis and treatment of spinal cord astrocytoma.
Minehan KJ, Brown PD, Scheithauer BW, Krauss WE, Wright MP. Minehan KJ, et al. Int J Radiat Oncol Biol Phys. 2009 Mar 1;73(3):727-33. doi: 10.1016/j.ijrobp.2008.04.060. Epub 2008 Aug 5. Int J Radiat Oncol Biol Phys. 2009. PMID: 18687533
PURPOSE: To identify the prognostic factors for spinal cord astrocytoma and determine the effects of surgery and radiotherapy on outcome. ...On multivariate analysis, pilocytic histologic type, diagnosis after 1984, longer symptom duration, younger age, minimal surgical ex …
PURPOSE: To identify the prognostic factors for spinal cord astrocytoma and determine the effects of surgery and radiotherapy on outc …
Spinal cord astrocytoma: pathological and treatment considerations.
Minehan KJ, Shaw EG, Scheithauer BW, Davis DL, Onofrio BM. Minehan KJ, et al. J Neurosurg. 1995 Oct;83(4):590-5. doi: 10.3171/jns.1995.83.4.0590. J Neurosurg. 1995. PMID: 7674006
Tumor grade by the Kernohan, et al., or St. Anne-Mayo methods was also a significant predictor of survival in patients with diffuse fibrillary astrocytoma. ...In this series, histological type was the most significant predictor of survival in patients with astrocyto …
Tumor grade by the Kernohan, et al., or St. Anne-Mayo methods was also a significant predictor of survival in patients with diffuse f …
Driver Genetic Mutations in Spinal Cord Gliomas Direct the Degree of Functional Impairment in Tumor-Associated Spinal Cord Injury.
Nagashima Y, Nishimura Y, Ohka F, Eguchi K, Aoki K, Ito H, Nishii T, Oyama T, Hara M, Kitano Y, Masaki H, Wakabayashi T, Natsume A. Nagashima Y, et al. Cells. 2021 Sep 24;10(10):2525. doi: 10.3390/cells10102525. Cells. 2021. PMID: 34685506 Free PMC article.
Furthermore, because the spinal cord is an important communication channel between the brain and the rest of the body, increased attention should be paid to its functional prognosis. In this study, we investigated the functional prognosis and driver genetic mutation …
Furthermore, because the spinal cord is an important communication channel between the brain and the rest of the body, increased attention s …
A comprehensive model including preoperative peripheral blood inflammatory markers for prediction of the prognosis of diffuse spinal cord astrocytoma following surgery.
Pang B, Chai RC, Zhang YW, Chang YZ, Liu WH, Jia WQ, Wang YZ. Pang B, et al. Eur Spine J. 2021 Oct;30(10):2857-2866. doi: 10.1007/s00586-021-06724-4. Epub 2021 Jan 25. Eur Spine J. 2021. PMID: 33495960

METHODS: We performed univariate and multivariate Cox regression to identify prognosis factors. The Kaplan-Meier curves and ROC curves were employed to compare the prognostic value of selected factors. ...Meanwhile, Ki-67 < 10% and resection extent 90% were indep

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METHODS: We performed univariate and multivariate Cox regression to identify prognosis factors. The Kaplan-Meier curves and ROC curve …
33 results