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164 results

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Quoted phrase not found in phrase index: "Surfactant metabolism dysfunction, pulmonary, 5"
Page 1
Pulmonary alveolar proteinosis.
Trapnell BC, Nakata K, Bonella F, Campo I, Griese M, Hamilton J, Wang T, Morgan C, Cottin V, McCarthy C. Trapnell BC, et al. Nat Rev Dis Primers. 2019 Mar 7;5(1):16. doi: 10.1038/s41572-019-0066-3. Nat Rev Dis Primers. 2019. PMID: 30846703 Review.
Pulmonary alveolar proteinosis (PAP) is a syndrome characterized by the accumulation of alveolar surfactant and dysfunction of alveolar macrophages. ...Management aims at improving symptoms and quality of life; whole-lung lavage effectively removes exc …
Pulmonary alveolar proteinosis (PAP) is a syndrome characterized by the accumulation of alveolar surfactant and dysfunction …
Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome.
Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M, Schoenfeld D, Thompson BT; National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Brower RG, et al. N Engl J Med. 2004 Jul 22;351(4):327-36. doi: 10.1056/NEJMoa032193. N Engl J Med. 2004. PMID: 15269312 Free article. Clinical Trial.
BACKGROUND: Most patients requiring mechanical ventilation for acute lung injury and the acute respiratory distress syndrome (ARDS) receive positive end-expiratory pressure (PEEP) of 5 to 12 cm of water. Higher PEEP levels may improve oxygenation and reduce ventilat …
BACKGROUND: Most patients requiring mechanical ventilation for acute lung injury and the acute respiratory distress syndrome (ARDS) r …
Pathogenesis of bronchopulmonary dysplasia.
Hayes D Jr, Feola DJ, Murphy BS, Shook LA, Ballard HO. Hayes D Jr, et al. Respiration. 2010;79(5):425-36. doi: 10.1159/000242497. Epub 2009 Sep 25. Respiration. 2010. PMID: 19786727 Free article. Review.
Bronchopulmonary dysplasia (BPD) refers to a heterogeneous group of lung disorders in infants that is commonly associated with prematurity and surfactant deficiency. ...These factors result in chronic inflammation in the infant lung with recurring cycles of …
Bronchopulmonary dysplasia (BPD) refers to a heterogeneous group of lung disorders in infants that is commonly associated with premat …
Inhaled Molgramostim Therapy in Autoimmune Pulmonary Alveolar Proteinosis.
Trapnell BC, Inoue Y, Bonella F, Morgan C, Jouneau S, Bendstrup E, Campo I, Papiris SA, Yamaguchi E, Cetinkaya E, Ilkovich MM, Kramer MR, Veltkamp M, Kreuter M, Baba T, Ganslandt C, Tarnow I, Waterer G, Jouhikainen T; IMPALA Trial Investigators. Trapnell BC, et al. N Engl J Med. 2020 Oct 22;383(17):1635-1644. doi: 10.1056/NEJMoa1913590. Epub 2020 Sep 7. N Engl J Med. 2020. PMID: 32897035 Free PMC article. Clinical Trial.
BACKGROUND: Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare disease characterized by progressive surfactant accumulation and hypoxemia. It is caused by disruption of granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling, which pulmonary …
BACKGROUND: Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare disease characterized by progressive surfactant accumul …
To ventilate, oscillate, or cannulate?
Shekar K, Davies AR, Mullany DV, Tiruvoipati R, Fraser JF. Shekar K, et al. J Crit Care. 2013 Oct;28(5):655-62. doi: 10.1016/j.jcrc.2013.04.009. Epub 2013 Jul 2. J Crit Care. 2013. PMID: 23827735 Review.
The aims have shifted from optimal gas transfer without concern for iatrogenic risks to adequate gas transfer while minimizing lung injury. This change in focus, along with improved ventilator and multiorgan system management, has resulted in a significant improvement in p …
The aims have shifted from optimal gas transfer without concern for iatrogenic risks to adequate gas transfer while minimizing lung i …
Pathogenesis of emphysema: from the bench to the bedside.
Sharafkhaneh A, Hanania NA, Kim V. Sharafkhaneh A, et al. Proc Am Thorac Soc. 2008 May 1;5(4):475-7. doi: 10.1513/pats.200708-126ET. Proc Am Thorac Soc. 2008. PMID: 18453358 Free PMC article. Review.
Chronic obstructive pulmonary disease (COPD) is characterized physiologically by expiratory flow limitation and pathologically by alveolar destruction and enlargement and small and large airway inflammation and remodeling. ...Recent literature implicates surfactant …
Chronic obstructive pulmonary disease (COPD) is characterized physiologically by expiratory flow limitation and pathologically by alv …
Considerations in the management of hypoxemic respiratory failure and persistent pulmonary hypertension in term and late preterm neonates.
Lakshminrusimha S, Konduri GG, Steinhorn RH. Lakshminrusimha S, et al. J Perinatol. 2016 Jun;36 Suppl 2:S12-9. doi: 10.1038/jp.2016.44. J Perinatol. 2016. PMID: 27225960 Review.
Recent advances in our understanding of neonatal pulmonary circulation and the underlying pathophysiology of hypoxemic respiratory failure (HRF)/persistent pulmonary hypertension of the newborn (PPHN) have resulted in more effective management strategies. ...In addi …
Recent advances in our understanding of neonatal pulmonary circulation and the underlying pathophysiology of hypoxemic respiratory fa …
Anti-inflammatory treatment in dysfunction of pulmonary surfactant in meconium-induced acute lung injury.
Mokra D, Drgova A, Kopincova J, Pullmann R, Calkovska A. Mokra D, et al. Adv Exp Med Biol. 2013;756:189-96. doi: 10.1007/978-94-007-4549-0_24. Adv Exp Med Biol. 2013. PMID: 22836635
Inflammation, oxidation, lung edema, and other factors participate in surfactant dysfunction in meconium aspiration syndrome (MAS). ...Each of the anti-inflammatory agents reduced lung edema and neutrophil influx into the lung and partly …
Inflammation, oxidation, lung edema, and other factors participate in surfactant dysfunction in meconium aspiration syn …
Profound Effect of Pulmonary Surfactant on the Treatment of Preterm Infants with Respiratory Distress Syndrome.
Liu L, Deng Q. Liu L, et al. Contrast Media Mol Imaging. 2022 Oct 3;2022:4166994. doi: 10.1155/2022/4166994. eCollection 2022. Contrast Media Mol Imaging. 2022. PMID: 36262981 Free PMC article. Retracted.
Inherited diseases caused by dysfunction of pulmonary surfactant metabolism or surfactant dysfunction have recently been considered the underlying causes of neonatal and pediatric respiratory diseases. ...To further explore the role of …
Inherited diseases caused by dysfunction of pulmonary surfactant metabolism or surfactant dysfunction …
Restoration of surfactant activity by polymyxin B in lipopolysaccharide-potentiated injury of immature rabbit lungs.
Calkovska A, Haegerstrand-Björkman M, Curstedt T. Calkovska A, et al. Sci Rep. 2021 Jan 8;11(1):22. doi: 10.1038/s41598-020-79679-z. Sci Rep. 2021. PMID: 33420141 Free PMC article.
Animals were ventilated for further 2 h. In vitro, addition of 5% S-LPS to surfactant increased minimum surface tension (gammamin) and addition of 1-3% PxB to surfactant/S-LPS mixture restored gammamin to low values. Animals only given S-LPS had lower …
Animals were ventilated for further 2 h. In vitro, addition of 5% S-LPS to surfactant increased minimum surface tension (gamma …
164 results