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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1972 1
1974 1
1975 1
1977 2
1978 3
1979 3
1980 3
1981 5
1982 12
1983 15
1984 13
1985 13
1986 23
1987 23
1988 25
1989 18
1990 18
1991 39
1992 43
1993 37
1994 43
1995 26
1996 35
1997 28
1998 44
1999 55
2000 47
2001 52
2002 50
2003 61
2004 62
2005 50
2006 41
2007 42
2008 43
2009 44
2010 41
2011 40
2012 37
2013 36
2014 36
2015 37
2016 37
2017 34
2018 28
2019 22
2020 15
2021 16
2022 14
2023 9
2024 3

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1,353 results

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Page 1
Mild cognitive impairment.
Gauthier S, Reisberg B, Zaudig M, Petersen RC, Ritchie K, Broich K, Belleville S, Brodaty H, Bennett D, Chertkow H, Cummings JL, de Leon M, Feldman H, Ganguli M, Hampel H, Scheltens P, Tierney MC, Whitehouse P, Winblad B; International Psychogeriatric Association Expert Conference on mild cognitive impairment. Gauthier S, et al. Lancet. 2006 Apr 15;367(9518):1262-70. doi: 10.1016/S0140-6736(06)68542-5. Lancet. 2006. PMID: 16631882 Review.
Mild cognitive impairment can thus be regarded as a risk state for dementia, and its identification could lead to secondary prevention by controlling risk factors such as systolic hypertension. The amnestic subtype of mild cognitive impairment has a high risk of pro …
Mild cognitive impairment can thus be regarded as a risk state for dementia, and its identification could lead to secondary prevention by co …
Treatment strategies for isolated systolic hypertension in elderly patients.
Angeli F, Verdecchia P, Masnaghetti S, Vaudo G, Reboldi G. Angeli F, et al. Expert Opin Pharmacother. 2020 Oct;21(14):1713-1723. doi: 10.1080/14656566.2020.1781092. Epub 2020 Jun 25. Expert Opin Pharmacother. 2020. PMID: 32584617
Its prevalence is rising as the result of population aging. Isolated systolic hypertension mostly occurs in older patients accounting for up to 80% of cases. ...Thiazide diuretics and dihydropyridine calcium-channel blockers are the primary compounds used in rand …
Its prevalence is rising as the result of population aging. Isolated systolic hypertension mostly occurs in older patients acc …
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
[No authors listed] [No authors listed] JAMA. 1991 Jun 26;265(24):3255-64. JAMA. 1991. PMID: 2046107 Clinical Trial.
OBJECTIVE: To assess the ability of antihypertensive drug treatment to reduce the risk of nonfatal and fatal (total) stroke in isolated systolic hypertension. DESIGN: Multicenter, randomized, double-blind, placebo-controlled. ...CONCLUSION: In persons aged 60 …
OBJECTIVE: To assess the ability of antihypertensive drug treatment to reduce the risk of nonfatal and fatal (total) stroke in isolated s …
Effects of Sacubitril/Valsartan Versus Olmesartan on Central Hemodynamics in the Elderly With Systolic Hypertension: The PARAMETER Study.
Williams B, Cockcroft JR, Kario K, Zappe DH, Brunel PC, Wang Q, Guo W. Williams B, et al. Hypertension. 2017 Mar;69(3):411-420. doi: 10.1161/HYPERTENSIONAHA.116.08556. Epub 2017 Jan 16. Hypertension. 2017. PMID: 28093466 Clinical Trial.
Effective treatment of systolic hypertension in elderly patients remains a major therapeutic challenge. A multicenter, double-blind, randomized controlled trial with sacubitril/valsartan (LCZ696), a first-in-class angiotensin receptor neprilysin inhibi …
Effective treatment of systolic hypertension in elderly patients remains a major therapeutic challenge. A multicenter, double- …
Effect of Antihypertensive Medication Reduction vs Usual Care on Short-term Blood Pressure Control in Patients With Hypertension Aged 80 Years and Older: The OPTIMISE Randomized Clinical Trial.
