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2014 4
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Quoted phrase not found in phrase index: "TP63 Gene Rearrangement"
Page 1
ALCL by any other name: the many facets of anaplastic large cell lymphoma.
Irshaid L, Xu ML. Irshaid L, et al. Pathology. 2020 Jan;52(1):100-110. doi: 10.1016/j.pathol.2019.09.007. Epub 2019 Nov 6. Pathology. 2020. PMID: 31706671 Review.
ALK(+) ALCL demonstrates a spectrum of cell cytology ranging from small to large lymphoma cells and characteristic 'hallmark' cells. ALK(+) ALCL consistently demonstrates ALK gene rearrangements and carries a favourable prognosis. ALK(-) ALCL morphologically and imm …
ALK(+) ALCL demonstrates a spectrum of cell cytology ranging from small to large lymphoma cells and characteristic 'hallmark' cells. ALK(+) …
Prognostic factors for primary cutaneous anaplastic large-cell lymphoma: a multicentre retrospective study from Japan.
Miyagaki T, Inoue N, Kamijo H, Boki H, Takahashi-Shishido N, Suga H, Shimauchi T, Kiyohara E, Hirai Y, Yonekura K, Takeuchi K, Sugaya M. Miyagaki T, et al. Br J Dermatol. 2023 Oct 25;189(5):612-620. doi: 10.1093/bjd/ljad266. Br J Dermatol. 2023. PMID: 37539944
We investigated the association between staining pattern and these gene rearrangements. We also assessed the prognostic implications of clinical status, immunohistochemical results and the presence of gene rearrangements. ...TP63 rearrangement w …
We investigated the association between staining pattern and these gene rearrangements. We also assessed the prognostic implic …
Immunohistochemical Approach to Genetic Subtyping of Anaplastic Large Cell Lymphoma.
Feldman AL, Oishi N, Ketterling RP, Ansell SM, Shi M, Dasari S. Feldman AL, et al. Am J Surg Pathol. 2022 Nov 1;46(11):1490-1499. doi: 10.1097/PAS.0000000000001941. Epub 2022 Aug 8. Am J Surg Pathol. 2022. PMID: 35941721 Free PMC article.
Anaplastic large cell lymphoma (ALCL) can be classified genetically based on rearrangements (R) of the ALK , TP63 , and/or DUSP22 genes. ALK- R defines a specific entity, ALK-positive ALCL, while DUSP22- R and TP63- R define subgroups of ALK-negative ALCLs with dist …
Anaplastic large cell lymphoma (ALCL) can be classified genetically based on rearrangements (R) of the ALK , TP63 , and/or DUSP22 gen …
Expression of p63 protein in anaplastic large cell lymphoma: implications for genetic subtyping.
Wang X, Boddicker RL, Dasari S, Sidhu JS, Kadin ME, Macon WR, Ansell SM, Ketterling RP, Rech KL, Feldman AL. Wang X, et al. Hum Pathol. 2017 Jun;64:19-27. doi: 10.1016/j.humpath.2017.01.003. Epub 2017 Jan 30. Hum Pathol. 2017. PMID: 28153507 Free PMC article.
Primary cutaneous and anaplastic lymphoma kinase-negative ALCLs were positive more frequently than anaplastic lymphoma kinase-positive ALCLs (P=.0034). As previously reported, cases with TP63 gene rearrangements expressed p63 uniformly. p63 expression in nonrearrang …
Primary cutaneous and anaplastic lymphoma kinase-negative ALCLs were positive more frequently than anaplastic lymphoma kinase-positive ALCLs …
ALK-Negative Anaplastic Large Cell Lymphoma (ALCL): Prognostic Implications of Molecular Subtyping and JAK-STAT Pathway.
Parkhi M, Bal A, Das A, Kashyap D, Bhardwaj S, Prakash G, Malhotra P. Parkhi M, et al. Appl Immunohistochem Mol Morphol. 2021 Oct 1;29(9):648-656. doi: 10.1097/PAI.0000000000000936. Appl Immunohistochem Mol Morphol. 2021. PMID: 33901030
The subtyping of the ALK-negative ALCL in relation to DUSP22 rearrangement and TP63 expression was done using fluorescence in situ hybridization and immunohistochemistry, respectively. ...ALK-negative ALCL is a genetically heterogeneous disease with widely disparate …
The subtyping of the ALK-negative ALCL in relation to DUSP22 rearrangement and TP63 expression was done using fluorescence in …
Histopathologic, immunophenotypic and cytogenetic features of pulmonary mucoepidermoid carcinoma.
Roden AC, García JJ, Wehrs RN, Colby TV, Khoor A, Leslie KO, Chen L. Roden AC, et al. Mod Pathol. 2014 Nov;27(11):1479-88. doi: 10.1038/modpathol.2014.72. Epub 2014 Apr 18. Mod Pathol. 2014. PMID: 24743219 Free article.
