Stem cell modeling of mitochondrial parkinsonism reveals key functions of OPA1.
Jonikas M, Madill M, Mathy A, Zekoll T, Zois CE, Wigfield S, Kurzawa-Akanbi M, Browne C, Sims D, Chinnery PF, Cowley SA, Tofaris GK.
Jonikas M, et al.
Ann Neurol. 2018 May;83(5):915-925. doi: 10.1002/ana.25221. Epub 2018 Apr 25.
Ann Neurol. 2018.
PMID: 29604226
Free PMC article.
Severity of OPA1 disease associates primarily with the extent of OPA1-mediated fusion, suggesting that activation of this mechanism or identification of its genetic modifiers may have therapeutic or prognostic value. Ann Neurol 2018;83:915-925....
Severity of OPA1 disease associates primarily with the extent of OPA1-mediated fusion, suggesting that activation of this mechanism or ident …