Sheppard JP, Burt J, Lown M, Temple E, Lowe R, Fraser R, Allen J, Ford GA, Heneghan C, Hobbs FDR, Jowett S, Kodabuckus S, Little P, Mant J, Mollison J, Payne RA, Williams M, Yu LM, McManus RJ; OPTIMISE Investigators. Sheppard JP, et al. JAMA. 2020 May 26;323(20):2039-2051. doi: 10.1001/jama.2020.4871. JAMA. 2020. PMID: 32453368 Free PMC article. Clinical Trial.
DESIGN, SETTING, AND PARTICIPANTS: The Optimising Treatment for Mild Systolic Hypertension in the Elderly (OPTIMISE) study was a randomized, unblinded, noninferiority trial conducted in 69 primary care sites in England. ...The findings suggest antihype …
DESIGN, SETTING, AND PARTICIPANTS: The Optimising Treatment for Mild Systolic Hypertension in the Elderly (OPTIMISE) study was …
Isolated systolic hypertension of the young and sodium intake.
D'Elia L, Strazzullo P. D'Elia L, et al. Minerva Med. 2022 Oct;113(5):788-797. doi: 10.23736/S0026-4806.21.07740-5. Epub 2021 Sep 29. Minerva Med. 2022. PMID: 34586768
Isolated systolic hypertension is associated with higher risk of cardiovascular disease and all-cause mortality. ...This short review focused on the epidemiological and clinical evidence, the mechanistic pathways and the cluster of pathophysiological factors …
Isolated systolic hypertension is associated with higher risk of cardiovascular disease and all-cause mortality. ...This short …
Isolated Systolic Hypertension: An Update After SPRINT.
Bavishi C, Goel S, Messerli FH. Bavishi C, et al. Am J Med. 2016 Dec;129(12):1251-1258. doi: 10.1016/j.amjmed.2016.08.032. Epub 2016 Sep 14. Am J Med. 2016. PMID: 27639873 Review.
Isolated systolic hypertension is the most common hemodynamic form of hypertension in the elderly. ...Isolated systolic hypertension is associated with substantial mortality and morbidity, particularly of cerebrovascular disease. ...
Isolated systolic hypertension is the most common hemodynamic form of hypertension in the elderly. ...Isolated systolic …
Vitamin D and cardiovascular diseases: Causality.
Wimalawansa SJ. Wimalawansa SJ. J Steroid Biochem Mol Biol. 2018 Jan;175:29-43. doi: 10.1016/j.jsbmb.2016.12.016. Epub 2016 Dec 24. J Steroid Biochem Mol Biol. 2018. PMID: 28027913 Review.
This review analyzed current knowledge regarding the effects of vitamin D on the cardiovascular system. 1,25(OH)(2)D and related epigenetic modifications subdue cellular inflammation, improve overall endothelial functions, reduce age-related systolic hypertension an …
This review analyzed current knowledge regarding the effects of vitamin D on the cardiovascular system. 1,25(OH)(2)D and related epigenetic …
Treatment of isolated systolic hypertension in the elderly.
Duprez D. Duprez D. Expert Rev Cardiovasc Ther. 2012 Nov;10(11):1367-73. doi: 10.1586/erc.12.117. Expert Rev Cardiovasc Ther. 2012. PMID: 23244357 Review.
Systolic hypertension is a major health economy problem within our aging society. ...Treatment of systolic hypertension in the elderly should be based on nonpharmacological measures and medical therapy if the systolic hypertension cannot …
Systolic hypertension is a major health economy problem within our aging society. ...Treatment of systolic hypertens …
Beta-blockers and heart failure.
Cruickshank JM. Cruickshank JM. Indian Heart J. 2010 Mar-Apr;62(2):101-10. Indian Heart J. 2010. PMID: 21180298 Review.
Beta-blockade is effective in the prevention of HF i) in the post-MI period and ii) as first-line agents in the treatment of young/middle-aged hypertension and as second-line agents (to first-line diuretics) in the treatment of elderly systolic hypertension. BB are …
Beta-blockade is effective in the prevention of HF i) in the post-MI period and ii) as first-line agents in the treatment of young/middle-ag …
1,353 results