Small molecule screen identifies pyrimethamine as an inhibitor of NRF2-driven esophageal hyperplasia.
Paiboonrungruang C, Xiong Z, Lamson D, Li Y, Bowman B, Chembo J, Huang C, Li J, Livingston EW, Frank JE, Chen V, Li Y, Weissman B, Yuan H, Williams KP, Ben Major M, Chen X.
Paiboonrungruang C, et al.
Redox Biol. 2023 Nov;67:102901. doi: 10.1016/j.redox.2023.102901. Epub 2023 Sep 22.
Redox Biol. 2023.
PMID: 37776708
Free PMC article.
Expression of an Nrf2(E79Q) allele in mouse esophageal epithelium (Sox2CreER;LSL-Nrf2(E79Q/+)) resulted in an NRF2(high) phenotype, which included squamous hyperplasia, hyperkeratinization, and hyperactive glycolysis. ...
Expression of an Nrf2(E79Q) allele in mouse esophageal epithelium (Sox2CreER;LSL-Nrf2(E79Q/+)) resulted in an NRF2(high) phenotype, which in …