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Sarcomatoid renal cell tumor harboring a novel BYSL::TFEB fusion with concurrent TFEB amplification.
Lin R, Flerova E, Wamsley CE, McCue PA, Lallas CD, Jiang W, Huang J, Wang ZX, Li L. Lin R, et al. Genes Chromosomes Cancer. 2023 Jun;62(6):353-360. doi: 10.1002/gcc.23125. Epub 2023 Feb 3. Genes Chromosomes Cancer. 2023. PMID: 36704911
Rare TFEB-amplified RCCs have been described recently and are associated with a more aggressive clinical course. Herein, we report a case of an 86-year-old man with a solid 9.2-cm kidney tumor that showed a diffuse high-grade sarcomatoid morphology. ...
Rare TFEB-amplified RCCs have been described recently and are associated with a more aggressive clinical course. Herein, we report a …
TFEB rearranged renal cell carcinoma. A clinicopathologic and molecular study of 13 cases. Tumors harboring MALAT1-TFEB, ACTB-TFEB, and the novel NEAT1-TFEB translocations constantly express PDL1.
Caliò A, Harada S, Brunelli M, Pedron S, Segala D, Portillo SC, Magi-Galluzzi C, Netto GJ, Mackinnon AC, Martignoni G. Caliò A, et al. Mod Pathol. 2021 Apr;34(4):842-850. doi: 10.1038/s41379-020-00713-6. Epub 2020 Nov 18. Mod Pathol. 2021. PMID: 33208882 Free article.
Although most of TFEB rearranged renal cell carcinomas have an indolent behavior, in the rare cases of advanced metastatic disease targeted therapy and predictive markers remain lacking. In the present study, we collected 13 TFEB rearranged renal cell carcinomas, confirmed …
Although most of TFEB rearranged renal cell carcinomas have an indolent behavior, in the rare cases of advanced metastatic disease targeted …