Treatment of aggressive T-cell lymphoma/leukemia with anti-CD4 CAR T cells.
Feng J, Xu H, Cinquina A, Wu Z, Zhang W, Sun L, Chen Q, Tian L, Song L, Pinz KG, Wada M, Jiang X, Hanes WM, Ma Y, Zhang H.
Feng J, et al.
Front Immunol. 2022 Sep 12;13:997482. doi: 10.3389/fimmu.2022.997482. eCollection 2022.
Front Immunol. 2022.
PMID: 36172388
Free PMC article.
Additionally, CD4-IL15/IL15sushi CAR out-performed CD4 CAR in in vivo models, demonstrating a benefit to IL-15/IL-15sushi inclusion. In a Phase I clinical trial, CD4-IL15/IL15sushi CAR T cells were tested for safety in three patients with different T-cell lymphomas. …
Additionally, CD4-IL15/IL15sushi CAR out-performed CD4 CAR in in vivo models, demonstrating a benefit to IL-15/IL-15sushi inclusion. In a Ph …