Four cases were excluded because of a split opinion between pathology report and re-review. These cases were negative for MAML2 rearrangement by FISH. TTF-1, napsin A, p40 and p63 immunostains were scored: 0 (negative), 1 (1-25% tumor cells), 2 (26-50%), 3 (51-75%) or 4 (& …
Four cases were excluded because of a split opinion between pathology report and re-review. These cases were negative for MAML2 rearrange …
ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes.
Parrilla Castellar ER, Jaffe ES, Said JW, Swerdlow SH, Ketterling RP, Knudson RA, Sidhu JS, Hsi ED, Karikehalli S, Jiang L, Vasmatzis G, Gibson SE, Ondrejka S, Nicolae A, Grogg KL, Allmer C, Ristow KM, Wilson WH, Macon WR, Law ME, Cerhan JR, Habermann TM, Ansell SM, Dogan A, Maurer MJ, Feldman AL. Parrilla Castellar ER, et al. Blood. 2014 Aug 28;124(9):1473-80. doi: 10.1182/blood-2014-04-571091. Epub 2014 Jun 3. Blood. 2014. PMID: 24894770 Free PMC article.
Hazard ratios for death in these 4 groups after adjusting for International Prognostic Index and age were 1.0 (reference group), 0.58, 8.63, and 4.16, respectively (P = 7.10 10(-5)). ...Thus, ALK-negative ALCL is a genetically heterogeneous disease with widely disparate ou …
Hazard ratios for death in these 4 groups after adjusting for International Prognostic Index and age were 1.0 (reference group), 0.58 …
FOXP1 and TP63 involvement in the progression of myelodysplastic syndrome with 5q- and additional cytogenetic abnormalities.
L'Abbate A, Lo Cunsolo C, Macrì E, Iuzzolino P, Mecucci C, Doglioni C, Coco M, Muscarella LA, Salati S, Tagliafico E, Minoia C, De Tullio G, Guarini A, Testoni N, Agostinelli C, Storlazzi CT. L'Abbate A, et al. BMC Cancer. 2014 Jun 3;14:396. doi: 10.1186/1471-2407-14-396. BMC Cancer. 2014. PMID: 24893616 Free PMC article.
Our results revealed that the FOXP1 and TP63 genes were both relocated along chromosome 3. Strikingly, immunohistochemistry analysis showed altered protein levels, disclosing that this rearrangement triggered the expression of FOXP1 and TP63 genes. FOXP1 was …
Our results revealed that the FOXP1 and TP63 genes were both relocated along chromosome 3. Strikingly, immunohistochemistry analysis …
Genetic Subtypes of Systemic Anaplastic Large Cell Lymphoma Show Distinct Differences in PD-L1 Expression and Regulatory and Cytotoxic T Cells in the Tumor Microenvironment.
Ferreira CR, Manohar V, Zhao S, Bangs CD, Cherry A, Azevedo RS, Lage LAPC, Pereira J, Zerbini MCN, Gratzinger D, Natkunam Y. Ferreira CR, et al. Appl Immunohistochem Mol Morphol. 2020 Jan;28(1):10-16. doi: 10.1097/PAI.0000000000000798. Appl Immunohistochem Mol Morphol. 2020. PMID: 31809310
The subgroups included anaplastic lymphoma kinase (ALK)-positive (ALK+) ALCL and ALK-negative (ALK-) ALCL and DUSP22-rearranged and nonrearranged ALK- ALCL. None of our cases represented the TP63-rearrangement ALK- ALCL subgroup. Our results showed that ALK+ ALCL ha …
The subgroups included anaplastic lymphoma kinase (ALK)-positive (ALK+) ALCL and ALK-negative (ALK-) ALCL and DUSP22-rearranged and nonrearr …
Primary cutaneous anaplastic large-cell lymphoma with DUSP22-IRF4 rearrangement following insect bites.
Zhang Y, Chen M, Yu Y, Liu X, Liu W, Jiang L, Zhang W. Zhang Y, et al. J Cutan Pathol. 2022 Feb;49(2):187-190. doi: 10.1111/cup.14147. Epub 2021 Oct 20. J Cutan Pathol. 2022. PMID: 34622970 Free PMC article.
These cells were immunohistochemically positive for CD45, CD30, and TIA-1 and negative for CD2, CD3, CD4, CD5, CD20, CD7, CD8, and ALK-1. DUSP22-IRF4 rearrangement was detected; on the other hand, TP63 rearrangement was not observed by fluorescence in situ hy …
These cells were immunohistochemically positive for CD45, CD30, and TIA-1 and negative for CD2, CD3, CD4, CD5, CD20, CD7, CD8, and ALK-1. DU …
14 results