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Characteristics and Outcomes of Patients With Multiple Myeloma Who Developed Therapy-Related Acute Myeloid Leukemia and Myelodysplastic Syndrome After Autologous Cell Transplantation.
Yalniz FF, Greenbaum U, Pasvolsky O, Milton DR, Kanagal-Shamanna R, Ramdial J, Srour S, Mehta R, Alousi A, Popat UR, Nieto Y, Kebriaei P, Al-Atrash G, Oran B, Hosing C, Ahmed S, Champlin RE, Shpall EJ, Qazilbash MH, Bashir Q. Yalniz FF, et al. Transplant Cell Ther. 2024 Feb;30(2):205.e1-205.e12. doi: 10.1016/j.jtct.2023.06.015. Epub 2023 Jul 10. Transplant Cell Ther. 2024. PMID: 37437764
In a multivariable model, male gender, advanced age at MM diagnosis, experiencing complete remission after Auto-HCT, and lenalidomide maintenance were independent predictors of developing t-MDS/AML. Among the patients who developed t-MDS/AML, 14 (25%) underwent allogeneic …
In a multivariable model, male gender, advanced age at MM diagnosis, experiencing complete remission after Auto-HCT, and lenalidomide mainte …
High p53 protein expression in therapy-related myeloid neoplasms is associated with adverse karyotype and poor outcome.
Cleven AH, Nardi V, Ok CY, Goswami M, Dal Cin P, Zheng Z, Iafrate AJ, Abdul Hamid MA, Wang SA, Hasserjian RP. Cleven AH, et al. Mod Pathol. 2015 Apr;28(4):552-63. doi: 10.1038/modpathol.2014.153. Epub 2014 Nov 21. Mod Pathol. 2015. PMID: 25412846 Free article.
Mutations in the tumor suppressor gene TP53 are more frequent in therapy-related acute myeloid leukemia and myelodysplastic syndrome than in de novo disease, but the role of p53 immunohistochemistry in the therapy-related se …
Mutations in the tumor suppressor gene TP53 are more frequent in therapy-related acute myeloid leukemia …
Therapy-related leukemia and myelodysplasia following oral administration of etoposide for recurrent breast cancer.
Yagita M, Ieki Y, Onishi R, Huang CL, Adachi M, Horiike S, Konaka Y, Taki T, Miyake M. Yagita M, et al. Int J Oncol. 1998 Jul;13(1):91-6. doi: 10.3892/ijo.13.1.91. Int J Oncol. 1998. PMID: 9625808
We report a high risk of therapy-related acute myeloid leukemia and myelodysplastic syndrome (t-AML/MDS) in patients receiving oral administration of etoposide for recurrent breast cancer. ...Three cases of t-AML/MDS develop …
We report a high risk of therapy-related acute myeloid leukemia and myelodysplastic synd …